Pathogenesis of fulminant type 1 diabetes: Genes, viruses and the immune mechanism, and usefulness of patient‐derived induced pluripotent stem cells for future research
Abstract We reviewed fulminant type 1 diabetes, a recently established subtype of type 1 diabetes, from the aspects of genes, viruses, immune mechanism and usefulness of patient‐derived induced pluripotent stem cells (iPSCs). In an analysis of the pancreas of patients with fulminant type 1 diabetes,...
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| Format: | Article |
| Language: | English |
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Wiley
2019-09-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13091 |
| _version_ | 1818613968626778112 |
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| author | Yoshiya Hosokawa Toshiaki Hanafusa Akihisa Imagawa |
| author_facet | Yoshiya Hosokawa Toshiaki Hanafusa Akihisa Imagawa |
| author_sort | Yoshiya Hosokawa |
| collection | DOAJ |
| description | Abstract We reviewed fulminant type 1 diabetes, a recently established subtype of type 1 diabetes, from the aspects of genes, viruses, immune mechanism and usefulness of patient‐derived induced pluripotent stem cells (iPSCs). In an analysis of the pancreas of patients with fulminant type 1 diabetes, viral antigens and viral receptors were expressed in β‐cells, as well as macrophages and T lymphocytes surrounding the β‐cells. These findings suggest that the β‐cells of patients with fulminant type 1 diabetes are destroyed during an immune response against viral infection of the pancreas. Recently, fulminant type 1 diabetes was induced by treatment with anti‐programmed cell death 1 antibodies, suggesting that immune regulatory mechanisms are also involved in the onset of this disease. We generated iPSCs from patients with fulminant type 1 diabetes for the first time. We also successfully differentiated patient‐derived iPSCs into insulin‐producing cells in vitro, and produced a disease model. The proportion of cytokine‐induced apoptotic cells among insulin‐positive cells was higher in the iPSCs from patients with fulminant type 1 diabetes than in iPSCs from healthy control participants. We carried out ribonucleic acid sequencing in insulin‐producing cells differentiated from patient‐derived iPSCs, and are now attempting to identify new biomarkers for the disease. |
| first_indexed | 2024-12-16T16:10:33Z |
| format | Article |
| id | doaj.art-89d015726adf4ecb99b099ecb2d5c3ae |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-12-16T16:10:33Z |
| publishDate | 2019-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-89d015726adf4ecb99b099ecb2d5c3ae2022-12-21T22:25:15ZengWileyJournal of Diabetes Investigation2040-11162040-11242019-09-011051158116410.1111/jdi.13091Pathogenesis of fulminant type 1 diabetes: Genes, viruses and the immune mechanism, and usefulness of patient‐derived induced pluripotent stem cells for future researchYoshiya Hosokawa0Toshiaki Hanafusa1Akihisa Imagawa2Department of Metabolic Medicine Osaka University Graduate School of Medicine Suita JapanSakai City Medical Center Sakai JapanDepartment of Internal Medicine (I) Osaka Medical College Takatsuki JapanAbstract We reviewed fulminant type 1 diabetes, a recently established subtype of type 1 diabetes, from the aspects of genes, viruses, immune mechanism and usefulness of patient‐derived induced pluripotent stem cells (iPSCs). In an analysis of the pancreas of patients with fulminant type 1 diabetes, viral antigens and viral receptors were expressed in β‐cells, as well as macrophages and T lymphocytes surrounding the β‐cells. These findings suggest that the β‐cells of patients with fulminant type 1 diabetes are destroyed during an immune response against viral infection of the pancreas. Recently, fulminant type 1 diabetes was induced by treatment with anti‐programmed cell death 1 antibodies, suggesting that immune regulatory mechanisms are also involved in the onset of this disease. We generated iPSCs from patients with fulminant type 1 diabetes for the first time. We also successfully differentiated patient‐derived iPSCs into insulin‐producing cells in vitro, and produced a disease model. The proportion of cytokine‐induced apoptotic cells among insulin‐positive cells was higher in the iPSCs from patients with fulminant type 1 diabetes than in iPSCs from healthy control participants. We carried out ribonucleic acid sequencing in insulin‐producing cells differentiated from patient‐derived iPSCs, and are now attempting to identify new biomarkers for the disease.https://doi.org/10.1111/jdi.13091Fulminant type 1 diabetesImmune‐check point inhibitorInduced pluripotent stem cells |
| spellingShingle | Yoshiya Hosokawa Toshiaki Hanafusa Akihisa Imagawa Pathogenesis of fulminant type 1 diabetes: Genes, viruses and the immune mechanism, and usefulness of patient‐derived induced pluripotent stem cells for future research Journal of Diabetes Investigation Fulminant type 1 diabetes Immune‐check point inhibitor Induced pluripotent stem cells |
| title | Pathogenesis of fulminant type 1 diabetes: Genes, viruses and the immune mechanism, and usefulness of patient‐derived induced pluripotent stem cells for future research |
| title_full | Pathogenesis of fulminant type 1 diabetes: Genes, viruses and the immune mechanism, and usefulness of patient‐derived induced pluripotent stem cells for future research |
| title_fullStr | Pathogenesis of fulminant type 1 diabetes: Genes, viruses and the immune mechanism, and usefulness of patient‐derived induced pluripotent stem cells for future research |
| title_full_unstemmed | Pathogenesis of fulminant type 1 diabetes: Genes, viruses and the immune mechanism, and usefulness of patient‐derived induced pluripotent stem cells for future research |
| title_short | Pathogenesis of fulminant type 1 diabetes: Genes, viruses and the immune mechanism, and usefulness of patient‐derived induced pluripotent stem cells for future research |
| title_sort | pathogenesis of fulminant type 1 diabetes genes viruses and the immune mechanism and usefulness of patient derived induced pluripotent stem cells for future research |
| topic | Fulminant type 1 diabetes Immune‐check point inhibitor Induced pluripotent stem cells |
| url | https://doi.org/10.1111/jdi.13091 |
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