Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis.
BACKGROUND:Reduced white matter (WM) integrity is a fundamental aspect of pediatric multiple sclerosis (MS), though relations to resting-state functional MRI (fMRI) connectivity remain unknown. The objective of this study was to relate diffusion-tensor imaging (DTI) measures of WM microstructural in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4701472?pdf=render |
| _version_ | 1818063826249056256 |
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| author | Nadine Akbar Antonio Giorgio Christine Till John G Sled Sam M Doesburg Nicola De Stefano Brenda Banwell |
| author_facet | Nadine Akbar Antonio Giorgio Christine Till John G Sled Sam M Doesburg Nicola De Stefano Brenda Banwell |
| author_sort | Nadine Akbar |
| collection | DOAJ |
| description | BACKGROUND:Reduced white matter (WM) integrity is a fundamental aspect of pediatric multiple sclerosis (MS), though relations to resting-state functional MRI (fMRI) connectivity remain unknown. The objective of this study was to relate diffusion-tensor imaging (DTI) measures of WM microstructural integrity to resting-state network (RSN) functional connectivity in pediatric-onset MS to test the hypothesis that abnormalities in RSN reflects changes in structural integrity. METHODS:This study enrolled 19 patients with pediatric-onset MS (mean age = 19, range 13-24 years, 14 female, mean disease duration = 65 months, mean age of disease onset = 13 years) and 16 age- and sex-matched healthy controls (HC). All subjects underwent 3.0T anatomical and functional MRI which included DTI and resting-state acquisitions. DTI processing was performed using Tract-Based Spatial Statistics (TBSS). RSNs were identified using Independent Components Analysis, and a dual regression technique was used to detect between-group differences in the functional connectivity of RSNs. Correlations were investigated between DTI measures and RSN connectivity. RESULTS:Lower fractional anisotropy (FA) was observed in the pediatric-onset MS group compared to HC group within the entire WM skeleton, and particularly the corpus callosum, posterior thalamic radiation, corona radiata and sagittal stratum (all p < .01, corrected). Relative to HCs, MS patients showed higher functional connectivity involving the anterior cingulate cortex and right precuneus of the default-mode network, as well as involving the anterior cingulate cortex and left middle frontal gyrus of the frontoparietal network (all p < .005 uncorrected, k≥30 voxels). Higher functional connectivity of the right precuneus within the default-mode network was associated with lower FA of the entire WM skeleton (r = -.525, p = .02), genu of the corpus callosum (r = -.553, p = .014), and left (r = -.467, p = .044) and right (r = -.615, p = .005) sagittal stratum. CONCLUSIONS:Loss of WM microstructural integrity is associated with increased resting-state functional connectivity in pediatric MS, which may reflect a diffuse and potentially compensatory activation early in MS. |
| first_indexed | 2024-12-10T14:26:16Z |
| format | Article |
| id | doaj.art-89cf7cae47234bff94d60c736cef457c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T14:26:16Z |
| publishDate | 2016-01-01 |
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| spelling | doaj.art-89cf7cae47234bff94d60c736cef457c2022-12-22T01:45:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01111e014590610.1371/journal.pone.0145906Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis.Nadine AkbarAntonio GiorgioChristine TillJohn G SledSam M DoesburgNicola De StefanoBrenda BanwellBACKGROUND:Reduced white matter (WM) integrity is a fundamental aspect of pediatric multiple sclerosis (MS), though relations to resting-state functional MRI (fMRI) connectivity remain unknown. The objective of this study was to relate diffusion-tensor imaging (DTI) measures of WM microstructural integrity to resting-state network (RSN) functional connectivity in pediatric-onset MS to test the hypothesis that abnormalities in RSN reflects changes in structural integrity. METHODS:This study enrolled 19 patients with pediatric-onset MS (mean age = 19, range 13-24 years, 14 female, mean disease duration = 65 months, mean age of disease onset = 13 years) and 16 age- and sex-matched healthy controls (HC). All subjects underwent 3.0T anatomical and functional MRI which included DTI and resting-state acquisitions. DTI processing was performed using Tract-Based Spatial Statistics (TBSS). RSNs were identified using Independent Components Analysis, and a dual regression technique was used to detect between-group differences in the functional connectivity of RSNs. Correlations were investigated between DTI measures and RSN connectivity. RESULTS:Lower fractional anisotropy (FA) was observed in the pediatric-onset MS group compared to HC group within the entire WM skeleton, and particularly the corpus callosum, posterior thalamic radiation, corona radiata and sagittal stratum (all p < .01, corrected). Relative to HCs, MS patients showed higher functional connectivity involving the anterior cingulate cortex and right precuneus of the default-mode network, as well as involving the anterior cingulate cortex and left middle frontal gyrus of the frontoparietal network (all p < .005 uncorrected, k≥30 voxels). Higher functional connectivity of the right precuneus within the default-mode network was associated with lower FA of the entire WM skeleton (r = -.525, p = .02), genu of the corpus callosum (r = -.553, p = .014), and left (r = -.467, p = .044) and right (r = -.615, p = .005) sagittal stratum. CONCLUSIONS:Loss of WM microstructural integrity is associated with increased resting-state functional connectivity in pediatric MS, which may reflect a diffuse and potentially compensatory activation early in MS.http://europepmc.org/articles/PMC4701472?pdf=render |
| spellingShingle | Nadine Akbar Antonio Giorgio Christine Till John G Sled Sam M Doesburg Nicola De Stefano Brenda Banwell Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis. PLoS ONE |
| title | Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis. |
| title_full | Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis. |
| title_fullStr | Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis. |
| title_full_unstemmed | Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis. |
| title_short | Alterations in Functional and Structural Connectivity in Pediatric-Onset Multiple Sclerosis. |
| title_sort | alterations in functional and structural connectivity in pediatric onset multiple sclerosis |
| url | http://europepmc.org/articles/PMC4701472?pdf=render |
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