The Effects of Enteral Nutrition on the Intestinal Environment in Patients in a Persistent Vegetative State
Enteral nutrition (EN) is a rational approach to providing nutritional intake via the intestines in patients who are unable to tolerate parenteral nutrition. We conducted a preliminary study to investigate the effects of EN on the intestinal environment in 10 patients in a persistent vegetative stat...
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MDPI AG
2022-02-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/11/4/549 |
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| author | Hiroshi Matsuoka Takumi Tochio Ayako Watanabe Kohei Funasaka Yoshiki Hirooka Tenagy Hartanto Yuka Togashi Misa Saito Yuichiro Nishimoto Yoshinori Mizuguchi Masanobu Kumon Chieko Sakuragi Kouichi Suda Yuichi Hirose Isao Morita |
| author_facet | Hiroshi Matsuoka Takumi Tochio Ayako Watanabe Kohei Funasaka Yoshiki Hirooka Tenagy Hartanto Yuka Togashi Misa Saito Yuichiro Nishimoto Yoshinori Mizuguchi Masanobu Kumon Chieko Sakuragi Kouichi Suda Yuichi Hirose Isao Morita |
| author_sort | Hiroshi Matsuoka |
| collection | DOAJ |
| description | Enteral nutrition (EN) is a rational approach to providing nutritional intake via the intestines in patients who are unable to tolerate parenteral nutrition. We conducted a preliminary study to investigate the effects of EN on the intestinal environment in 10 patients in a persistent vegetative state (PVS) (<i>n</i> = 5 each in the EN and EN with probiotics; <i>Clostridium butyricum MIYAIRI 588</i>) groups compared with 10 healthy controls. The results of 16S amplicon sequencing of the intestinal microbiota showed that EN led to dysbiosis with a decrease in α-diversity and an obvious change in β-diversity. A particularly significant decrease was seen in useful intestinal bacteria such as <i>Bifidobacterium</i> and butyrate-producing bacteria. Analysis of intestinal metabolites also supported these results, showing significant decreases in butyric and pyruvic acid after EN. Although <i>C. butyricum</i><i>MIYAIRI 588</i> improved some intestinal metabolites that were decreased after EN, it did not improve the dysbiosis of the intestinal microbiota. These findings indicate that EN causes dysbiosis of the intestinal microbiota and an imbalance in some intestinal metabolites in patients in a PVS. Moreover, although <i>C. butyricum</i><i>MIYAIRI 588</i> improved the imbalance of some intestinal metabolites after EN, it did not prevent dysbiosis of the intestinal microbiota. |
| first_indexed | 2024-03-09T21:58:47Z |
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| language | English |
| last_indexed | 2024-03-09T21:58:47Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-89c4985ddbf54127bd36999fb5e24efd2023-11-23T19:53:37ZengMDPI AGFoods2304-81582022-02-0111454910.3390/foods11040549The Effects of Enteral Nutrition on the Intestinal Environment in Patients in a Persistent Vegetative StateHiroshi Matsuoka0Takumi Tochio1Ayako Watanabe2Kohei Funasaka3Yoshiki Hirooka4Tenagy Hartanto5Yuka Togashi6Misa Saito7Yuichiro Nishimoto8Yoshinori Mizuguchi9Masanobu Kumon10Chieko Sakuragi11Kouichi Suda12Yuichi Hirose13Isao Morita14Department of Surgery, Fujita Health University, Toyoake 470-1192, Aichi, JapanDepartment of Gastroenterology and Hepatology, Fujita Health University, Toyoake 470-1192, Aichi, JapanDepartment of Gastroenterology and Hepatology, Fujita Health University, Toyoake 470-1192, Aichi, JapanDepartment of Gastroenterology and Hepatology, Fujita Health University, Toyoake 470-1192, Aichi, JapanDepartment of Gastroenterology and Hepatology, Fujita Health University, Toyoake 470-1192, Aichi, JapanMetabologenomics, Inc., Tsuruoka 997-0052, Yamagata, JapanMetabologenomics, Inc., Tsuruoka 997-0052, Yamagata, JapanMetabologenomics, Inc., Tsuruoka 997-0052, Yamagata, JapanMetabologenomics, Inc., Tsuruoka 997-0052, Yamagata, JapanMetabologenomics, Inc., Tsuruoka 997-0052, Yamagata, JapanDepartment of Neurosurgery, Fujita Health University, Toyoake 470-1192, Aichi, JapanNursing Department, Fujita Health University Hospital, Toyoake 470-1192, Aichi, JapanDepartment of Surgery, Fujita Health University, Toyoake 470-1192, Aichi, JapanDepartment of Neurosurgery, Fujita Health University, Toyoake 470-1192, Aichi, JapanDepartment of Neurosurgery, Fujita Health University, Toyoake 470-1192, Aichi, JapanEnteral nutrition (EN) is a rational approach to providing nutritional intake via the intestines in patients who are unable to tolerate parenteral nutrition. We conducted a preliminary study to investigate the effects of EN on the intestinal environment in 10 patients in a persistent vegetative state (PVS) (<i>n</i> = 5 each in the EN and EN with probiotics; <i>Clostridium butyricum MIYAIRI 588</i>) groups compared with 10 healthy controls. The results of 16S amplicon sequencing of the intestinal microbiota showed that EN led to dysbiosis with a decrease in α-diversity and an obvious change in β-diversity. A particularly significant decrease was seen in useful intestinal bacteria such as <i>Bifidobacterium</i> and butyrate-producing bacteria. Analysis of intestinal metabolites also supported these results, showing significant decreases in butyric and pyruvic acid after EN. Although <i>C. butyricum</i><i>MIYAIRI 588</i> improved some intestinal metabolites that were decreased after EN, it did not improve the dysbiosis of the intestinal microbiota. These findings indicate that EN causes dysbiosis of the intestinal microbiota and an imbalance in some intestinal metabolites in patients in a PVS. Moreover, although <i>C. butyricum</i><i>MIYAIRI 588</i> improved the imbalance of some intestinal metabolites after EN, it did not prevent dysbiosis of the intestinal microbiota.https://www.mdpi.com/2304-8158/11/4/549enteral nutritionintestinal environmentdysbiosisprobiotics |
| spellingShingle | Hiroshi Matsuoka Takumi Tochio Ayako Watanabe Kohei Funasaka Yoshiki Hirooka Tenagy Hartanto Yuka Togashi Misa Saito Yuichiro Nishimoto Yoshinori Mizuguchi Masanobu Kumon Chieko Sakuragi Kouichi Suda Yuichi Hirose Isao Morita The Effects of Enteral Nutrition on the Intestinal Environment in Patients in a Persistent Vegetative State Foods enteral nutrition intestinal environment dysbiosis probiotics |
| title | The Effects of Enteral Nutrition on the Intestinal Environment in Patients in a Persistent Vegetative State |
| title_full | The Effects of Enteral Nutrition on the Intestinal Environment in Patients in a Persistent Vegetative State |
| title_fullStr | The Effects of Enteral Nutrition on the Intestinal Environment in Patients in a Persistent Vegetative State |
| title_full_unstemmed | The Effects of Enteral Nutrition on the Intestinal Environment in Patients in a Persistent Vegetative State |
| title_short | The Effects of Enteral Nutrition on the Intestinal Environment in Patients in a Persistent Vegetative State |
| title_sort | effects of enteral nutrition on the intestinal environment in patients in a persistent vegetative state |
| topic | enteral nutrition intestinal environment dysbiosis probiotics |
| url | https://www.mdpi.com/2304-8158/11/4/549 |
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