Antiretroviral Therapy Outcomes in Patients with Severe Mental Illness
A retrospective cohort analysis was performed to describe outcomes and retention in care on antiretroviral therapy (ART) of 53 patients with severe mental illness (SMI). Diagnoses were psychosis secondary to HIV (24 patients), psychosis not otherwise specified (12), mania with or without psychosis (...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-09-01
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| Series: | Journal of the International Association of Providers of AIDS Care |
| Online Access: | https://doi.org/10.1177/2325957415593634 |
| _version_ | 1829486771092586496 |
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| author | Alan S. Karstaedt MBBCh Sadhna Kooverjee MBBCh Lucille Singh MBBCh Yasmien Jeenah MBChB Gregory Jonsson MBChB |
| author_facet | Alan S. Karstaedt MBBCh Sadhna Kooverjee MBBCh Lucille Singh MBBCh Yasmien Jeenah MBChB Gregory Jonsson MBChB |
| author_sort | Alan S. Karstaedt MBBCh |
| collection | DOAJ |
| description | A retrospective cohort analysis was performed to describe outcomes and retention in care on antiretroviral therapy (ART) of 53 patients with severe mental illness (SMI). Diagnoses were psychosis secondary to HIV (24 patients), psychosis not otherwise specified (12), mania with or without psychosis (9), depression with psychotic features (4), and schizophrenia and bipolar mood disorder (2 each). The median baseline CD4 count was 66/mm 3 and viral load was 5.4 log 10 copies/mL. Thirteen (25%) patients were lost to follow-up (10 within 6 months), 3 were transferred out, and 3 died. By week 96, 29 (85%) of 34 (64%) patients still in care had a viral load <400 copies/mL and 26 (76%) a viral load <25 copies/mL. Median CD4 count increased to 307/mm 3 . Twenty-seven of 34 patients discontinued antipsychotic medication. Patients with SMI and advanced HIV infection responded well to ART. The first 6 months was important for retention in care. |
| first_indexed | 2024-12-14T23:14:00Z |
| format | Article |
| id | doaj.art-89c3b2be29f749e4b0cce68cc88f4ee5 |
| institution | Directory Open Access Journal |
| issn | 2325-9574 2325-9582 |
| language | English |
| last_indexed | 2024-12-14T23:14:00Z |
| publishDate | 2015-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of the International Association of Providers of AIDS Care |
| spelling | doaj.art-89c3b2be29f749e4b0cce68cc88f4ee52022-12-21T22:44:08ZengSAGE PublishingJournal of the International Association of Providers of AIDS Care2325-95742325-95822015-09-011410.1177/2325957415593634Antiretroviral Therapy Outcomes in Patients with Severe Mental IllnessAlan S. Karstaedt MBBCh0Sadhna Kooverjee MBBCh1Lucille Singh MBBCh2Yasmien Jeenah MBChB3Gregory Jonsson MBChB4Department of Medicine, Division of Infectious Diseases, Chris Hani Baragwanath Hospital and University of the Witwatersrand, Johannesburg, South AfricaDepartment of Medicine, Division of Infectious Diseases, Chris Hani Baragwanath Hospital and University of the Witwatersrand, Johannesburg, South AfricaDepartment of Medicine, Division of Infectious Diseases, Chris Hani Baragwanath Hospital and University of the Witwatersrand, Johannesburg, South AfricaDepartment of Psychiatry, Chris Hani Baragwanath Hospital and University of the Witwatersrand, Johannesburg, South AfricaDepartment of Psychiatry, Chris Hani Baragwanath Hospital and University of the Witwatersrand, Johannesburg, South AfricaA retrospective cohort analysis was performed to describe outcomes and retention in care on antiretroviral therapy (ART) of 53 patients with severe mental illness (SMI). Diagnoses were psychosis secondary to HIV (24 patients), psychosis not otherwise specified (12), mania with or without psychosis (9), depression with psychotic features (4), and schizophrenia and bipolar mood disorder (2 each). The median baseline CD4 count was 66/mm 3 and viral load was 5.4 log 10 copies/mL. Thirteen (25%) patients were lost to follow-up (10 within 6 months), 3 were transferred out, and 3 died. By week 96, 29 (85%) of 34 (64%) patients still in care had a viral load <400 copies/mL and 26 (76%) a viral load <25 copies/mL. Median CD4 count increased to 307/mm 3 . Twenty-seven of 34 patients discontinued antipsychotic medication. Patients with SMI and advanced HIV infection responded well to ART. The first 6 months was important for retention in care.https://doi.org/10.1177/2325957415593634 |
| spellingShingle | Alan S. Karstaedt MBBCh Sadhna Kooverjee MBBCh Lucille Singh MBBCh Yasmien Jeenah MBChB Gregory Jonsson MBChB Antiretroviral Therapy Outcomes in Patients with Severe Mental Illness Journal of the International Association of Providers of AIDS Care |
| title | Antiretroviral Therapy Outcomes in Patients with Severe Mental Illness |
| title_full | Antiretroviral Therapy Outcomes in Patients with Severe Mental Illness |
| title_fullStr | Antiretroviral Therapy Outcomes in Patients with Severe Mental Illness |
| title_full_unstemmed | Antiretroviral Therapy Outcomes in Patients with Severe Mental Illness |
| title_short | Antiretroviral Therapy Outcomes in Patients with Severe Mental Illness |
| title_sort | antiretroviral therapy outcomes in patients with severe mental illness |
| url | https://doi.org/10.1177/2325957415593634 |
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