Comorbidities of Chronic Urticaria: A glimpse into a complex relationship
Chronic Urticaria (CU) is a chronic inflammatory, predominantly mast cell-driven disease, characterized by the development of wheals and/or angioedema for more than 6 weeks. It affects approximately 1%–5% of the total population worldwide and imposes a substantial burden on health-related quality of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Allergy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2022.1008145/full |
| _version_ | 1811224316358950912 |
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| author | Niki Papapostolou Paraskevi Xepapadaki Alexander Katoulis Michael Makris |
| author_facet | Niki Papapostolou Paraskevi Xepapadaki Alexander Katoulis Michael Makris |
| author_sort | Niki Papapostolou |
| collection | DOAJ |
| description | Chronic Urticaria (CU) is a chronic inflammatory, predominantly mast cell-driven disease, characterized by the development of wheals and/or angioedema for more than 6 weeks. It affects approximately 1%–5% of the total population worldwide and imposes a substantial burden on health-related quality of life, significantly affecting patients' daily life. The economic impact on the health system is also not negligible, with an estimated cost per patient per year of approximately 2.000 $ in the United States. Although the underlying pathophysiology is not fully explored, autoimmune mechanisms have been proposed, including type I (“autoallergy” by means of autoantibodies to self-antigens) and type IIb (autoimmunity). Atopic, autoimmune, and psychiatric disorders are prevalent comorbidities in both children and adults with Chronic Spontaneous Urticaria (CSU). Although malignancies, cardiovascular diseases and other comorbidities have also been reported as associated diseases in patients with CSU, data remain scarce. It is still unknown whether the aforementioned comorbidities share common pathophysiological mechanisms with specific endotypes of CSU. The current review aims to overview current data on comorbidities of CU, and furthermore to comment on the potential linked pathways underlying these diseases. |
| first_indexed | 2024-04-12T08:47:30Z |
| format | Article |
| id | doaj.art-89cff3cd1a5b4576a3de197bf246d706 |
| institution | Directory Open Access Journal |
| issn | 2673-6101 |
| language | English |
| last_indexed | 2024-04-12T08:47:30Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Allergy |
| spelling | doaj.art-89cff3cd1a5b4576a3de197bf246d7062022-12-22T03:39:40ZengFrontiers Media S.A.Frontiers in Allergy2673-61012022-11-01310.3389/falgy.2022.10081451008145Comorbidities of Chronic Urticaria: A glimpse into a complex relationshipNiki Papapostolou0Paraskevi Xepapadaki1Alexander Katoulis2Michael Makris3Allergy Unit, 2nd Department of Dermatology and Venereology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, GreeceAllergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, GreeceAllergy Unit, 2nd Department of Dermatology and Venereology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, GreeceAllergy Unit, 2nd Department of Dermatology and Venereology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, GreeceChronic Urticaria (CU) is a chronic inflammatory, predominantly mast cell-driven disease, characterized by the development of wheals and/or angioedema for more than 6 weeks. It affects approximately 1%–5% of the total population worldwide and imposes a substantial burden on health-related quality of life, significantly affecting patients' daily life. The economic impact on the health system is also not negligible, with an estimated cost per patient per year of approximately 2.000 $ in the United States. Although the underlying pathophysiology is not fully explored, autoimmune mechanisms have been proposed, including type I (“autoallergy” by means of autoantibodies to self-antigens) and type IIb (autoimmunity). Atopic, autoimmune, and psychiatric disorders are prevalent comorbidities in both children and adults with Chronic Spontaneous Urticaria (CSU). Although malignancies, cardiovascular diseases and other comorbidities have also been reported as associated diseases in patients with CSU, data remain scarce. It is still unknown whether the aforementioned comorbidities share common pathophysiological mechanisms with specific endotypes of CSU. The current review aims to overview current data on comorbidities of CU, and furthermore to comment on the potential linked pathways underlying these diseases.https://www.frontiersin.org/articles/10.3389/falgy.2022.1008145/fullchronic urticariacomorbiditieschronic spontaneous urticariapsychiatric disordersatopic diseasesautoimmune diseases |
| spellingShingle | Niki Papapostolou Paraskevi Xepapadaki Alexander Katoulis Michael Makris Comorbidities of Chronic Urticaria: A glimpse into a complex relationship Frontiers in Allergy chronic urticaria comorbidities chronic spontaneous urticaria psychiatric disorders atopic diseases autoimmune diseases |
| title | Comorbidities of Chronic Urticaria: A glimpse into a complex relationship |
| title_full | Comorbidities of Chronic Urticaria: A glimpse into a complex relationship |
| title_fullStr | Comorbidities of Chronic Urticaria: A glimpse into a complex relationship |
| title_full_unstemmed | Comorbidities of Chronic Urticaria: A glimpse into a complex relationship |
| title_short | Comorbidities of Chronic Urticaria: A glimpse into a complex relationship |
| title_sort | comorbidities of chronic urticaria a glimpse into a complex relationship |
| topic | chronic urticaria comorbidities chronic spontaneous urticaria psychiatric disorders atopic diseases autoimmune diseases |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2022.1008145/full |
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