Methods of miRNA delivery and possibilities of their application in neuro-oncology
In the current phase of medical progress, practical neuro-oncology faces critical challenges. These include the quest for and development of innovative methodological approaches, as well as the enhancement of conventional therapies to boost their efficacy in treating brain tumors, especially the mal...
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| 格式: | 文件 |
| 语言: | English |
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KeAi Communications Co., Ltd.
2023-12-01
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| 丛编: | Non-coding RNA Research |
| 主题: | |
| 在线阅读: | http://www.sciencedirect.com/science/article/pii/S246805402300063X |
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| author | Ilgiz Gareev Ozal Beylerli Rasim Tamrazov Tatiana Ilyasova Alina Shumadalova Weijie Du Baofeng Yang |
| author_facet | Ilgiz Gareev Ozal Beylerli Rasim Tamrazov Tatiana Ilyasova Alina Shumadalova Weijie Du Baofeng Yang |
| author_sort | Ilgiz Gareev |
| collection | DOAJ |
| description | In the current phase of medical progress, practical neuro-oncology faces critical challenges. These include the quest for and development of innovative methodological approaches, as well as the enhancement of conventional therapies to boost their efficacy in treating brain tumors, especially the malignant varieties. Recent strides in molecular and cellular biology, molecular genetics, and immunology have charted the primary research pathways in the development of new anti-cancer medications, with a particular focus on microRNA (miRNA)-based therapy. MiRNAs possess the ability to function as suppressors of tumor growth while also having the potential to act as oncogenes. MiRNAs wield control over numerous processes within the human body, encompassing tumor growth, proliferation, invasion, metastasis, apoptosis, angiogenesis, and immune responses. A significant impediment to enhancing the efficacy of brain tumor treatment lies in the unresolved challenge of traversing the blood-brain barrier (BBB) and blood-tumor barrier (BTB) to deliver therapeutic agents directly to the tumor tissue. Presently, there is a worldwide effort to conduct intricate research and design endeavors aimed at creating miRNA-based dosage forms and delivery systems that can effectively target various structures within the central nervous system (CNS). MiRNA-based therapy stands out as one of the most promising domains in neuro-oncology. Hence, the development of efficient and safe methods for delivering miRNA agents to the specific target cells within brain tumors is of paramount importance. In this study, we will delve into recent findings regarding various methods for delivering miRNA agents to brain tumor cells. We will explore the advantages and disadvantages of different delivery systems and consider some clinical aspects of miRNA-based therapy for brain tumors. |
| first_indexed | 2024-03-09T02:13:51Z |
| format | Article |
| id | doaj.art-89c3a264ec924afb8696920e1e4490b2 |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2025-03-22T03:58:49Z |
| publishDate | 2023-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-89c3a264ec924afb8696920e1e4490b22024-04-28T10:42:58ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402023-12-0184661674Methods of miRNA delivery and possibilities of their application in neuro-oncologyIlgiz Gareev0Ozal Beylerli1Rasim Tamrazov2Tatiana Ilyasova3Alina Shumadalova4Weijie Du5Baofeng Yang6Department of Pharmacology (The State-Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, 150067, Harbin Medical University, Harbin, China; Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, 150081, PR ChinaCentral Research Laboratory, Bashkir State Medical University, Ufa, Republic of Bashkortostan, 3 Lenin street, 450008, RussiaDepartment of Oncology, Radiology and Radiotherapy, Tyumen State Medical University, 54 Odesskaya Street, 625023, Tyumen, RussiaDepartment of Internal Diseases, Bashkir State Medical University, Ufa, Republic of Bashkortostan, 3 Lenin street, 450008, RussiaDepartment of General Chemistry, Bashkir State Medical University, Ufa, Republic of Bashkortostan, 3 Lenin street, 450008, RussiaDepartment of Pharmacology (The State-Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, 150067, Harbin Medical University, Harbin, China; Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, 150081, PR China; Corresponding author. Department of Pharmacology (The State-Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, 150067，Harbin Medical University, Harbin, China.Department of Pharmacology (The State-Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, 150067, Harbin Medical University, Harbin, China; Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, 150081, PR China; Corresponding author. Department of Pharmacology (The State-Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, 150067，Harbin Medical University, Harbin, China.In the current phase of medical progress, practical neuro-oncology faces critical challenges. These include the quest for and development of innovative methodological approaches, as well as the enhancement of conventional therapies to boost their efficacy in treating brain tumors, especially the malignant varieties. Recent strides in molecular and cellular biology, molecular genetics, and immunology have charted the primary research pathways in the development of new anti-cancer medications, with a particular focus on microRNA (miRNA)-based therapy. MiRNAs possess the ability to function as suppressors of tumor growth while also having the potential to act as oncogenes. MiRNAs wield control over numerous processes within the human body, encompassing tumor growth, proliferation, invasion, metastasis, apoptosis, angiogenesis, and immune responses. A significant impediment to enhancing the efficacy of brain tumor treatment lies in the unresolved challenge of traversing the blood-brain barrier (BBB) and blood-tumor barrier (BTB) to deliver therapeutic agents directly to the tumor tissue. Presently, there is a worldwide effort to conduct intricate research and design endeavors aimed at creating miRNA-based dosage forms and delivery systems that can effectively target various structures within the central nervous system (CNS). MiRNA-based therapy stands out as one of the most promising domains in neuro-oncology. Hence, the development of efficient and safe methods for delivering miRNA agents to the specific target cells within brain tumors is of paramount importance. In this study, we will delve into recent findings regarding various methods for delivering miRNA agents to brain tumor cells. We will explore the advantages and disadvantages of different delivery systems and consider some clinical aspects of miRNA-based therapy for brain tumors.http://www.sciencedirect.com/science/article/pii/S246805402300063XmiRNABrain tumorsDelivery systemTherapyVectorsBlood-brain barrier |
| spellingShingle | Ilgiz Gareev Ozal Beylerli Rasim Tamrazov Tatiana Ilyasova Alina Shumadalova Weijie Du Baofeng Yang Methods of miRNA delivery and possibilities of their application in neuro-oncology Non-coding RNA Research miRNA Brain tumors Delivery system Therapy Vectors Blood-brain barrier |
| title | Methods of miRNA delivery and possibilities of their application in neuro-oncology |
| title_full | Methods of miRNA delivery and possibilities of their application in neuro-oncology |
| title_fullStr | Methods of miRNA delivery and possibilities of their application in neuro-oncology |
| title_full_unstemmed | Methods of miRNA delivery and possibilities of their application in neuro-oncology |
| title_short | Methods of miRNA delivery and possibilities of their application in neuro-oncology |
| title_sort | methods of mirna delivery and possibilities of their application in neuro oncology |
| topic | miRNA Brain tumors Delivery system Therapy Vectors Blood-brain barrier |
| url | http://www.sciencedirect.com/science/article/pii/S246805402300063X |
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