Bi-directional astrocytic regulation of neuronal activity within a network
The concept of a tripartite synapse holds that astrocytes can affect both the pre- and postsynaptic compartments through the Ca2+-dependent release of gliotransmitters. Because astrocytic Ca2+ transients usually last for a few seconds, we assumed that astrocytic regulation of synaptic transmission m...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-11-01
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| Series: | Frontiers in Computational Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncom.2012.00092/full |
| _version_ | 1818668919156637696 |
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| author | Susan Yu Gordleeva Susan Yu Gordleeva Sergey V Stasenko Sergey V Stasenko Alexey V Semyanov Alexey V Semyanov Alexander E Dityatev Alexander E Dityatev Victor B Kazantsev Victor B Kazantsev |
| author_facet | Susan Yu Gordleeva Susan Yu Gordleeva Sergey V Stasenko Sergey V Stasenko Alexey V Semyanov Alexey V Semyanov Alexander E Dityatev Alexander E Dityatev Victor B Kazantsev Victor B Kazantsev |
| author_sort | Susan Yu Gordleeva |
| collection | DOAJ |
| description | The concept of a tripartite synapse holds that astrocytes can affect both the pre- and postsynaptic compartments through the Ca2+-dependent release of gliotransmitters. Because astrocytic Ca2+ transients usually last for a few seconds, we assumed that astrocytic regulation of synaptic transmission may also occur on the scale of seconds. Here, we considered the basic physiological functions of tripartite synapses and investigated astrocytic regulation at the level of neural network activity. The firing dynamics of individual neurons in a spontaneous firing network was described by the Hodgkin-Huxley model. The neurons received excitatory synaptic input driven by the Poisson spike train with variable frequency. The mean field concentration of the released neurotransmitter was used to describe the presynaptic dynamics. The amplitudes of the excitatory postsynaptic currents (PSCs) obeyed the gamma distribution law. In our model, astrocytes depressed the presynaptic release and enhanced the postsynaptic currents. As a result, low frequency synaptic input was suppressed while high frequency input was amplified. The analysis of the neuron spiking frequency as an indicator of network activity revealed that tripartite synaptic transmission dramatically changed the local network operation compared to bipartite synapses. Specifically, the astrocytes supported homeostatic regulation of the network activity by increasing or decreasing firing of the neurons. Thus, the astrocyte activation may modulate a transition of neural network into bistable regime of activity with two stable firing levels and spontaneous transitions between them. |
| first_indexed | 2024-12-17T06:43:58Z |
| format | Article |
| id | doaj.art-89c812b9050d46fa8619105c51bf0918 |
| institution | Directory Open Access Journal |
| issn | 1662-5188 |
| language | English |
| last_indexed | 2024-12-17T06:43:58Z |
| publishDate | 2012-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Computational Neuroscience |
| spelling | doaj.art-89c812b9050d46fa8619105c51bf09182022-12-21T21:59:48ZengFrontiers Media S.A.Frontiers in Computational Neuroscience1662-51882012-11-01610.3389/fncom.2012.0009226220Bi-directional astrocytic regulation of neuronal activity within a networkSusan Yu Gordleeva0Susan Yu Gordleeva1Sergey V Stasenko2Sergey V Stasenko3Alexey V Semyanov4Alexey V Semyanov5Alexander E Dityatev6Alexander E Dityatev7Victor B Kazantsev8Victor B Kazantsev9Institute of Applied Physics of RASState University of Nizhny NovgorodInstitute of Applied Physics of RASState University of Nizhny NovgorodRIKEN Brain Science InstituteState University of Nizhny NovgorodInstituto Italiano di TecnologiaState University of Nizhny NovgorodInstitute of Applied Physics of RASState University of Nizhny NovgorodThe concept of a tripartite synapse holds that astrocytes can affect both the pre- and postsynaptic compartments through the Ca2+-dependent release of gliotransmitters. Because astrocytic Ca2+ transients usually last for a few seconds, we assumed that astrocytic regulation of synaptic transmission may also occur on the scale of seconds. Here, we considered the basic physiological functions of tripartite synapses and investigated astrocytic regulation at the level of neural network activity. The firing dynamics of individual neurons in a spontaneous firing network was described by the Hodgkin-Huxley model. The neurons received excitatory synaptic input driven by the Poisson spike train with variable frequency. The mean field concentration of the released neurotransmitter was used to describe the presynaptic dynamics. The amplitudes of the excitatory postsynaptic currents (PSCs) obeyed the gamma distribution law. In our model, astrocytes depressed the presynaptic release and enhanced the postsynaptic currents. As a result, low frequency synaptic input was suppressed while high frequency input was amplified. The analysis of the neuron spiking frequency as an indicator of network activity revealed that tripartite synaptic transmission dramatically changed the local network operation compared to bipartite synapses. Specifically, the astrocytes supported homeostatic regulation of the network activity by increasing or decreasing firing of the neurons. Thus, the astrocyte activation may modulate a transition of neural network into bistable regime of activity with two stable firing levels and spontaneous transitions between them.http://journal.frontiersin.org/Journal/10.3389/fncom.2012.00092/fullSynaptic TransmissionregulationNeuronastrocyteNeuronal Networktripartite synapse |
| spellingShingle | Susan Yu Gordleeva Susan Yu Gordleeva Sergey V Stasenko Sergey V Stasenko Alexey V Semyanov Alexey V Semyanov Alexander E Dityatev Alexander E Dityatev Victor B Kazantsev Victor B Kazantsev Bi-directional astrocytic regulation of neuronal activity within a network Frontiers in Computational Neuroscience Synaptic Transmission regulation Neuron astrocyte Neuronal Network tripartite synapse |
| title | Bi-directional astrocytic regulation of neuronal activity within a network |
| title_full | Bi-directional astrocytic regulation of neuronal activity within a network |
| title_fullStr | Bi-directional astrocytic regulation of neuronal activity within a network |
| title_full_unstemmed | Bi-directional astrocytic regulation of neuronal activity within a network |
| title_short | Bi-directional astrocytic regulation of neuronal activity within a network |
| title_sort | bi directional astrocytic regulation of neuronal activity within a network |
| topic | Synaptic Transmission regulation Neuron astrocyte Neuronal Network tripartite synapse |
| url | http://journal.frontiersin.org/Journal/10.3389/fncom.2012.00092/full |
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