Improvement mechanism of lipid metabolism and gut microbiota in obese mice with Thunnus albacares eggs yolk glycoprotein
Thunnus albacares (T.albacares) is plentiful with a promising research value and application. However, research on lipid-reducing activity and gut microbiota of T.albacares eggs yolk glycoprotein (TGP) remains unreported. In this work, we investigated the potential mechanism of TGP intervention to i...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624000598 |
| _version_ | 1827329816604442624 |
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| author | Shiwei Yao Yaqi Zhong Yijing Cai Hui Chen Xingwei Xiang Yufang Zhou Lin Chen |
| author_facet | Shiwei Yao Yaqi Zhong Yijing Cai Hui Chen Xingwei Xiang Yufang Zhou Lin Chen |
| author_sort | Shiwei Yao |
| collection | DOAJ |
| description | Thunnus albacares (T.albacares) is plentiful with a promising research value and application. However, research on lipid-reducing activity and gut microbiota of T.albacares eggs yolk glycoprotein (TGP) remains unreported. In this work, we investigated the potential mechanism of TGP intervention to improve the disorders of lipid metabolism, and regulate gut microbiota in mice induced by high-fat diet (HFD). The results demonstrated that TGP improved the dyslipidemia, liver inflammation, and restored the liver tissue structure caused by HFD. TGP prevented lipid overaccumulation by downregulating the relative mRNA expression of lipid synthesis genes. TGP also prevented differential expansion of microbiota, increased the abundance of beneficial bacteria Lactobacillus and Akkermansia, and decreased the abundance of harmful bacteria Desulfovibrio. Moreover, TGP promoted the production of short-chain fatty acids (SCFAs). All the above results provided some theoretical basis for the in-depth development and application of TGP as a functional food for obesity and hyperlipidemia. |
| first_indexed | 2024-03-07T15:47:37Z |
| format | Article |
| id | doaj.art-89cfd101b5624710b0760dcb0e861a62 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-07T15:47:37Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-89cfd101b5624710b0760dcb0e861a622024-03-05T04:29:35ZengElsevierJournal of Functional Foods1756-46462024-03-01114106057Improvement mechanism of lipid metabolism and gut microbiota in obese mice with Thunnus albacares eggs yolk glycoproteinShiwei Yao0Yaqi Zhong1Yijing Cai2Hui Chen3Xingwei Xiang4Yufang Zhou5Lin Chen6College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China; Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Hangzhou 310014, China; National R&D Branch Center for Pelagic Aquatic Products Processing (Hangzhou), Hangzhou 310014, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, ChinaFood and Pharmacy College, Zhejiang Ocean University, Zhoushan 316000, ChinaFood and Pharmacy College, Zhejiang Ocean University, Zhoushan 316000, ChinaCollege of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China; Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Hangzhou 310014, China; National R&D Branch Center for Pelagic Aquatic Products Processing (Hangzhou), Hangzhou 310014, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, ChinaCollege of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China; Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Hangzhou 310014, China; National R&D Branch Center for Pelagic Aquatic Products Processing (Hangzhou), Hangzhou 310014, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China; Corresponding authors at: College of Food Science and Technology, Zhejiang University of Technology, Hangzhou Zhejiang 310014, China (X. Xiang). Zhejiang Marine Development Research Institute, Zhoushan 316000, China (Y. Zhou).Zhejiang Marine Development Research Institute, Zhoushan 316000, China; Food and Pharmacy College, Zhejiang Ocean University, Zhoushan 316000, China; Corresponding authors at: College of Food Science and Technology, Zhejiang University of Technology, Hangzhou Zhejiang 310014, China (X. Xiang). Zhejiang Marine Development Research Institute, Zhoushan 316000, China (Y. Zhou).Institute of Sericultural and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou Zhejiang 310021, China; Corresponding authors at: College of Food Science and Technology, Zhejiang University of Technology, Hangzhou Zhejiang 310014, China (X. Xiang). Zhejiang Marine Development Research Institute, Zhoushan 316000, China (Y. Zhou).Thunnus albacares (T.albacares) is plentiful with a promising research value and application. However, research on lipid-reducing activity and gut microbiota of T.albacares eggs yolk glycoprotein (TGP) remains unreported. In this work, we investigated the potential mechanism of TGP intervention to improve the disorders of lipid metabolism, and regulate gut microbiota in mice induced by high-fat diet (HFD). The results demonstrated that TGP improved the dyslipidemia, liver inflammation, and restored the liver tissue structure caused by HFD. TGP prevented lipid overaccumulation by downregulating the relative mRNA expression of lipid synthesis genes. TGP also prevented differential expansion of microbiota, increased the abundance of beneficial bacteria Lactobacillus and Akkermansia, and decreased the abundance of harmful bacteria Desulfovibrio. Moreover, TGP promoted the production of short-chain fatty acids (SCFAs). All the above results provided some theoretical basis for the in-depth development and application of TGP as a functional food for obesity and hyperlipidemia.http://www.sciencedirect.com/science/article/pii/S1756464624000598Thunnus albacares eggs yolk glycoproteinLipid metabolismGut microbiotaObesityHyperlipidemia |
| spellingShingle | Shiwei Yao Yaqi Zhong Yijing Cai Hui Chen Xingwei Xiang Yufang Zhou Lin Chen Improvement mechanism of lipid metabolism and gut microbiota in obese mice with Thunnus albacares eggs yolk glycoprotein Journal of Functional Foods Thunnus albacares eggs yolk glycoprotein Lipid metabolism Gut microbiota Obesity Hyperlipidemia |
| title | Improvement mechanism of lipid metabolism and gut microbiota in obese mice with Thunnus albacares eggs yolk glycoprotein |
| title_full | Improvement mechanism of lipid metabolism and gut microbiota in obese mice with Thunnus albacares eggs yolk glycoprotein |
| title_fullStr | Improvement mechanism of lipid metabolism and gut microbiota in obese mice with Thunnus albacares eggs yolk glycoprotein |
| title_full_unstemmed | Improvement mechanism of lipid metabolism and gut microbiota in obese mice with Thunnus albacares eggs yolk glycoprotein |
| title_short | Improvement mechanism of lipid metabolism and gut microbiota in obese mice with Thunnus albacares eggs yolk glycoprotein |
| title_sort | improvement mechanism of lipid metabolism and gut microbiota in obese mice with thunnus albacares eggs yolk glycoprotein |
| topic | Thunnus albacares eggs yolk glycoprotein Lipid metabolism Gut microbiota Obesity Hyperlipidemia |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624000598 |
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