Multivariate Independent Component Analysis Identifies Patients in Newborn Screening Equally to Adjusted Reference Ranges

Multivariate Independent Component Analysis Identifies Patients in Newborn Screening Equally to Adjusted Reference Ranges

Newborn screening (NBS) of inborn errors of metabolism (IEMs) is based on the reference ranges established on a healthy newborn population using quantile statistics of molar concentrations of biomarkers and their ratios. The aim of this paper is to investigate whether multivariate independent compon...

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Bibliographic Details
Main Authors: Štěpán Kouřil, Julie de Sousa, Kamila Fačevicová, Alžběta Gardlo, Christoph Muehlmann, Klaus Nordhausen, David Friedecký, Tomáš Adam
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Neonatal Screening
Subjects:
newborn screening
independent component analysis
mass spectrometry
multivariate statistical analysis
inborn errors of metabolism
compositional data analysis
Online Access:https://www.mdpi.com/2409-515X/9/4/60

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