Dietary supplementation with a specific melon concentrate reverses vascular dysfunction induced by cafeteria diet
Background: Obesity-related metabolic syndrome is associated with high incidence of cardiovascular diseases partially consecutive to vascular dysfunction. Therapeutic strategies consisting of multidisciplinary interventions include nutritional approaches. Benefits of supplementation with a specific...
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| Format: | Article |
| Language: | English |
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Swedish Nutrition Foundation
2016-11-01
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| Series: | Food & Nutrition Research |
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| Online Access: | http://www.foodandnutritionresearch.net/index.php/fnr/article/view/32729/49703 |
| _version_ | 1819129408125927424 |
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| author | Julie Carillon Bernard Jover Jean-Paul Cristol Jean-Max Rouanet Sylvain Richard Anne Virsolvy |
| author_facet | Julie Carillon Bernard Jover Jean-Paul Cristol Jean-Max Rouanet Sylvain Richard Anne Virsolvy |
| author_sort | Julie Carillon |
| collection | DOAJ |
| description | Background: Obesity-related metabolic syndrome is associated with high incidence of cardiovascular diseases partially consecutive to vascular dysfunction. Therapeutic strategies consisting of multidisciplinary interventions include nutritional approaches. Benefits of supplementation with a specific melon concentrate, enriched in superoxide dismutase (SOD), have previously been shown on the development of insulin resistance and inflammation in a nutritional hamster model of obesity. Objective: We further investigated arterial function in this animal model of metabolic syndrome and studied the effect of melon concentrate supplementation on arterial contractile activity. Design and results: The study was performed on a hamster model of diet-induced obesity. After a 15-week period of cafeteria diet, animals were supplemented during 4 weeks with a specific melon concentrate (Cucumis melo L.) Contractile responses of isolated aorta to various agonists and antagonists were studied ex vivo. Cafeteria diet induced vascular contractile dysfunction associated with morphological remodeling. Melon concentrate supplementation partially corrected these dysfunctions; reduced morphological alterations; and improved contractile function, especially by increasing nitric oxide bioavailability and expression of endogenous SOD. Conclusions: Supplementation with the specific melon concentrate improves vascular dysfunction associated with obesity. This beneficial effect may be accounted for by induction of endogenous antioxidant defense. Such an approach in line with nutritional interventions could be a useful strategy to manage metabolic syndrome–induced cardiovascular trouble. |
| first_indexed | 2024-12-22T08:43:14Z |
| format | Article |
| id | doaj.art-89d12055d13d4206af8b3ae2ade5535d |
| institution | Directory Open Access Journal |
| issn | 1654-661X |
| language | English |
| last_indexed | 2024-12-22T08:43:14Z |
| publishDate | 2016-11-01 |
| publisher | Swedish Nutrition Foundation |
| record_format | Article |
| series | Food & Nutrition Research |
| spelling | doaj.art-89d12055d13d4206af8b3ae2ade5535d2022-12-21T18:32:11ZengSwedish Nutrition FoundationFood & Nutrition Research1654-661X2016-11-016001910.3402/fnr.v60.3272932729Dietary supplementation with a specific melon concentrate reverses vascular dysfunction induced by cafeteria dietJulie Carillon0Bernard Jover1Jean-Paul Cristol2Jean-Max Rouanet3Sylvain Richard4Anne Virsolvy5 Nutrition & Metabolism, UMR 204 NutriPass, University of Montpellier, Montpellier, France EA7288, University of Montpellier, Montpellier, France PhyMedExp, INSERM U1046, UMR CNRS 9214, University of Montpellier, Montpellier, France Nutrition & Metabolism, UMR 204 NutriPass, University of Montpellier, Montpellier, France PhyMedExp, INSERM U1046, UMR CNRS 9214, University of Montpellier, Montpellier, France PhyMedExp, INSERM U1046, UMR CNRS 9214, University of Montpellier, Montpellier, FranceBackground: Obesity-related metabolic syndrome is associated with high incidence of cardiovascular diseases partially consecutive to vascular dysfunction. Therapeutic strategies consisting of multidisciplinary interventions include nutritional approaches. Benefits of supplementation with a specific melon concentrate, enriched in superoxide dismutase (SOD), have previously been shown on the development of insulin resistance and inflammation in a nutritional hamster model of obesity. Objective: We further investigated arterial function in this animal model of metabolic syndrome and studied the effect of melon concentrate supplementation on arterial contractile activity. Design and results: The study was performed on a hamster model of diet-induced obesity. After a 15-week period of cafeteria diet, animals were supplemented during 4 weeks with a specific melon concentrate (Cucumis melo L.) Contractile responses of isolated aorta to various agonists and antagonists were studied ex vivo. Cafeteria diet induced vascular contractile dysfunction associated with morphological remodeling. Melon concentrate supplementation partially corrected these dysfunctions; reduced morphological alterations; and improved contractile function, especially by increasing nitric oxide bioavailability and expression of endogenous SOD. Conclusions: Supplementation with the specific melon concentrate improves vascular dysfunction associated with obesity. This beneficial effect may be accounted for by induction of endogenous antioxidant defense. Such an approach in line with nutritional interventions could be a useful strategy to manage metabolic syndrome–induced cardiovascular trouble.http://www.foodandnutritionresearch.net/index.php/fnr/article/view/32729/49703vascular functionoxidative stressantioxidantsuperoxide dismutaseobesity |
| spellingShingle | Julie Carillon Bernard Jover Jean-Paul Cristol Jean-Max Rouanet Sylvain Richard Anne Virsolvy Dietary supplementation with a specific melon concentrate reverses vascular dysfunction induced by cafeteria diet Food & Nutrition Research vascular function oxidative stress antioxidant superoxide dismutase obesity |
| title | Dietary supplementation with a specific melon concentrate reverses vascular dysfunction induced by cafeteria diet |
| title_full | Dietary supplementation with a specific melon concentrate reverses vascular dysfunction induced by cafeteria diet |
| title_fullStr | Dietary supplementation with a specific melon concentrate reverses vascular dysfunction induced by cafeteria diet |
| title_full_unstemmed | Dietary supplementation with a specific melon concentrate reverses vascular dysfunction induced by cafeteria diet |
| title_short | Dietary supplementation with a specific melon concentrate reverses vascular dysfunction induced by cafeteria diet |
| title_sort | dietary supplementation with a specific melon concentrate reverses vascular dysfunction induced by cafeteria diet |
| topic | vascular function oxidative stress antioxidant superoxide dismutase obesity |
| url | http://www.foodandnutritionresearch.net/index.php/fnr/article/view/32729/49703 |
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