Intra-Articular Injections of Allogeneic Mesenchymal Stromal Cells vs. High Molecular Weight Hyaluronic Acid in Dogs With Osteoarthritis: Exploratory Data From a Double-Blind, Randomized, Prospective Clinical Trial
This double-blind, randomized, prospective clinical trial was conducted to obtain exploratory data comparing the efficacy of intra-articular allogeneic mesenchymal stem/stromal cells (MSC) to high molecular weight hyaluronic acid (HA) for the treatment of pain associated with canine osteoarthritis (...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.890704/full |
| _version_ | 1828782186246963200 |
|---|---|
| author | Sohyun Kim Lindsay Elam Valerie Johnson Ann Hess Tracy Webb Steven Dow Felix Duerr |
| author_facet | Sohyun Kim Lindsay Elam Valerie Johnson Ann Hess Tracy Webb Steven Dow Felix Duerr |
| author_sort | Sohyun Kim |
| collection | DOAJ |
| description | This double-blind, randomized, prospective clinical trial was conducted to obtain exploratory data comparing the efficacy of intra-articular allogeneic mesenchymal stem/stromal cells (MSC) to high molecular weight hyaluronic acid (HA) for the treatment of pain associated with canine osteoarthritis (OA). Objective gait analysis (%Body Weight Distribution, %BWD), accelerometry, clinical metrology instruments and veterinary exams were used as outcome measures during various time points throughout the 48-week study period. Fourteen dogs with elbow or coxofemoral OA were enrolled and assigned in a 2:1 ratio to the treatment groups. Each patient received a set of two injections 4 weeks apart. Self-limiting joint flare was observed in seven patients, with six of these in the MSC group. Ten patients completed all follow-up appointments. Both treatment groups showed evidence of mild improvement following the treatment, but the results were inconsistent among the various outcome measures assessed. Overall, dogs enrolled in the HA group showed greater improvement compared to the MSC group. The primary outcome measure, %BWD, showed evidence of improvement, when compared to baseline values, at 36 weeks after injection for the HA group only (p = 0.048, estimated difference: 4.7). Similarly, when treatment groups were compared, evidence of a difference between treatment groups (with the HA-group showing greater improvement) were identified for weeks 24 and 36 (p = 0.02 and 0.01, respectively). The small sample size of this exploratory study does not allow firm conclusions. However, until studies with larger sample sizes are available, the current literature combined with our data do not support the clinical use of intra-articular MSC therapy over high molecular weight HA for the treatment of canine OA at this time. |
| first_indexed | 2024-12-11T17:45:45Z |
| format | Article |
| id | doaj.art-89c97445dc28406f8b3124b3bb90dde3 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-12-11T17:45:45Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-89c97445dc28406f8b3124b3bb90dde32022-12-22T00:56:24ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-06-01910.3389/fvets.2022.890704890704Intra-Articular Injections of Allogeneic Mesenchymal Stromal Cells vs. High Molecular Weight Hyaluronic Acid in Dogs With Osteoarthritis: Exploratory Data From a Double-Blind, Randomized, Prospective Clinical TrialSohyun Kim0Lindsay Elam1Valerie Johnson2Ann Hess3Tracy Webb4Steven Dow5Felix Duerr6Department of Clinical Sciences, Colorado State University College of Veterinary Medicine and Biomedical Sciences, Fort Collins, CO, United StatesDepartment of Clinical Sciences, Colorado State University College of Veterinary Medicine and Biomedical Sciences, Fort Collins, CO, United StatesDepartment of Clinical Sciences, Colorado State University College of Veterinary Medicine and Biomedical Sciences, Fort Collins, CO, United StatesDepartment of Statistics, Colorado State University, Fort Collins, CO, United StatesDepartment of Clinical Sciences, Colorado State University College of Veterinary Medicine and Biomedical Sciences, Fort Collins, CO, United StatesDepartment of Clinical Sciences, Colorado State University College of Veterinary Medicine and Biomedical Sciences, Fort Collins, CO, United StatesDepartment of Clinical Sciences, Colorado State University College of Veterinary Medicine and Biomedical Sciences, Fort Collins, CO, United StatesThis double-blind, randomized, prospective clinical trial was conducted to obtain exploratory data comparing the efficacy of intra-articular allogeneic mesenchymal stem/stromal cells (MSC) to high molecular weight hyaluronic acid (HA) for the treatment of pain associated with canine osteoarthritis (OA). Objective gait analysis (%Body Weight Distribution, %BWD), accelerometry, clinical metrology instruments and veterinary exams were used as outcome measures during various time points throughout the 