Serotonin signals through a gut-liver axis to regulate hepatic steatosis
No effective pharmacological treatments exist for nonalcoholic fatty liver disease (NAFLD). Here, the authors show that serotonin concentration in the portal blood is increased in nine human subjects and in mice fed a high-fat diet, and that local serotonin signaling ablation, either genetically or...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07287-7 |
| _version_ | 1831827867049132032 |
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| author | Wonsuk Choi Jun Namkung Inseon Hwang Hyeongseok Kim Ajin Lim Hye Jung Park Hye Won Lee Kwang-Hyub Han Seongyeol Park Ji-Seon Jeong Geul Bang Young Hwan Kim Vijay K. Yadav Gerard Karsenty Young Seok Ju Chan Choi Jae Myoung Suh Jun Yong Park Sangkyu Park Hail Kim |
| author_facet | Wonsuk Choi Jun Namkung Inseon Hwang Hyeongseok Kim Ajin Lim Hye Jung Park Hye Won Lee Kwang-Hyub Han Seongyeol Park Ji-Seon Jeong Geul Bang Young Hwan Kim Vijay K. Yadav Gerard Karsenty Young Seok Ju Chan Choi Jae Myoung Suh Jun Yong Park Sangkyu Park Hail Kim |
| author_sort | Wonsuk Choi |
| collection | DOAJ |
| description | No effective pharmacological treatments exist for nonalcoholic fatty liver disease (NAFLD). Here, the authors show that serotonin concentration in the portal blood is increased in nine human subjects and in mice fed a high-fat diet, and that local serotonin signaling ablation, either genetically or with an antagonist, prevents hepatic steatosis in mice. |
| first_indexed | 2024-12-23T02:08:59Z |
| format | Article |
| id | doaj.art-89d5af7961f4435c8b79cd484b17891a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:08:59Z |
| publishDate | 2018-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-89d5af7961f4435c8b79cd484b17891a2022-12-21T18:03:49ZengNature PortfolioNature Communications2041-17232018-11-01911910.1038/s41467-018-07287-7Serotonin signals through a gut-liver axis to regulate hepatic steatosisWonsuk Choi0Jun Namkung1Inseon Hwang2Hyeongseok Kim3Ajin Lim4Hye Jung Park5Hye Won Lee6Kwang-Hyub Han7Seongyeol Park8Ji-Seon Jeong9Geul Bang10Young Hwan Kim11Vijay K. Yadav12Gerard Karsenty13Young Seok Ju14Chan Choi15Jae Myoung Suh16Jun Yong Park17Sangkyu Park18Hail Kim19Graduate School of Medical Science and Engineering, KAISTGraduate School of Medical Science and Engineering, KAISTBiomedical Science and Engineering Interdisciplinary Program, KAISTGraduate School of Medical Science and Engineering, KAISTGraduate School of Medical Science and Engineering, KAISTDepartment of Internal Medicine, Yonsei University College of Medicine, Yonsei Liver Center, Severance HospitalDepartment of Internal Medicine, Yonsei University College of Medicine, Yonsei Liver Center, Severance HospitalDepartment of Internal Medicine, Yonsei University College of Medicine, Yonsei Liver Center, Severance HospitalGraduate School of Medical Science and Engineering, KAISTCenter for Bioanalysis, Division of Metrology for Quality of Life, Korea Research Institute of Standards and ScienceBiomedical Omics Group, Korea Basic Science InstituteBiomedical Omics Group, Korea Basic Science InstituteDepartment of Genetics and Development, Columbia University Medical CenterDepartment of Genetics and Development, Columbia University Medical CenterGraduate School of Medical Science and Engineering, KAISTDepartment of Pathology, Chonnam National University Medical SchoolGraduate School of Medical Science and Engineering, KAISTDepartment of Internal Medicine, Yonsei University College of Medicine, Yonsei Liver Center, Severance HospitalGraduate School of Medical Science and Engineering, KAISTGraduate School of Medical Science and Engineering, KAISTNo effective pharmacological treatments exist for nonalcoholic fatty liver disease (NAFLD). Here, the authors show that serotonin concentration in the portal blood is increased in nine human subjects and in mice fed a high-fat diet, and that local serotonin signaling ablation, either genetically or with an antagonist, prevents hepatic steatosis in mice.https://doi.org/10.1038/s41467-018-07287-7 |
| spellingShingle | Wonsuk Choi Jun Namkung Inseon Hwang Hyeongseok Kim Ajin Lim Hye Jung Park Hye Won Lee Kwang-Hyub Han Seongyeol Park Ji-Seon Jeong Geul Bang Young Hwan Kim Vijay K. Yadav Gerard Karsenty Young Seok Ju Chan Choi Jae Myoung Suh Jun Yong Park Sangkyu Park Hail Kim Serotonin signals through a gut-liver axis to regulate hepatic steatosis Nature Communications |
| title | Serotonin signals through a gut-liver axis to regulate hepatic steatosis |
| title_full | Serotonin signals through a gut-liver axis to regulate hepatic steatosis |
| title_fullStr | Serotonin signals through a gut-liver axis to regulate hepatic steatosis |
| title_full_unstemmed | Serotonin signals through a gut-liver axis to regulate hepatic steatosis |
| title_short | Serotonin signals through a gut-liver axis to regulate hepatic steatosis |
| title_sort | serotonin signals through a gut liver axis to regulate hepatic steatosis |
| url | https://doi.org/10.1038/s41467-018-07287-7 |
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