Associations of maternal iron deficiency with malaria infection in a cohort of pregnant Papua New Guinean women
Abstract Background Iron deficiency (ID) is common in malaria-endemic settings. Intermittent preventative treatment of malaria in pregnancy (IPTp) and iron supplementation are core components of antenatal care in endemic regions to prevent adverse pregnancy outcomes. ID has been associated with redu...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Malaria Journal |
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| Online Access: | https://doi.org/10.1186/s12936-022-04177-8 |
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| author | Holger W. Unger Andie Bleicher Maria Ome-Kaius Elizabeth H. Aitken Stephen J. Rogerson |
| author_facet | Holger W. Unger Andie Bleicher Maria Ome-Kaius Elizabeth H. Aitken Stephen J. Rogerson |
| author_sort | Holger W. Unger |
| collection | DOAJ |
| description | Abstract Background Iron deficiency (ID) is common in malaria-endemic settings. Intermittent preventative treatment of malaria in pregnancy (IPTp) and iron supplementation are core components of antenatal care in endemic regions to prevent adverse pregnancy outcomes. ID has been associated with reduced risk of malaria infection, and correspondingly, iron supplementation with increased risk of malaria infection, in some studies. Methods A secondary analysis was conducted amongst 1888 pregnant women enrolled in a malaria prevention trial in Papua New Guinea. Maternal ID was defined as inflammation-corrected plasma ferritin levels < 15 μg/L at antenatal enrolment. Malaria burden (Plasmodium falciparum, Plasmodium vivax) was determined by light microscopy, polymerase chain reaction, and placental histology. Multiple logistic and linear regression analyses explored the relationship of ID or ferritin levels with indicators of malaria infection. Models were fitted with interaction terms to assess for modification of iron-malaria relationships by gravidity or treatment arm. Results Two-thirds (n = 1226) and 13.7% (n = 258) of women had ID and peripheral parasitaemia, respectively, at antenatal enrolment (median gestational age: 22 weeks), and 18.7% (120/1,356) had evidence of malaria infection on placental histology. Overall, ID was associated with reduced odds of peripheral parasitaemia at enrolment (adjusted odds ratio [aOR] 0.50; 95% confidence interval [95% CI] 0.38, 0.66, P < 0.001); peripheral parasitaemia at delivery (aOR 0.68, 95% CI 0.46, 1.00; P = 0.050); and past placental infection (aOR 0.35, 95% CI 0.24, 0.50; P < 0.001). Corresponding increases in the odds of infection were observed with two-fold increases in ferritin levels. There was effect modification of iron-malaria relationships by gravidity. At delivery, ID was associated with reduced odds of peripheral parasitaemia amongst primigravid (AOR 0.44, 95% CI 0.25, 0.76; P = 0.003), but not multigravid women (AOR 1.12, 95% CI 0.61, 2.05; P = 0.720). A two-fold increase in ferritin associated with increased odds of placental blood infection (1.44, 95% CI 1.06, 1.96; P = 0.019) and active placental infection on histology amongst primigravid women only (1.24, 95% CI 1.00, 1.54; P = 0.052). Conclusions Low maternal ferritin at first antenatal visit was associated with a lower risk of malaria infection during pregnancy, most notably in primigravid women. The mechanisms by which maternal iron stores influence susceptibility to infection with Plasmodium species require further investigation. Trial registration |
| first_indexed | 2024-12-12T12:44:50Z |
| format | Article |
| id | doaj.art-89c6e8486cfe4b56b0b1f8cc8091fe76 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-12T12:44:50Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
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| series | Malaria Journal |
