Probability of sequelae following Campylobacter spp. infections: Update of systematic reviews and meta‐analyses
Abstract Introduction Reactive arthritis (REA) and Guillain–Barré syndrome (GBS) are postinfectious complications of Campylobacter enteritis (CE); associations with inflammatory bowel diseases and irritable bowel syndrome (IBS) are also discussed. The objective of this study was to summarize existin...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-12-01
|
| Series: | Public Health Challenges |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/puh2.145 |
| _version_ | 1797372377102811136 |
|---|---|
| author | Elisabeth Schorling Sebastian Knorr Sonja Lick Pablo Steinberg Dagmar Adeline Brüggemann |
| author_facet | Elisabeth Schorling Sebastian Knorr Sonja Lick Pablo Steinberg Dagmar Adeline Brüggemann |
| author_sort | Elisabeth Schorling |
| collection | DOAJ |
| description | Abstract Introduction Reactive arthritis (REA) and Guillain–Barré syndrome (GBS) are postinfectious complications of Campylobacter enteritis (CE); associations with inflammatory bowel diseases and irritable bowel syndrome (IBS) are also discussed. The objective of this study was to summarize existing evidence on the probability of sequelae following confirmed CE. Methods All studies included in previous reviews and meta‐analyses on this topic were retrieved and assessed for eligibility; a systematic literature search was conducted to collect more recent reports. For each sequela, random effects meta‐analyses were performed; the risk of bias and the quality of evidence were evaluated. Results In total, 50 reports of observational studies were included; between 110,765 and 175,839 CE cases were considered for each sequela. The pooled proportion of CE cases that developed a sequela was 1.72% (95% CI 0.81–3.61; prediction interval [PI]: 0.03–47.65) for REA, 0.07% (0.03–0.16; PI: 0.003–1.59) for GBS, 0.22% (0.06–0.73; PI: 0.002–20.69) for Crohn's disease (CD), 0.35% (0.11–1.15; PI: 0.003–28.16) for ulcerative colitis (UC), and 4.48% (1.92–10.08; PI: 0.09–70.62) for IBS. The high between‐study heterogeneity could partially be explained by study size and design, the method of assessing sequelae, and the period between CE and sequelae onset. The quality of evidence was rated as moderate for GBS and UC, and low for REA, CD, and IBS. Conclusion Updated estimates of the probability to develop sequelae after CE are provided, for CD and UC for the first time. However, uncertainty regarding the true probabilities remains, which is reflected in the broad PIs. |
| first_indexed | 2024-03-08T18:33:47Z |
| format | Article |
| id | doaj.art-89cf729586e34acb8ff62513c8017ffe |
| institution | Directory Open Access Journal |
| issn | 2769-2450 |
| language | English |
| last_indexed | 2024-03-08T18:33:47Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Public Health Challenges |
| spelling | doaj.art-89cf729586e34acb8ff62513c8017ffe2023-12-29T16:48:31ZengWileyPublic Health Challenges2769-24502023-12-0124n/an/a10.1002/puh2.145Probability of sequelae following Campylobacter spp. infections: Update of systematic reviews and meta‐analysesElisabeth Schorling0Sebastian Knorr1Sonja Lick2Pablo Steinberg3Dagmar Adeline Brüggemann4Department of Safety and Quality of Meat Max Rubner‐Institut, Federal Research Institute of Nutrition and Food Kulmbach Bavaria GermanyDepartment of Safety and Quality of Meat Max Rubner‐Institut, Federal Research Institute of Nutrition and Food Kulmbach Bavaria GermanyDepartment of Safety and Quality of Meat Max Rubner‐Institut, Federal Research Institute of Nutrition and Food Kulmbach Bavaria GermanyMax Rubner‐Institut, Federal Research Institute of Nutrition and Food Karlsruhe Baden‐Wurttemberg GermanyDepartment of Safety and Quality of Meat Max Rubner‐Institut, Federal Research