Culturally adapted psychosocial interventions (CaPSI) for early psychosis in a low-resource setting: study protocol for a large multi-center RCT
Abstract Background Psychosis treatment guidelines recommend cognitive behaviour therapy (CBT) and family intervention (FI), for all patients with first episode psychosis (FEP), though guidance borrows heavily from literature in adults from high income countries. To our knowledge, there are few rand...
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BMC
2023-06-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-023-04904-8 |
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| author | M. O. Husain A. B. Khoso T. Kiran N. Chaudhry M. I. Husain M. Asif M. Ansari A. H. Rajput S. Dawood H. A. Naqvi A. T. Nizami Z. Tareen J. Rumi S. Sherzad H. A. Khan M. R. Bhatia K. M. S. Siddiqui Z. Zadeh N. Mehmood U. Talib C. de Oliveira F. Naeem W. Wang A. Voineskos N. Husain G. Foussias I. B. Chaudhry |
| author_facet | M. O. Husain A. B. Khoso T. Kiran N. Chaudhry M. I. Husain M. Asif M. Ansari A. H. Rajput S. Dawood H. A. Naqvi A. T. Nizami Z. Tareen J. Rumi S. Sherzad H. A. Khan M. R. Bhatia K. M. S. Siddiqui Z. Zadeh N. Mehmood U. Talib C. de Oliveira F. Naeem W. Wang A. Voineskos N. Husain G. Foussias I. B. Chaudhry |
| author_sort | M. O. Husain |
| collection | DOAJ |
| description | Abstract Background Psychosis treatment guidelines recommend cognitive behaviour therapy (CBT) and family intervention (FI), for all patients with first episode psychosis (FEP), though guidance borrows heavily from literature in adults from high income countries. To our knowledge, there are few randomized controlled trials (RCTs) examining the comparative effect of these commonly endorsed psychosocial interventions in individuals with early psychosis from high-income countries and no such trials from low and middle-income countries (LMICs). The present study aims to confirm the clinical-efficacy and cost-effectiveness of delivering culturally adapted CBT (CaCBT) and culturally adapted FI (CulFI) to individuals with FEP in Pakistan. Method A multi-centre, three-arm RCT of CaCBT, CulFI, and treatment as usual (TAU) for individuals with FEP (n = 390), recruited from major centres across Pakistan. Reducing overall symptoms of FEP will be the primary outcome. Additional aims will include improving patient and carer outcomes and estimating the economic impact of delivering culturally appropriate psychosocial interventions in low-resource settings. This trial will assess the clinical-efficacy and cost-effectiveness of CaCBT and CulFI compared with TAU in improving patient (positive and negative symptoms of psychosis, general psychopathology, depressive symptoms, quality of life, cognition, general functioning, and insight) and carer related outcomes (carer experience, wellbeing, illness attitudes and symptoms of depression and anxiety). Conclusions A successful trial may inform the rapid scale up of these interventions not only in Pakistan but other low-resource settings, to improve clinical outcomes, social and occupational functioning, and quality of life in South Asian and other minority groups with FEP. Trial registration NCT05814913. |
| first_indexed | 2024-03-13T04:48:34Z |
| format | Article |
| id | doaj.art-89d4d51e72ba4106a11f124a4713b8a8 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-03-13T04:48:34Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
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| series | BMC Psychiatry |
| spelling | doaj.art-89d4d51e72ba4106a11f124a4713b8a82023-06-18T11:21:35ZengBMCBMC Psychiatry1471-244X2023-06-012311910.1186/s12888-023-04904-8Culturally adapted psychosocial interventions (CaPSI) for early psychosis in a low-resource setting: study protocol for a large multi-center RCTM. O. Husain0A. B. Khoso1T. Kiran2N. Chaudhry3M. I. Husain4M. Asif5M. Ansari6A. H. Rajput7S. Dawood8H. A. Naqvi9A. T. Nizami10Z. Tareen11J. Rumi12S. Sherzad13H. A. Khan14M. R. Bhatia15K. M. S. Siddiqui16Z. Zadeh17N. Mehmood18U. Talib19C. de Oliveira20F. Naeem21W. Wang22A. Voineskos23N. Husain24G. Foussias25I. B. Chaudhry26Campbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthPakistan Institute of Living and LearningPakistan Institute of Living and LearningPakistan Institute of Living and LearningCampbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthPakistan Institute of Living and LearningDepartment of Psychiatry, Liaquat University of Medical and Health SciencesDepartment of Psychiatry, Liaquat University of Medical and Health SciencesCentre for Clinical Psychology, University of the PunjabDepartment of Psychiatry, Dow University Health SciencesInstitute