Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocycles
Ultrasonic irradiation serves as a vigorous and environmentally sustainable approach for augmenting multicomponent reactions (MCRs), offering benefits such as thermal enhancement, agitation, and activation, among others. Malononitrile emerges as a versatile reagent in this context, participating in...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Ultrasonics Sonochemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1350417723004534 |
| _version_ | 1797347825788387328 |
|---|---|
| author | Ramin Javahershenas Sahand Nikzat |
| author_facet | Ramin Javahershenas Sahand Nikzat |
| author_sort | Ramin Javahershenas |
| collection | DOAJ |
| description | Ultrasonic irradiation serves as a vigorous and environmentally sustainable approach for augmenting multicomponent reactions (MCRs), offering benefits such as thermal enhancement, agitation, and activation, among others. Malononitrile emerges as a versatile reagent in this context, participating in a myriad of MCRs to produce structurally diverse heterocyclic frameworks. This review encapsulates the critical role of malononitrile in the sonochemical multicomponent synthesis of these heterocyclic structures. The paper further delves into the biochemical and pharmacological implications of these heterocycles, elucidating their reaction mechanisms as well as delineating the method's scope and limitations. We furnish an overview of the merits and challenges inherent to this synthetic approach and offer insights for potential avenues in future research. |
| first_indexed | 2024-03-08T11:54:32Z |
| format | Article |
| id | doaj.art-89c481af847a437bb8b63491b5cf3d01 |
| institution | Directory Open Access Journal |
| issn | 1350-4177 |
| language | English |
| last_indexed | 2024-03-08T11:54:32Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ultrasonics Sonochemistry |
| spelling | doaj.art-89c481af847a437bb8b63491b5cf3d012024-01-24T05:18:36ZengElsevierUltrasonics Sonochemistry1350-41772024-01-01102106741Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocyclesRamin Javahershenas0Sahand Nikzat1Department of Organic Chemistry, Faculty of Chemistry, Urmia University, Urmia, Iran; Corresponding author.Chemical Physics Theory Group, Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, CanadaUltrasonic irradiation serves as a vigorous and environmentally sustainable approach for augmenting multicomponent reactions (MCRs), offering benefits such as thermal enhancement, agitation, and activation, among others. Malononitrile emerges as a versatile reagent in this context, participating in a myriad of MCRs to produce structurally diverse heterocyclic frameworks. This review encapsulates the critical role of malononitrile in the sonochemical multicomponent synthesis of these heterocyclic structures. The paper further delves into the biochemical and pharmacological implications of these heterocycles, elucidating their reaction mechanisms as well as delineating the method's scope and limitations. We furnish an overview of the merits and challenges inherent to this synthetic approach and offer insights for potential avenues in future research.http://www.sciencedirect.com/science/article/pii/S1350417723004534MalononitrileUltrasoundSonochemistryHeterocyclesMulticomponent reactionsSynthesis |
| spellingShingle | Ramin Javahershenas Sahand Nikzat Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocycles Ultrasonics Sonochemistry Malononitrile Ultrasound Sonochemistry Heterocycles Multicomponent reactions Synthesis |
| title | Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocycles |
| title_full | Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocycles |
| title_fullStr | Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocycles |
| title_full_unstemmed | Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocycles |
| title_short | Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocycles |
| title_sort | recent developments using malononitrile in ultrasound assisted multicomponent synthesis of heterocycles |
| topic | Malononitrile Ultrasound Sonochemistry Heterocycles Multicomponent reactions Synthesis |
| url | http://www.sciencedirect.com/science/article/pii/S1350417723004534 |
| work_keys_str_mv | AT raminjavahershenas recentdevelopmentsusingmalononitrileinultrasoundassistedmulticomponentsynthesisofheterocycles AT sahandnikzat recentdevelopmentsusingmalononitrileinultrasoundassistedmulticomponentsynthesisofheterocycles |