Metabolic rearrangements and intratumoral heterogeneity for immune response in hepatocellular carcinoma
Liver cancer is one of the most common malignant tumors globally. Not only is it difficult to diagnose, but treatments are scarce and the prognosis is generally poor. Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Aggressive cancer cells, such as those found in HCC, undergo...
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| Format: | Article |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1083069/full |
| _version_ | 1797943584594329600 |
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| author | Fei-Qi Xu Fei-Qi Xu Meng-Meng Dong Zhi-Fei Wang Li-Dong Cao |
| author_facet | Fei-Qi Xu Fei-Qi Xu Meng-Meng Dong Zhi-Fei Wang Li-Dong Cao |
| author_sort | Fei-Qi Xu |
| collection | DOAJ |
| description | Liver cancer is one of the most common malignant tumors globally. Not only is it difficult to diagnose, but treatments are scarce and the prognosis is generally poor. Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Aggressive cancer cells, such as those found in HCC, undergo extensive metabolic rewiring as tumorigenesis, the unique feature, ultimately causes adaptation to the neoplastic microenvironment. Intratumoral heterogeneity (ITH) is defined as the presence of distinct genetic features and different phenotypes in the same tumoral region. ITH, a property unique to malignant cancers, results in differences in many different features of tumors, including, but not limited to, tumor growth and resistance to chemotherapy, which in turn is partly responsible for metabolic reprogramming. Moreover, the different metabolic phenotypes might also activate the immune response to varying degrees and help tumor cells escape detection by the immune system. In this review, we summarize the reprogramming of glucose metabolism and tumoral heterogeneity and their associations that occur in HCC, to obtain a better understanding of the mechanisms of HCC oncogenesis. |
| first_indexed | 2024-04-10T20:26:30Z |
| format | Article |
| id | doaj.art-89c79f96ea39464a932f9208ff3c2696 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T20:26:30Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj.art-89c79f96ea39464a932f9208ff3c26962023-01-25T10:53:42ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-01-011410.3389/fimmu.2023.10830691083069Metabolic rearrangements and intratumoral heterogeneity for immune response in hepatocellular carcinomaFei-Qi Xu0Fei-Qi Xu1Meng-Meng Dong2Zhi-Fei Wang3Li-Dong Cao4General Surgery, Cancer Center, Department of Hepatobiliary and Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaThe Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, ChinaGeneral Surgery, Cancer Center, Department of Hepatobiliary and Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaGeneral Surgery, Cancer Center, Department of Hepatobiliary and Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaLiver cancer is one of the most common malignant tumors globally. Not only is it difficult to diagnose, but treatments are scarce and the prognosis is generally poor. Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Aggressive cancer cells, such as those found in HCC, undergo extensive metabolic rewiring as tumorigenesis, the unique feature, ultimately causes adaptation to the neoplastic microenvironment. Intratumoral heterogeneity (ITH) is defined as the presence of distinct genetic features and different phenotypes in the same tumoral region. ITH, a property unique to malignant cancers, results in differences in many different features of tumors, including, but not limited to, tumor growth and resistance to chemotherapy, which in turn is partly responsible for metabolic reprogramming. Moreover, the different metabolic phenotypes might also activate the immune response to varying degrees and help tumor cells escape detection by the immune system. In this review, we summarize the reprogramming of glucose metabolism and tumoral heterogeneity and their associations that occur in HCC, to obtain a better understanding of the mechanisms of HCC oncogenesis.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1083069/fullmetabolic rearrangementsintratumoral heterogeneityimmune responsehepatocellular carcinomatumor microenvironment |
| spellingShingle | Fei-Qi Xu Fei-Qi Xu Meng-Meng Dong Zhi-Fei Wang Li-Dong Cao Metabolic rearrangements and intratumoral heterogeneity for immune response in hepatocellular carcinoma Frontiers in Immunology metabolic rearrangements intratumoral heterogeneity immune response hepatocellular carcinoma tumor microenvironment |
| title | Metabolic rearrangements and intratumoral heterogeneity for immune response in hepatocellular carcinoma |
| title_full | Metabolic rearrangements and intratumoral heterogeneity for immune response in hepatocellular carcinoma |
| title_fullStr | Metabolic rearrangements and intratumoral heterogeneity for immune response in hepatocellular carcinoma |
| title_full_unstemmed | Metabolic rearrangements and intratumoral heterogeneity for immune response in hepatocellular carcinoma |
| title_short | Metabolic rearrangements and intratumoral heterogeneity for immune response in hepatocellular carcinoma |
| title_sort | metabolic rearrangements and intratumoral heterogeneity for immune response in hepatocellular carcinoma |
| topic | metabolic rearrangements intratumoral heterogeneity immune response hepatocellular carcinoma tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1083069/full |
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