Arenavirus Budding: A Common Pathway with Mechanistic Differences
The Arenaviridae is a diverse and growing family of viruses that includes several agents responsible for important human diseases. Despite the importance of this family for public health, particularly in Africa and South America, much of its biology remains poorly understood. However, in recent year...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-01-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/5/2/528 |
| _version_ | 1828241673850716160 |
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| author | Svenja Wolff Hideki Ebihara Allison Groseth |
| author_facet | Svenja Wolff Hideki Ebihara Allison Groseth |
| author_sort | Svenja Wolff |
| collection | DOAJ |
| description | The Arenaviridae is a diverse and growing family of viruses that includes several agents responsible for important human diseases. Despite the importance of this family for public health, particularly in Africa and South America, much of its biology remains poorly understood. However, in recent years significant progress has been made in this regard, particularly relating to the formation and release of new enveloped virions, which is an essential step in the viral lifecycle. While this process is mediated chiefly by the viral matrix protein Z, recent evidence suggests that for some viruses the nucleoprotein (NP) is also required to enhance the budding process. Here we highlight and compare the distinct budding mechanisms of different arenaviruses, concentrating on the role of the matrix protein Z, its known late domain sequences, and the involvement of cellular endosomal sorting complex required for transport (ESCRT) pathway components. Finally we address the recently described roles for the nucleoprotein NP in budding and ribonucleoprotein complex (RNP) incorporation, as well as discussing possible mechanisms related to its involvement. |
| first_indexed | 2024-04-12T22:03:02Z |
| format | Article |
| id | doaj.art-89dc7ee42b004f9c94a202c6fc99c077 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-12T22:03:02Z |
| publishDate | 2013-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-89dc7ee42b004f9c94a202c6fc99c0772022-12-22T03:15:03ZengMDPI AGViruses1999-49152013-01-015252854910.3390/v5020528Arenavirus Budding: A Common Pathway with Mechanistic DifferencesSvenja WolffHideki EbiharaAllison GrosethThe Arenaviridae is a diverse and growing family of viruses that includes several agents responsible for important human diseases. Despite the importance of this family for public health, particularly in Africa and South America, much of its biology remains poorly understood. However, in recent years significant progress has been made in this regard, particularly relating to the formation and release of new enveloped virions, which is an essential step in the viral lifecycle. While this process is mediated chiefly by the viral matrix protein Z, recent evidence suggests that for some viruses the nucleoprotein (NP) is also required to enhance the budding process. Here we highlight and compare the distinct budding mechanisms of different arenaviruses, concentrating on the role of the matrix protein Z, its known late domain sequences, and the involvement of cellular endosomal sorting complex required for transport (ESCRT) pathway components. Finally we address the recently described roles for the nucleoprotein NP in budding and ribonucleoprotein complex (RNP) incorporation, as well as discussing possible mechanisms related to its involvement.http://www.mdpi.com/1999-4915/5/2/528arenavirusbuddingESCRT pathwaymatrix proteinnucleoproteinlate domain |
| spellingShingle | Svenja Wolff Hideki Ebihara Allison Groseth Arenavirus Budding: A Common Pathway with Mechanistic Differences Viruses arenavirus budding ESCRT pathway matrix protein nucleoprotein late domain |
| title | Arenavirus Budding: A Common Pathway with Mechanistic Differences |
| title_full | Arenavirus Budding: A Common Pathway with Mechanistic Differences |
| title_fullStr | Arenavirus Budding: A Common Pathway with Mechanistic Differences |
| title_full_unstemmed | Arenavirus Budding: A Common Pathway with Mechanistic Differences |
| title_short | Arenavirus Budding: A Common Pathway with Mechanistic Differences |
| title_sort | arenavirus budding a common pathway with mechanistic differences |
| topic | arenavirus budding ESCRT pathway matrix protein nucleoprotein late domain |
| url | http://www.mdpi.com/1999-4915/5/2/528 |
| work_keys_str_mv | AT svenjawolff arenavirusbuddingacommonpathwaywithmechanisticdifferences AT hidekiebihara arenavirusbuddingacommonpathwaywithmechanisticdifferences AT allisongroseth arenavirusbuddingacommonpathwaywithmechanisticdifferences |