Institute of Nutrition and Food Kulmbach Bavaria GermanyAbstract Introduction Reactive arthritis (REA) and Guillain–Barré syndrome (GBS) are postinfectious complications of Campylobacter enteritis (CE); associations with inflammatory bowel diseases and irritable bowel syndrome (IBS) are also discussed. The objective of this study was to summarize existing evidence on the probability of sequelae following confirmed CE. Methods All studies included in previous reviews and meta‐analyses on this topic were retrieved and assessed for eligibility; a systematic literature search was conducted to collect more recent reports. For each sequela, random effects meta‐analyses were performed; the risk of bias and the quality of evidence were evaluated. Results In total, 50 reports of observational studies were included; between 110,765 and 175,839 CE cases were considered for each sequela. The pooled proportion of CE cases that developed a sequela was 1.72% (95% CI 0.81–3.61; prediction interval [PI]: 0.03–47.65) for REA, 0.07% (0.03–0.16; PI: 0.003–1.59) for GBS, 0.22% (0.06–0.73; PI: 0.002–20.69) for Crohn's disease (CD), 0.35% (0.11–1.15; PI: 0.003–28.16) for ulcerative colitis (UC), and 4.48% (1.92–10.08; PI: 0.09–70.62) for IBS. The high between‐study heterogeneity could partially be explained by study size and design, the method of assessing sequelae, and the period between CE and sequelae onset. The quality of evidence was rated as moderate for GBS and UC, and low for REA, CD, and IBS. Conclusion Updated estimates of the probability to develop sequelae after CE are provided, for CD and UC for the first time. However, uncertainty regarding the true probabilities remains, which is reflected in the broad PIs.https://doi.org/10.1002/puh2.145arthritis, reactiveCampylobacter infectionsGuillain–Barré syndromeinflammatory bowel diseasesirritable bowel syndromemeta‐analysis |
| spellingShingle | Elisabeth Schorling Sebastian Knorr Sonja Lick Pablo Steinberg Dagmar Adeline Brüggemann Probability of sequelae following Campylobacter spp. infections: Update of systematic reviews and meta‐analyses Public Health Challenges arthritis, reactive Campylobacter infections Guillain–Barré syndrome inflammatory bowel diseases irritable bowel syndrome meta‐analysis |
| title | Probability of sequelae following Campylobacter spp. infections: Update of systematic reviews and meta‐analyses |
| title_full | Probability of sequelae following Campylobacter spp. infections: Update of systematic reviews and meta‐analyses |
| title_fullStr | Probability of sequelae following Campylobacter spp. infections: Update of systematic reviews and meta‐analyses |
| title_full_unstemmed | Probability of sequelae following Campylobacter spp. infections: Update of systematic reviews and meta‐analyses |
| title_short | Probability of sequelae following Campylobacter spp. infections: Update of systematic reviews and meta‐analyses |
| title_sort | probability of sequelae following campylobacter spp infections update of systematic reviews and meta analyses |
| topic | arthritis, reactive Campylobacter infections Guillain–Barré syndrome inflammatory bowel diseases irritable bowel syndrome meta‐analysis |
| url | https://doi.org/10.1002/puh2.145 |
| work_keys_str_mv | AT elisabethschorling probabilityofsequelaefollowingcampylobactersppinfectionsupdateofsystematicreviewsandmetaanalyses AT sebastianknorr probabilityofsequelaefollowingcampylobactersppinfectionsupdateofsystematicreviewsandmetaanalyses AT sonjalick probabilityofsequelaefollowingcampylobactersppinfectionsupdateofsystematicreviewsandmetaanalyses AT pablosteinberg probabilityofsequelaefollowingcampylobactersppinfectionsupdateofsystematicreviewsandmetaanalyses AT dagmaradelinebruggemann probabilityofsequelaefollowingcampylobactersppinfectionsupdateofsystematicreviewsandmetaanalyses |