Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets
Sarcomas are rare tumours with many different subtypes and clinical outcomes; a broader knowledge of their genetic features is required. Here, the authors analyse 2138 soft tissue and bone sarcomas across 45 subtypes using MSK-IMPACT targeted sequencing and find genomic groups that are distinct from...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30453-x |
| _version_ | 1811342903297966080 |
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| author | Benjamin A. Nacev Francisco Sanchez-Vega Shaleigh A. Smith Cristina R. Antonescu Evan Rosenbaum Hongyu Shi Cerise Tang Nicholas D. Socci Satshil Rana Rodrigo Gularte-Mérida Ahmet Zehir Mrinal M. Gounder Timothy G. Bowler Anisha Luthra Bhumika Jadeja Azusa Okada Jonathan A. Strong Jake Stoller Jason E. Chan Ping Chi Sandra P. D’Angelo Mark A. Dickson Ciara M. Kelly Mary Louise Keohan Sujana Movva Katherine Thornton Paul A. Meyers Leonard H. Wexler Emily K. Slotkin Julia L. Glade Bender Neerav N. Shukla Martee L. Hensley John H. Healey Michael P. La Quaglia Kaled M. Alektiar Aimee M. Crago Sam S. Yoon Brian R. Untch Sarah Chiang Narasimhan P. Agaram Meera R. Hameed Michael F. Berger David B. Solit Nikolaus Schultz Marc Ladanyi Samuel Singer William D. Tap |
| author_facet | Benjamin A. Nacev Francisco Sanchez-Vega Shaleigh A. Smith Cristina R. Antonescu Evan Rosenbaum Hongyu Shi Cerise Tang Nicholas D. Socci Satshil Rana Rodrigo Gularte-Mérida Ahmet Zehir Mrinal M. Gounder Timothy G. Bowler Anisha Luthra Bhumika Jadeja Azusa Okada Jonathan A. Strong Jake Stoller Jason E. Chan Ping Chi Sandra P. D’Angelo Mark A. Dickson Ciara M. Kelly Mary Louise Keohan Sujana Movva Katherine Thornton Paul A. Meyers Leonard H. Wexler Emily K. Slotkin Julia L. Glade Bender Neerav N. Shukla Martee L. Hensley John H. Healey Michael P. La Quaglia Kaled M. Alektiar Aimee M. Crago Sam S. Yoon Brian R. Untch Sarah Chiang Narasimhan P. Agaram Meera R. Hameed Michael F. Berger David B. Solit Nikolaus Schultz Marc Ladanyi Samuel Singer William D. Tap |
| author_sort | Benjamin A. Nacev |
| collection | DOAJ |
| description | Sarcomas are rare tumours with many different subtypes and clinical outcomes; a broader knowledge of their genetic features is required. Here, the authors analyse 2138 soft tissue and bone sarcomas across 45 subtypes using MSK-IMPACT targeted sequencing and find genomic groups that are distinct from histological subgroups. |
| first_indexed | 2024-04-13T19:20:17Z |
| format | Article |
| id | doaj.art-89c42dddd0f647ee90d7805699d564f6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T19:20:17Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-89c42dddd0f647ee90d7805699d564f62022-12-22T02:33:34ZengNature PortfolioNature Communications2041-17232022-06-0113111510.1038/s41467-022-30453-xClinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targetsBenjamin A. Nacev0Francisco Sanchez-Vega1Shaleigh A. Smith2Cristina R. Antonescu3Evan Rosenbaum4Hongyu Shi5Cerise Tang6Nicholas D. Socci7Satshil Rana8Rodrigo Gularte-Mérida9Ahmet Zehir10Mrinal M. Gounder11Timothy G. Bowler12Anisha Luthra13Bhumika Jadeja14Azusa Okada15Jonathan A. Strong16Jake Stoller17Jason E. Chan18Ping Chi19Sandra P. D’Angelo20Mark A. Dickson21Ciara M. Kelly22Mary Louise Keohan23Sujana Movva24Katherine Thornton25Paul A. Meyers26Leonard H. Wexler27Emily K. Slotkin28Julia L. Glade Bender29Neerav N. Shukla30Martee L. Hensley31John H. Healey32Michael P. La Quaglia33Kaled M. Alektiar34Aimee M. Crago35Sam S. Yoon36Brian R. Untch37Sarah Chiang38Narasimhan P. Agaram39Meera R. Hameed40Michael F. Berger41David B. Solit42Nikolaus Schultz43Marc Ladanyi44Samuel Singer45William D. Tap46Department of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterSarcomas are rare tumours with many different subtypes and clinical outcomes; a broader knowledge of their genetic features is required. Here, the authors analyse 2138 soft tissue and bone sarcomas across 45 subtypes using MSK-IMPACT targeted sequencing and find genomic groups that are distinct from histological subgroups.https://doi.org/10.1038/s41467-022-30453-x |
| spellingShingle | Benjamin A. Nacev Francisco Sanchez-Vega Shaleigh A. Smith Cristina R. Antonescu Evan Rosenbaum Hongyu Shi Cerise Tang Nicholas D. Socci Satshil Rana Rodrigo Gularte-Mérida Ahmet Zehir Mrinal M. Gounder Timothy G. Bowler Anisha Luthra Bhumika Jadeja Azusa Okada Jonathan A. Strong Jake Stoller Jason E. Chan Ping Chi Sandra P. D’Angelo Mark A. Dickson Ciara M. Kelly Mary Louise Keohan Sujana Movva Katherine Thornton Paul A. Meyers Leonard H. Wexler Emily K. Slotkin Julia L. Glade Bender Neerav N. Shukla Martee L. Hensley John H. Healey Michael P. La Quaglia Kaled M. Alektiar Aimee M. Crago Sam S. Yoon Brian R. Untch Sarah Chiang Narasimhan P. Agaram Meera R. Hameed Michael F. Berger David B. Solit Nikolaus Schultz Marc Ladanyi Samuel Singer William D. Tap Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets Nature Communications |
| title | Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets |
| title_full | Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets |
| title_fullStr | Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets |
| title_full_unstemmed | Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets |
| title_short | Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets |
| title_sort | clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets |
| url | https://doi.org/10.1038/s41467-022-30453-x |
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