Exploring the Genetic Conception of Obesity via the Dual Role of FoxO
Obesity or overweight are not superficial problems, constituting a pressing issue. The obesity index has almost tripled since 1975, which is an alarming state. Most of the individuals are currently becoming overweight or have inappropriate body mass index (BMI) conditions. Obesity is characterized b...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-03-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/6/3179 |
| _version_ | 1797540634861502464 |
|---|---|
| author | Tapan Behl Ishnoor Kaur Aayush Sehgal Sukhbir Singh Gokhan Zengin Nicoleta Negrut Delia Carmen Nistor-Cseppento Flavia Maria Pavel Raluca Anca Corb Aron Simona Bungau |
| author_facet | Tapan Behl Ishnoor Kaur Aayush Sehgal Sukhbir Singh Gokhan Zengin Nicoleta Negrut Delia Carmen Nistor-Cseppento Flavia Maria Pavel Raluca Anca Corb Aron Simona Bungau |
| author_sort | Tapan Behl |
| collection | DOAJ |
| description | Obesity or overweight are not superficial problems, constituting a pressing issue. The obesity index has almost tripled since 1975, which is an alarming state. Most of the individuals are currently becoming overweight or have inappropriate body mass index (BMI) conditions. Obesity is characterized by increased fat accumulation and thus poses a higher health risk. There is increased size and volume of fat cells in the body, which usually accounts for obesity. Many investigations have been carried out in this area, such as behavioral improvements, dietary changes, chemical involvements, etc., but presently no such goals are established to manage these health concerns. Based on previous literature reports and our interpretation, the current review indicates the involvement of various transcriptional and transporter functions in modifying the above-mentioned health conditions. Various transcriptional factors such as Forkhead box O1 (FoxO1) impart a significant effect on the physiology and pathology of metabolic dysfunction such as obesity. FoxO1 plays a dual role whether in the progression or suppression of metabolic processes depending on its targets. Thus, in the current study, will be discussed the dual role of FoxO1 in metabolic conditions (such as obesity), also summarizing the role of various other transcriptional factors involved in obesity. |
| first_indexed | 2024-03-10T13:03:02Z |
| format | Article |
| id | doaj.art-89cd9cb01bd241fe969a41485a10d3dd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:03:02Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-89cd9cb01bd241fe969a41485a10d3dd2023-11-21T11:19:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01226317910.3390/ijms22063179Exploring the Genetic Conception of Obesity via the Dual Role of FoxOTapan Behl0Ishnoor Kaur1Aayush Sehgal2Sukhbir Singh3Gokhan Zengin4Nicoleta Negrut5Delia Carmen Nistor-Cseppento6Flavia Maria Pavel7Raluca Anca Corb Aron8Simona Bungau9Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Punjab 140401, IndiaDepartment of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Punjab 140401, IndiaDepartment of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Punjab 140401, IndiaDepartment of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Punjab 140401, IndiaDepartment of Biology, Faculty of Science, Selcuk University Campus, Konya 42130, TurkeyDepartment of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, RomaniaDepartment of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, RomaniaDepartment of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, RomaniaDepartment of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, RomaniaObesity or overweight are not superficial problems, constituting a pressing issue. The obesity index has almost tripled since 1975, which is an alarming state. Most of the individuals are currently becoming overweight or have inappropriate body mass index (BMI) conditions. Obesity is characterized by increased fat accumulation and thus poses a higher health risk. There is increased size and volume of fat cells in the body, which usually accounts for obesity. Many investigations have been carried out in this area, such as behavioral improvements, dietary changes, chemical involvements, etc., but presently no such goals are established to manage these health concerns. Based on previous literature reports and our interpretation, the current review indicates the involvement of various transcriptional and transporter functions in modifying the above-mentioned health conditions. Various transcriptional factors such as Forkhead box O1 (FoxO1) impart a significant effect on the physiology and pathology of metabolic dysfunction such as obesity. FoxO1 plays a dual role whether in the progression or suppression of metabolic processes depending on its targets. Thus, in the current study, will be discussed the dual role of FoxO1 in metabolic conditions (such as obesity), also summarizing the role of various other transcriptional factors involved in obesity.https://www.mdpi.com/1422-0067/22/6/3179obesitymetabolic syndromesFoxOAKT pathwayoxidative stressinsulin |
| spellingShingle | Tapan Behl Ishnoor Kaur Aayush Sehgal Sukhbir Singh Gokhan Zengin Nicoleta Negrut Delia Carmen Nistor-Cseppento Flavia Maria Pavel Raluca Anca Corb Aron Simona Bungau Exploring the Genetic Conception of Obesity via the Dual Role of FoxO International Journal of Molecular Sciences obesity metabolic syndromes FoxO AKT pathway oxidative stress insulin |
| title | Exploring the Genetic Conception of Obesity via the Dual Role of FoxO |
| title_full | Exploring the Genetic Conception of Obesity via the Dual Role of FoxO |
| title_fullStr | Exploring the Genetic Conception of Obesity via the Dual Role of FoxO |
| title_full_unstemmed | Exploring the Genetic Conception of Obesity via the Dual Role of FoxO |
| title_short | Exploring the Genetic Conception of Obesity via the Dual Role of FoxO |
| title_sort | exploring the genetic conception of obesity via the dual role of foxo |
| topic | obesity metabolic syndromes FoxO AKT pathway oxidative stress insulin |
| url | https://www.mdpi.com/1422-0067/22/6/3179 |
| work_keys_str_mv | AT tapanbehl exploringthegeneticconceptionofobesityviathedualroleoffoxo AT ishnoorkaur exploringthegeneticconceptionofobesityviathedualroleoffoxo AT aayushsehgal exploringthegeneticconceptionofobesityviathedualroleoffoxo AT sukhbirsingh exploringthegeneticconceptionofobesityviathedualroleoffoxo AT gokhanzengin exploringthegeneticconceptionofobesityviathedualroleoffoxo AT nicoletanegrut exploringthegeneticconceptionofobesityviathedualroleoffoxo AT deliacarmennistorcseppento exploringthegeneticconceptionofobesityviathedualroleoffoxo AT flaviamariapavel exploringthegeneticconceptionofobesityviathedualroleoffoxo AT ralucaancacorbaron exploringthegeneticconceptionofobesityviathedualroleoffoxo AT simonabungau exploringthegeneticconceptionofobesityviathedualroleoffoxo |