Immuno-modulatory activity of Rasayana Churna (An Ayurvedic compound formulation) in wistar albino rats
Background: Rasayana Churna is a poly-herbal formulation comprising fine powders of Guduchi (Tinospora cordifolia Linn.), Gokshura (Tribulus terrestris Linn.) and Amalaki (Emblica officinalis Linn.) in equal quantities. In Ayurveda, it is expected that the therapeutic efficacy of drug will be increa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Indian Journal of Ayurveda and Integrative Medicine KLEU |
| Subjects: | |
| Online Access: | http://www.ijaim.in/article.asp?issn=2772-6010;year=2019;volume=1;issue=1;spage=55;epage=61;aulast=Swapnil |
| _version_ | 1797866644560674816 |
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| author | Chaudhari Swapnil Verma Priyanka R Galib M Nariya B J Patgiri P K Prajapati |
| author_facet | Chaudhari Swapnil Verma Priyanka R Galib M Nariya B J Patgiri P K Prajapati |
| author_sort | Chaudhari Swapnil |
| collection | DOAJ |
| description | Background: Rasayana Churna is a poly-herbal formulation comprising fine powders of Guduchi (Tinospora cordifolia Linn.), Gokshura (Tribulus terrestris Linn.) and Amalaki (Emblica officinalis Linn.) in equal quantities. In Ayurveda, it is expected that the therapeutic efficacy of drug will be increased by levigating with its own juice or decoction. Kupeelu (Strychnos nux-vomica Linn.) is incorporated in this formulation since it is having analgesic, anti-inflammatory and adaptogenic properties. In current work, the immuno-modulatory activity of Rasayana Churna and Bhavita Rasayana Churna each mixed with Kupeelu was evaluated for humoral antibody formation and cell-mediated immunity in suitable experimental models.
Methods: Test drugs were administered orally to the albino rats at a dose of 540mg/kg body weight. Haemagglutination titre, body weight, hematological and histological observations were recorded to assess effects on humoral immunity. Cell-mediated immunity was assessed by immunological paw edema volume.
Results: Both the test drugs have minimal effects on SRBC induced humoral immune response. They did not modify the antibody titre values, hematological values and histo-pathological parameters. Both the drugs produced marked effect on cell mediated immunity response against triple antigen.
Conclusion: Rasayana Churna mixed with Kupeelu have more pronounced effect as compared to Bhavita Rasayana Churna mixed with Kupeelu in suppressing immunological edema. |
| first_indexed | 2024-04-09T23:28:42Z |
| format | Article |
| id | doaj.art-89c5beef6d2741a3a2e18f55f173dfe6 |
| institution | Directory Open Access Journal |
| issn | 2772-6010 2772-6029 |
| language | English |
| last_indexed | 2024-04-09T23:28:42Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ayurveda and Integrative Medicine KLEU |
| spelling | doaj.art-89c5beef6d2741a3a2e18f55f173dfe62023-03-21T07:35:06ZengWolters Kluwer Medknow PublicationsIndian Journal of Ayurveda and Integrative Medicine KLEU2772-60102772-60292019-01-01115561Immuno-modulatory activity of Rasayana Churna (An Ayurvedic compound formulation) in wistar albino ratsChaudhari SwapnilVerma PriyankaR GalibM NariyaB J PatgiriP K PrajapatiBackground: Rasayana Churna is a poly-herbal formulation comprising fine powders of Guduchi (Tinospora cordifolia Linn.), Gokshura (Tribulus terrestris Linn.) and Amalaki (Emblica officinalis Linn.) in equal quantities. In Ayurveda, it is expected that the therapeutic efficacy of drug will be increased by levigating with its own juice or decoction. Kupeelu (Strychnos nux-vomica Linn.) is incorporated in this formulation since it is having analgesic, anti-inflammatory and adaptogenic properties. In current work, the immuno-modulatory activity of Rasayana Churna and Bhavita Rasayana Churna each mixed with Kupeelu was evaluated for humoral antibody formation and cell-mediated immunity in suitable experimental models. Methods: Test drugs were administered orally to the albino rats at a dose of 540mg/kg body weight. Haemagglutination titre, body weight, hematological and histological observations were recorded to assess effects on humoral immunity. Cell-mediated immunity was assessed by immunological paw edema volume. Results: Both the test drugs have minimal effects on SRBC induced humoral immune response. They did not modify the antibody titre values, hematological values and histo-pathological parameters. Both the drugs produced marked effect on cell mediated immunity response against triple antigen. Conclusion: Rasayana Churna mixed with Kupeelu have more pronounced effect as compared to Bhavita Rasayana Churna mixed with Kupeelu in suppressing immunological edema.http://www.ijaim.in/article.asp?issn=2772-6010;year=2019;volume=1;issue=1;spage=55;epage=61;aulast=Swapnilhaemagglutination titreimmune-modulatory activityrasayana churnastrychnos nux-vomica |
| spellingShingle | Chaudhari Swapnil Verma Priyanka R Galib M Nariya B J Patgiri P K Prajapati Immuno-modulatory activity of Rasayana Churna (An Ayurvedic compound formulation) in wistar albino rats Indian Journal of Ayurveda and Integrative Medicine KLEU haemagglutination titre immune-modulatory activity rasayana churna strychnos nux-vomica |
| title | Immuno-modulatory activity of Rasayana Churna (An Ayurvedic compound formulation) in wistar albino rats |
| title_full | Immuno-modulatory activity of Rasayana Churna (An Ayurvedic compound formulation) in wistar albino rats |
| title_fullStr | Immuno-modulatory activity of Rasayana Churna (An Ayurvedic compound formulation) in wistar albino rats |
| title_full_unstemmed | Immuno-modulatory activity of Rasayana Churna (An Ayurvedic compound formulation) in wistar albino rats |
| title_short | Immuno-modulatory activity of Rasayana Churna (An Ayurvedic compound formulation) in wistar albino rats |
| title_sort | immuno modulatory activity of rasayana churna an ayurvedic compound formulation in wistar albino rats |
| topic | haemagglutination titre immune-modulatory activity rasayana churna strychnos nux-vomica |
| url | http://www.ijaim.in/article.asp?issn=2772-6010;year=2019;volume=1;issue=1;spage=55;epage=61;aulast=Swapnil |
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