Co-Delivery of Methotrexate and Nanohydroxyapatite with Polyethylene Glycol Polymers for Chemotherapy of Osteosarcoma

Co-Delivery of Methotrexate and Nanohydroxyapatite with Polyethylene Glycol Polymers for Chemotherapy of Osteosarcoma

Neoadjuvant chemotherapy is an alternative treatment modality for tumors. Methotrexate (MTX) has been often used as a neoadjuvant chemotherapy reagent for osteosarcoma surgery. However, the large dosage, high toxicity, strong drug resistance, and poor improvement of bone erosion restricted the utili...

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Bibliographic Details
Main Authors: Lingbin Ou, Qiongyu Zhang, Yong Chang, Ning Xia
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Micromachines
Subjects:
osteosarcoma
methotrexate
nanohydroxyapatite
polyethylene glycol
drug delivery
Online Access:https://www.mdpi.com/2072-666X/14/4/757

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