of Psychiatry, Benazir Bhutto HospitalDepartment of Psychiatry, Balochistan Institute of Psychiatry & Behavioural SciencesDepartment of Psychiatry, Balochistan Institute of Psychiatry & Behavioural SciencesDepartment of Psychiatry, Balochistan Institute of Psychiatry & Behavioural SciencesDepartment of Psychiatry, Balochistan Institute of Psychiatry & Behavioural SciencesDepartment of Psychiatry, Peoples University of Medical and Health SciencesNational Psychiatric HospitalPakistan Institute of Living and LearningInstitute for Mental Health, Karwan-E-HayatInstitute for Mental Health, Karwan-E-HayatCampbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthCampbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthCampbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthCampbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthMersey Care NHS Foundation TrustCampbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthPakistan Institute of Living and LearningAbstract Background Psychosis treatment guidelines recommend cognitive behaviour therapy (CBT) and family intervention (FI), for all patients with first episode psychosis (FEP), though guidance borrows heavily from literature in adults from high income countries. To our knowledge, there are few randomized controlled trials (RCTs) examining the comparative effect of these commonly endorsed psychosocial interventions in individuals with early psychosis from high-income countries and no such trials from low and middle-income countries (LMICs). The present study aims to confirm the clinical-efficacy and cost-effectiveness of delivering culturally adapted CBT (CaCBT) and culturally adapted FI (CulFI) to individuals with FEP in Pakistan. Method A multi-centre, three-arm RCT of CaCBT, CulFI, and treatment as usual (TAU) for individuals with FEP (n = 390), recruited from major centres across Pakistan. Reducing overall symptoms of FEP will be the primary outcome. Additional aims will include improving patient and carer outcomes and estimating the economic impact of delivering culturally appropriate psychosocial interventions in low-resource settings. This trial will assess the clinical-efficacy and cost-effectiveness of CaCBT and CulFI compared with TAU in improving patient (positive and negative symptoms of psychosis, general psychopathology, depressive symptoms, quality of life, cognition, general functioning, and insight) and carer related outcomes (carer experience, wellbeing, illness attitudes and symptoms of depression and anxiety). Conclusions A successful trial may inform the rapid scale up of these interventions not only in Pakistan but other low-resource settings, to improve clinical outcomes, social and occupational functioning, and quality of life in South Asian and other minority groups with FEP. Trial registration NCT05814913.https://doi.org/10.1186/s12888-023-04904-8Early psychosisPsychosocial interventionsRandomized control trialPakistan |
| spellingShingle | M. O. Husain A. B. Khoso T. Kiran N. Chaudhry M. I. Husain M. Asif M. Ansari A. H. Rajput S. Dawood H. A. Naqvi A. T. Nizami Z. Tareen J. Rumi S. Sherzad H. A. Khan M. R. Bhatia K. M. S. Siddiqui Z. Zadeh N. Mehmood U. Talib C. de Oliveira F. Naeem W. Wang A. Voineskos N. Husain G. Foussias I. B. Chaudhry Culturally adapted psychosocial interventions (CaPSI) for early psychosis in a low-resource setting: study protocol for a large multi-center RCT BMC Psychiatry Early psychosis Psychosocial interventions Randomized control trial Pakistan |
| title | Culturally adapted psychosocial interventions (CaPSI) for early psychosis in a low-resource setting: study protocol for a large multi-center RCT |
| title_full | Culturally adapted psychosocial interventions (CaPSI) for early psychosis in a low-resource setting: study protocol for a large multi-center RCT |
| title_fullStr | Culturally adapted psychosocial interventions (CaPSI) for early psychosis in a low-resource setting: study protocol for a large multi-center RCT |
| title_full_unstemmed | Culturally adapted psychosocial interventions (CaPSI) for early psychosis in a low-resource setting: study protocol for a large multi-center RCT |
| title_short | Culturally adapted psychosocial interventions (CaPSI) for early psychosis in a low-resource setting: study protocol for a large multi-center RCT |
| title_sort | culturally adapted psychosocial interventions capsi for early psychosis in a low resource setting study protocol for a large multi center rct |
| topic | Early psychosis Psychosocial interventions Randomized control trial Pakistan |
| url | https://doi.org/10.1186/s12888-023-04904-8 |
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