Revisiting misfolding propensity of serum amyloid A1: Special focus on the signal peptide region

Revisiting misfolding propensity of serum amyloid A1: Special focus on the signal peptide region

AA amyloidosis is the result of overproduction and aberrant processing of acute-phase serum amyloid A1 (SAA1) by hepatocytes. Proteolytic cleavage of SAA1 is believed to play a central role in AA amyloid formation. The SAA1 protein undergoes a cleavage of 18 residues consisting of the signal peptide...

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Bibliographic Details
Main Authors: Morgan S. Haines, Eduardo Ramirez, Kendall B.E. Moore, Jessica S. Fortin
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
Amyloid A
Fibril assembly
Protein misfolding
Serum amyloid A
Signal peptide
Systemic amyloidosis
Online Access:http://www.sciencedirect.com/science/article/pii/S240558082200084X

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