Insertion/deletion polymorphism of ACE gene in females with peripartum cardiomyopathy: A case-control study
Background: The role of polymorphism of Angiotensin converting enzyme (ACE) gene and ACE activity in etiopathogenesis, prognosis, and many other clinical parameters in the various form of the cardiovascular disease has been established to some degree of certainty. The pathophysiology of Peripartum c...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Indian Heart Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0019483216301687 |
| _version_ | 1819173284182228992 |
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| author | Irfan Yaqoob Nisar A. Tramboo Irfan A. Bhat Arshad Pandith Jahangir R. Beig Imran Hafeez Aijaz A. Lone Tariq R. Shah Sumera Samreen |
| author_facet | Irfan Yaqoob Nisar A. Tramboo Irfan A. Bhat Arshad Pandith Jahangir R. Beig Imran Hafeez Aijaz A. Lone Tariq R. Shah Sumera Samreen |
| author_sort | Irfan Yaqoob |
| collection | DOAJ |
| description | Background: The role of polymorphism of Angiotensin converting enzyme (ACE) gene and ACE activity in etiopathogenesis, prognosis, and many other clinical parameters in the various form of the cardiovascular disease has been established to some degree of certainty. The pathophysiology of Peripartum cardiomyopathy (PPCM) remains an area of active research. The main aim of our study was to see pattern of ACE- Insertion/Deletion (I/D) allele in PPCM and its implications on left ventricular performance indices.
Methods: This single-center case-control study included 45 cases and 70 controls. The diagnosis of PPCM was established clinically and echocardiographically. ACE genotyping was done by polymerase chain reaction (PCR) method in all subjects.
Results: The II, ID, and DD genotype was present in 16, 18 and 11 of subjects with PPCM and 48, 19 and 3 of controls respectively. The odds ratio for ACE-II genotype in cases vs. controls was 0.253 (95% CI = 0.114–0.558; p = 0.007), for that of II genotype was 1.93 (95% CI = 0.86–4.3; p = 0.107) and for DD genotype was 7.225 (95% CI; 1.88–27.6; p = 0.0039). Overall frequency of D allele in cases was significantly higher than controls (odds = 4.25; 95% CI = 2.01–6.7; p = 0.0001). Moreover, ejection fraction, left ventricular volume and linear dimensions were worse in patients with DD genotype.
Conclusion: ACE DD genotype and overall frequency of D allele is significantly higher in patients with PPCM. Also, the presence of DD genotype is associated with worse systolic performance indices measured echocardiographically. |
| first_indexed | 2024-12-22T20:20:38Z |
| format | Article |
| id | doaj.art-89d09228cff646f4bb6d5165f76c1031 |
| institution | Directory Open Access Journal |
| issn | 0019-4832 |
| language | English |
| last_indexed | 2024-12-22T20:20:38Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Indian Heart Journal |
| spelling | doaj.art-89d09228cff646f4bb6d5165f76c10312022-12-21T18:13:51ZengElsevierIndian Heart Journal0019-48322018-01-01701667010.1016/j.ihj.2017.05.020Insertion/deletion polymorphism of ACE gene in females with peripartum cardiomyopathy: A case-control studyIrfan Yaqoob0Nisar A. Tramboo1Irfan A. Bhat2Arshad Pandith3Jahangir R. Beig4Imran Hafeez5Aijaz A. Lone6Tariq R. Shah7Sumera Samreen8Dep’t. of Cardiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, IndiaDep’t. of Cardiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, IndiaDep’t. of Cardiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, IndiaDep’t. Of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, IndiaDep’t. of Cardiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, IndiaDep’t. of Cardiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, IndiaDep’t. of Cardiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, IndiaDep’t. of Cardiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, IndiaDep’t. of Cardiology, Government Medical College, Srinagar, IndiaBackground: The role of polymorphism of Angiotensin converting enzyme (ACE) gene and ACE activity in etiopathogenesis, prognosis, and many other clinical parameters in the various form of the cardiovascular disease has been established to some degree of certainty. The pathophysiology of Peripartum cardiomyopathy (PPCM) remains an area of active research. The main aim of our study was to see pattern of ACE- Insertion/Deletion (I/D) allele in PPCM and its implications on left ventricular performance indices. Methods: This single-center case-control study included 45 cases and 70 controls. The diagnosis of PPCM was established clinically and echocardiographically. ACE genotyping was done by polymerase chain reaction (PCR) method in all subjects. Results: The II, ID, and DD genotype was present in 16, 18 and 11 of subjects with PPCM and 48, 19 and 3 of controls respectively. The odds ratio for ACE-II genotype in cases vs. controls was 0.253 (95% CI = 0.114–0.558; p = 0.007), for that of II genotype was 1.93 (95% CI = 0.86–4.3; p = 0.107) and for DD genotype was 7.225 (95% CI; 1.88–27.6; p = 0.0039). Overall frequency of D allele in cases was significantly higher than controls (odds = 4.25; 95% CI = 2.01–6.7; p = 0.0001). Moreover, ejection fraction, left ventricular volume and linear dimensions were worse in patients with DD genotype. Conclusion: ACE DD genotype and overall frequency of D allele is significantly higher in patients with PPCM. Also, the presence of DD genotype is associated with worse systolic performance indices measured echocardiographically.http://www.sciencedirect.com/science/article/pii/S0019483216301687Peripartum cardiomyopathyHeart failureAngiotensin converting enzyme geneEchocardiography |
| spellingShingle | Irfan Yaqoob Nisar A. Tramboo Irfan A. Bhat Arshad Pandith Jahangir R. Beig Imran Hafeez Aijaz A. Lone Tariq R. Shah Sumera Samreen Insertion/deletion polymorphism of ACE gene in females with peripartum cardiomyopathy: A case-control study Indian Heart Journal Peripartum cardiomyopathy Heart failure Angiotensin converting enzyme gene Echocardiography |
| title | Insertion/deletion polymorphism of ACE gene in females with peripartum cardiomyopathy: A case-control study |
| title_full | Insertion/deletion polymorphism of ACE gene in females with peripartum cardiomyopathy: A case-control study |
| title_fullStr | Insertion/deletion polymorphism of ACE gene in females with peripartum cardiomyopathy: A case-control study |
| title_full_unstemmed | Insertion/deletion polymorphism of ACE gene in females with peripartum cardiomyopathy: A case-control study |
| title_short | Insertion/deletion polymorphism of ACE gene in females with peripartum cardiomyopathy: A case-control study |
| title_sort | insertion deletion polymorphism of ace gene in females with peripartum cardiomyopathy a case control study |
| topic | Peripartum cardiomyopathy Heart failure Angiotensin converting enzyme gene Echocardiography |
| url | http://www.sciencedirect.com/science/article/pii/S0019483216301687 |
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