48-week study period. Fourteen dogs with elbow or coxofemoral OA were enrolled and assigned in a 2:1 ratio to the treatment groups. Each patient received a set of two injections 4 weeks apart. Self-limiting joint flare was observed in seven patients, with six of these in the MSC group. Ten patients completed all follow-up appointments. Both treatment groups showed evidence of mild improvement following the treatment, but the results were inconsistent among the various outcome measures assessed. Overall, dogs enrolled in the HA group showed greater improvement compared to the MSC group. The primary outcome measure, %BWD, showed evidence of improvement, when compared to baseline values, at 36 weeks after injection for the HA group only (p = 0.048, estimated difference: 4.7). Similarly, when treatment groups were compared, evidence of a difference between treatment groups (with the HA-group showing greater improvement) were identified for weeks 24 and 36 (p = 0.02 and 0.01, respectively). The small sample size of this exploratory study does not allow firm conclusions. However, until studies with larger sample sizes are available, the current literature combined with our data do not support the clinical use of intra-articular MSC therapy over high molecular weight HA for the treatment of canine OA at this time.https://www.frontiersin.org/articles/10.3389/fvets.2022.890704/fullosteoarthritisdogstem cell therapeuticshyaluronic acidregenerative medicine |
| spellingShingle | Sohyun Kim Lindsay Elam Valerie Johnson Ann Hess Tracy Webb Steven Dow Felix Duerr Intra-Articular Injections of Allogeneic Mesenchymal Stromal Cells vs. High Molecular Weight Hyaluronic Acid in Dogs With Osteoarthritis: Exploratory Data From a Double-Blind, Randomized, Prospective Clinical Trial Frontiers in Veterinary Science osteoarthritis dog stem cell therapeutics hyaluronic acid regenerative medicine |
| title | Intra-Articular Injections of Allogeneic Mesenchymal Stromal Cells vs. High Molecular Weight Hyaluronic Acid in Dogs With Osteoarthritis: Exploratory Data From a Double-Blind, Randomized, Prospective Clinical Trial |
| title_full | Intra-Articular Injections of Allogeneic Mesenchymal Stromal Cells vs. High Molecular Weight Hyaluronic Acid in Dogs With Osteoarthritis: Exploratory Data From a Double-Blind, Randomized, Prospective Clinical Trial |
| title_fullStr | Intra-Articular Injections of Allogeneic Mesenchymal Stromal Cells vs. High Molecular Weight Hyaluronic Acid in Dogs With Osteoarthritis: Exploratory Data From a Double-Blind, Randomized, Prospective Clinical Trial |
| title_full_unstemmed | Intra-Articular Injections of Allogeneic Mesenchymal Stromal Cells vs. High Molecular Weight Hyaluronic Acid in Dogs With Osteoarthritis: Exploratory Data From a Double-Blind, Randomized, Prospective Clinical Trial |
| title_short | Intra-Articular Injections of Allogeneic Mesenchymal Stromal Cells vs. High Molecular Weight Hyaluronic Acid in Dogs With Osteoarthritis: Exploratory Data From a Double-Blind, Randomized, Prospective Clinical Trial |
| title_sort | intra articular injections of allogeneic mesenchymal stromal cells vs high molecular weight hyaluronic acid in dogs with osteoarthritis exploratory data from a double blind randomized prospective clinical trial |
| topic | osteoarthritis dog stem cell therapeutics hyaluronic acid regenerative medicine |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.890704/full |
| work_keys_str_mv | AT sohyunkim intraarticularinjectionsofallogeneicmesenchymalstromalcellsvshighmolecularweighthyaluronicacidindogswithosteoarthritisexploratorydatafromadoubleblindrandomizedprospectiveclinicaltrial AT lindsayelam intraarticularinjectionsofallogeneicmesenchymalstromalcellsvshighmolecularweighthyaluronicacidindogswithosteoarthritisexploratorydatafromadoubleblindrandomizedprospectiveclinicaltrial AT valeriejohnson intraarticularinjectionsofallogeneicmesenchymalstromalcellsvshighmolecularweighthyaluronicacidindogswithosteoarthritisexploratorydatafromadoubleblindrandomizedprospectiveclinicaltrial AT annhess intraarticularinjectionsofallogeneicmesenchymalstromalcellsvshighmolecularweighthyaluronicacidindogswithosteoarthritisexploratorydatafromadoubleblindrandomizedprospectiveclinicaltrial AT tracywebb intraarticularinjectionsofallogeneicmesenchymalstromalcellsvshighmolecularweighthyaluronicacidindogswithosteoarthritisexploratorydatafromadoubleblindrandomizedprospectiveclinicaltrial AT stevendow intraarticularinjectionsofallogeneicmesenchymalstromalcellsvshighmolecularweighthyaluronicacidindogswithosteoarthritisexploratorydatafromadoubleblindrandomizedprospectiveclinicaltrial AT felixduerr intraarticularinjectionsofallogeneicmesenchymalstromalcellsvshighmolecularweighthyaluronicacidindogswithosteoarthritisexploratorydatafromadoubleblindrandomizedprospectiveclinicaltrial |