P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease

P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease

Abstract The transcription factor, p53, is critical for many important cellular functions involved in genome integrity, including cell cycle control, DNA damage response, and apoptosis. Disruption of p53 results in a wide range of disorders including cancer, metabolic diseases, and neurodegenerative...

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Bibliographic Details
Main Authors: Kathleen M. Farmer, Gaurav Ghag, Nicha Puangmalai, Mauro Montalbano, Nemil Bhatt, Rakez Kayed
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Acta Neuropathologica Communications
Subjects:
p53
Tau
Oligomers
DNA damage
Seeding
Cross-seeding
Online Access:http://link.springer.com/article/10.1186/s40478-020-01012-6

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