Comprehensive Landscape of RRM2 with Immune Infiltration in Pan-Cancer
As a crucial subunit of ribonucleotide reductase, RRM2 plays a significant part in DNA synthesis. This study aimed to elucidate the comprehensive landscape of RRM2 in human cancers. With different bioinformatics platforms, we investigated the expression pattern, prognostic significance, mutational l...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/12/2938 |
| _version_ | 1797489135935553536 |
|---|---|
| author | Zijian Zhou Qiang Song Yuanyuan Yang Lujia Wang Zhong Wu |
| author_facet | Zijian Zhou Qiang Song Yuanyuan Yang Lujia Wang Zhong Wu |
| author_sort | Zijian Zhou |
| collection | DOAJ |
| description | As a crucial subunit of ribonucleotide reductase, RRM2 plays a significant part in DNA synthesis. This study aimed to elucidate the comprehensive landscape of RRM2 in human cancers. With different bioinformatics platforms, we investigated the expression pattern, prognostic significance, mutational landscapes, gene interaction network, signaling pathways and immune infiltration of RRM2 in tumors. We found that RRM2 expression was predominantly up-expressed in tumor tissues in most tumors. Concurrently, RRM2 expression was significantly associated with worse prognosis and tumor stage across TCGA cancers. Moreover, RRM2 high levels were critically associated with the infiltration of natural killer T cells and immune scores. RRM2 was positively related to immune checkpoints, tumor mutation burden, microsatellite instability, neoantigen, and cytotoxic T lymphocyte in several cancers, predicting effective response to immunotherapy. Meanwhile, a strong co-expression of RRM2 with immune-related genes was observed. Additionally, multiple Cox regression analysis showed that RRM2 was an independent prognostic factor in bladder cancer (BLCA). Eventually, we verified that RRM2 was overexpressed in BLCA clinical samples and cell lines. Blocking RRM2 could suppress BLCA cells’ growth and proliferation while enhancing sensitivity to cisplatin. This study provided a new perspective for understanding RRM2 in cancers and new strategies for tumor immunotherapy. |
| first_indexed | 2024-03-10T00:13:11Z |
| format | Article |
| id | doaj.art-89c603be4d674f01842b31f1b6cd380c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:13:11Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-89c603be4d674f01842b31f1b6cd380c2023-11-23T15:56:51ZengMDPI AGCancers2072-66942022-06-011412293810.3390/cancers14122938Comprehensive Landscape of RRM2 with Immune Infiltration in Pan-CancerZijian Zhou0Qiang Song1Yuanyuan Yang2Lujia Wang3Zhong Wu4Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Urology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Urology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaAs a crucial subunit of ribonucleotide reductase, RRM2 plays a significant part in DNA synthesis. This study aimed to elucidate the comprehensive landscape of RRM2 in human cancers. With different bioinformatics platforms, we investigated the expression pattern, prognostic significance, mutational landscapes, gene interaction network, signaling pathways and immune infiltration of RRM2 in tumors. We found that RRM2 expression was predominantly up-expressed in tumor tissues in most tumors. Concurrently, RRM2 expression was significantly associated with worse prognosis and tumor stage across TCGA cancers. Moreover, RRM2 high levels were critically associated with the infiltration of natural killer T cells and immune scores. RRM2 was positively related to immune checkpoints, tumor mutation burden, microsatellite instability, neoantigen, and cytotoxic T lymphocyte in several cancers, predicting effective response to immunotherapy. Meanwhile, a strong co-expression of RRM2 with immune-related genes was observed. Additionally, multiple Cox regression analysis showed that RRM2 was an independent prognostic factor in bladder cancer (BLCA). Eventually, we verified that RRM2 was overexpressed in BLCA clinical samples and cell lines. Blocking RRM2 could suppress BLCA cells’ growth and proliferation while enhancing sensitivity to cisplatin. This study provided a new perspective for understanding RRM2 in cancers and new strategies for tumor immunotherapy.https://www.mdpi.com/2072-6694/14/12/2938RRM2pan-cancerprognosisimmune infiltrationimmunotherapybladder cancer |
| spellingShingle | Zijian Zhou Qiang Song Yuanyuan Yang Lujia Wang Zhong Wu Comprehensive Landscape of RRM2 with Immune Infiltration in Pan-Cancer Cancers RRM2 pan-cancer prognosis immune infiltration immunotherapy bladder cancer |
| title | Comprehensive Landscape of RRM2 with Immune Infiltration in Pan-Cancer |
| title_full | Comprehensive Landscape of RRM2 with Immune Infiltration in Pan-Cancer |
| title_fullStr | Comprehensive Landscape of RRM2 with Immune Infiltration in Pan-Cancer |
| title_full_unstemmed | Comprehensive Landscape of RRM2 with Immune Infiltration in Pan-Cancer |
| title_short | Comprehensive Landscape of RRM2 with Immune Infiltration in Pan-Cancer |
| title_sort | comprehensive landscape of rrm2 with immune infiltration in pan cancer |
| topic | RRM2 pan-cancer prognosis immune infiltration immunotherapy bladder cancer |
| url | https://www.mdpi.com/2072-6694/14/12/2938 |
| work_keys_str_mv | AT zijianzhou comprehensivelandscapeofrrm2withimmuneinfiltrationinpancancer AT qiangsong comprehensivelandscapeofrrm2withimmuneinfiltrationinpancancer AT yuanyuanyang comprehensivelandscapeofrrm2withimmuneinfiltrationinpancancer AT lujiawang comprehensivelandscapeofrrm2withimmuneinfiltrationinpancancer AT zhongwu comprehensivelandscapeofrrm2withimmuneinfiltrationinpancancer |