| spelling | doaj.art-89c6e8486cfe4b56b0b1f8cc8091fe762022-12-22T00:24:09ZengBMCMalaria Journal1475-28752022-05-0121111110.1186/s12936-022-04177-8Associations of maternal iron deficiency with malaria infection in a cohort of pregnant Papua New Guinean womenHolger W. Unger0Andie Bleicher1Maria Ome-Kaius2Elizabeth H. Aitken3Stephen J. Rogerson4Department of Obstetrics and Gynaecology, Royal Darwin HospitalDepartment of Medicine (RMH), Peter Doherty Institute for Infection and Immunity, The University of MelbournePapua New Guinea Institute of Medical ResearchDepartment of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, The University of MelbourneDepartment of Medicine (RMH), Peter Doherty Institute for Infection and Immunity, The University of MelbourneAbstract Background Iron deficiency (ID) is common in malaria-endemic settings. Intermittent preventative treatment of malaria in pregnancy (IPTp) and iron supplementation are core components of antenatal care in endemic regions to prevent adverse pregnancy outcomes. ID has been associated with reduced risk of malaria infection, and correspondingly, iron supplementation with increased risk of malaria infection, in some studies. Methods A secondary analysis was conducted amongst 1888 pregnant women enrolled in a malaria prevention trial in Papua New Guinea. Maternal ID was defined as inflammation-corrected plasma ferritin levels < 15 μg/L at antenatal enrolment. Malaria burden (Plasmodium falciparum, Plasmodium vivax) was determined by light microscopy, polymerase chain reaction, and placental histology. Multiple logistic and linear regression analyses explored the relationship of ID or ferritin levels with indicators of malaria infection. Models were fitted with interaction terms to assess for modification of iron-malaria relationships by gravidity or treatment arm. Results Two-thirds (n = 1226) and 13.7% (n = 258) of women had ID and peripheral parasitaemia, respectively, at antenatal enrolment (median gestational age: 22 weeks), and 18.7% (120/1,356) had evidence of malaria infection on placental histology. Overall, ID was associated with reduced odds of peripheral parasitaemia at enrolment (adjusted odds ratio [aOR] 0.50; 95% confidence interval [95% CI] 0.38, 0.66, P < 0.001); peripheral parasitaemia at delivery (aOR 0.68, 95% CI 0.46, 1.00; P = 0.050); and past placental infection (aOR 0.35, 95% CI 0.24, 0.50; P < 0.001). Corresponding increases in the odds of infection were observed with two-fold increases in ferritin levels. There was effect modification of iron-malaria relationships by gravidity. At delivery, ID was associated with reduced odds of peripheral parasitaemia amongst primigravid (AOR 0.44, 95% CI 0.25, 0.76; P = 0.003), but not multigravid women (AOR 1.12, 95% CI 0.61, 2.05; P = 0.720). A two-fold increase in ferritin associated with increased odds of placental blood infection (1.44, 95% CI 1.06, 1.96; P = 0.019) and active placental infection on histology amongst primigravid women only (1.24, 95% CI 1.00, 1.54; P = 0.052). Conclusions Low maternal ferritin at first antenatal visit was associated with a lower risk of malaria infection during pregnancy, most notably in primigravid women. The mechanisms by which maternal iron stores influence susceptibility to infection with Plasmodium species require further investigation. Trial registrationhttps://doi.org/10.1186/s12936-022-04177-8Iron deficiencyIron supplementationPlasmodium falciparumPlasmodium vivaxRisk |
| spellingShingle | Holger W. Unger Andie Bleicher Maria Ome-Kaius Elizabeth H. Aitken Stephen J. Rogerson Associations of maternal iron deficiency with malaria infection in a cohort of pregnant Papua New Guinean women Malaria Journal Iron deficiency Iron supplementation Plasmodium falciparum Plasmodium vivax Risk |
| title | Associations of maternal iron deficiency with malaria infection in a cohort of pregnant Papua New Guinean women |
| title_full | Associations of maternal iron deficiency with malaria infection in a cohort of pregnant Papua New Guinean women |
| title_fullStr | Associations of maternal iron deficiency with malaria infection in a cohort of pregnant Papua New Guinean women |
| title_full_unstemmed | Associations of maternal iron deficiency with malaria infection in a cohort of pregnant Papua New Guinean women |
| title_short | Associations of maternal iron deficiency with malaria infection in a cohort of pregnant Papua New Guinean women |
| title_sort | associations of maternal iron deficiency with malaria infection in a cohort of pregnant papua new guinean women |
| topic | Iron deficiency Iron supplementation Plasmodium falciparum Plasmodium vivax Risk |
| url | https://doi.org/10.1186/s12936-022-04177-8 |
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