Radiation-induced eosinophil increase ratio predicts patient outcomes in non-small celllung cancer
Background and purposeRadiotherapy (RT) is a double-edged sword in regulating immune responses. This study aimed to investigate the impact of thoracic RT on circulating eosinophils and its association with patient outcomes in non-small cell lung cancer (NSCLC).Materials and methodsThis retrospective...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.999555/full |
| _version_ | 1797996428384010240 |
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| author | Nuo-Han Wang Xin Zhang Jiang-Dong Sui Ying Wang Yong-Zhong Wu Qian-Qian Lei Hong-Lei Tu Li-Na Yang Yun-Chang Liu Meng-Qi Yang Hao-Nan Yang Dan Li Zheng Lei |
| author_facet | Nuo-Han Wang Xin Zhang Jiang-Dong Sui Ying Wang Yong-Zhong Wu Qian-Qian Lei Hong-Lei Tu Li-Na Yang Yun-Chang Liu Meng-Qi Yang Hao-Nan Yang Dan Li Zheng Lei |
| author_sort | Nuo-Han Wang |
| collection | DOAJ |
| description | Background and purposeRadiotherapy (RT) is a double-edged sword in regulating immune responses. This study aimed to investigate the impact of thoracic RT on circulating eosinophils and its association with patient outcomes in non-small cell lung cancer (NSCLC).Materials and methodsThis retrospective study included 240 patients with advanced NSCLC treated with definitive thoracic RT from January 2012 to January 2020. Statistics included Kaplan-Meier analysis of overall survival (OS) and progression-free survival (PFS), multivariate Cox analyses to identify significant variables, and Spearman’s correlation to qualify the relationship between dose-volume histogram (DVH) parameters and EIR.ResultsAbsolute eosinophil counts (AECs) showed an increasing trend during RT and an obvious peak in the 1st month after RT. Thresholds of eosinophil increase ratio (EIR) at the 1st month after RT for both OS and PFS were 1.43. Patients with high EIR above 1.43 experienced particularly favorable clinical outcomes (five-year OS: 21% versus 10%, P<0.0001; five-year PFS: 10% versus 8%, P=0.014), but may not derive PFS benefit from the addition of chemotherapy to RT. The higher a patient’s EIR, the larger the potential benefit in the absence of chemotherapy. DVH parameters including heart mean dose and heart V10 were negatively associated with EIR. None of these DVH parameters was correlated with the clinical outcomes.ConclusionEIR may serve as a potential biomarker to predict OS and PFS in NSCLC patients treated with RT. These findings require prospective studies to evaluate the role of such prognostic marker to identify patients at risk to tailor interventions. |
| first_indexed | 2024-04-11T10:17:22Z |
| format | Article |
| id | doaj.art-89d73c541b994550948d49cd1e8106b4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T10:17:22Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-89d73c541b994550948d49cd1e8106b42022-12-22T04:29:55ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.999555999555Radiation-induced eosinophil increase ratio predicts patient outcomes in non-small celllung cancerNuo-Han Wang0Xin Zhang1Jiang-Dong Sui2Ying Wang3Yong-Zhong Wu4Qian-Qian Lei5Hong-Lei Tu6Li-Na Yang7Yun-Chang Liu8Meng-Qi Yang9Hao-Nan Yang10Dan Li11Zheng Lei12College of Medicine, Chongqing University, Chongqing, ChinaRadiation Oncology Center, Chongqing University Cancer Hospital, Chongqing, ChinaRadiation Oncology Center, Chongqing University Cancer Hospital, Chongqing, ChinaRadiation Oncology Center, Chongqing University Cancer Hospital, Chongqing, ChinaRadiation Oncology Center, Chongqing University Cancer Hospital, Chongqing, ChinaRadiation Oncology Center, Chongqing University Cancer Hospital, Chongqing, ChinaRadiation Oncology Center, Chongqing University Cancer Hospital, Chongqing, ChinaRadiation Oncology Center, Chongqing University Cancer Hospital, Chongqing, ChinaCollege of Bioengineering, Chongqing University, Chongqing, ChinaRadiation Oncology Center, Chongqing University Cancer Hospital, Chongqing, ChinaCollege of Bioengineering, Chongqing University, Chongqing, ChinaCollege of Medicine, Chongqing University, Chongqing, ChinaCollege of Medicine, Chongqing University, Chongqing, ChinaBackground and purposeRadiotherapy (RT) is a double-edged sword in regulating immune responses. This study aimed to investigate the impact of thoracic RT on circulating eosinophils and its association with patient outcomes in non-small cell lung cancer (NSCLC).Materials and methodsThis retrospective study included 240 patients with advanced NSCLC treated with definitive thoracic RT from January 2012 to January 2020. Statistics included Kaplan-Meier analysis of overall survival (OS) and progression-free survival (PFS), multivariate Cox analyses to identify significant variables, and Spearman’s correlation to qualify the relationship between dose-volume histogram (DVH) parameters and EIR.ResultsAbsolute eosinophil counts (AECs) showed an increasing trend during RT and an obvious peak in the 1st month after RT. Thresholds of eosinophil increase ratio (EIR) at the 1st month after RT for both OS and PFS were 1.43. Patients with high EIR above 1.43 experienced particularly favorable clinical outcomes (five-year OS: 21% versus 10%, P<0.0001; five-year PFS: 10% versus 8%, P=0.014), but may not derive PFS benefit from the addition of chemotherapy to RT. The higher a patient’s EIR, the larger the potential benefit in the absence of chemotherapy. DVH parameters including heart mean dose and heart V10 were negatively associated with EIR. None of these DVH parameters was correlated with the clinical outcomes.ConclusionEIR may serve as a potential biomarker to predict OS and PFS in NSCLC patients treated with RT. These findings require prospective studies to evaluate the role of such prognostic marker to identify patients at risk to tailor interventions.https://www.frontiersin.org/articles/10.3389/fonc.2022.999555/fullradiotherapydose-volume histogram parameterseosinophil increase rationon-small cell lung cancerSequential chemoradiotherapy |
| spellingShingle | Nuo-Han Wang Xin Zhang Jiang-Dong Sui Ying Wang Yong-Zhong Wu Qian-Qian Lei Hong-Lei Tu Li-Na Yang Yun-Chang Liu Meng-Qi Yang Hao-Nan Yang Dan Li Zheng Lei Radiation-induced eosinophil increase ratio predicts patient outcomes in non-small celllung cancer Frontiers in Oncology radiotherapy dose-volume histogram parameters eosinophil increase ratio non-small cell lung cancer Sequential chemoradiotherapy |
| title | Radiation-induced eosinophil increase ratio predicts patient outcomes in non-small celllung cancer |
| title_full | Radiation-induced eosinophil increase ratio predicts patient outcomes in non-small celllung cancer |
| title_fullStr | Radiation-induced eosinophil increase ratio predicts patient outcomes in non-small celllung cancer |
| title_full_unstemmed | Radiation-induced eosinophil increase ratio predicts patient outcomes in non-small celllung cancer |
| title_short | Radiation-induced eosinophil increase ratio predicts patient outcomes in non-small celllung cancer |
| title_sort | radiation induced eosinophil increase ratio predicts patient outcomes in non small celllung cancer |
| topic | radiotherapy dose-volume histogram parameters eosinophil increase ratio non-small cell lung cancer Sequential chemoradiotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.999555/full |
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