Simultaneous colonic T-cell lymphoma and graft-versus-host disease: A rare diagnosis
Cutaneous T-cell lymphoma (CTCL) presenting as mycosis fungoides is typically localized to the skin and occasional draining lymph nodes. We present a 46-year-old man with refractory CTCL status-post allogeneic stem cell transplant who was biopsied for diarrhea and abdominal pain. These gastrointesti...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Human Pathology: Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214330021000365 |
| _version_ | 1818740517337300992 |
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| author | Savanah D. Gisriel Kenneth W. Hung Demetrios T. Braddock Stuart Seropian Francine M. Foss Marie E. Robert Mina L. Xu |
| author_facet | Savanah D. Gisriel Kenneth W. Hung Demetrios T. Braddock Stuart Seropian Francine M. Foss Marie E. Robert Mina L. Xu |
| author_sort | Savanah D. Gisriel |
| collection | DOAJ |
| description | Cutaneous T-cell lymphoma (CTCL) presenting as mycosis fungoides is typically localized to the skin and occasional draining lymph nodes. We present a 46-year-old man with refractory CTCL status-post allogeneic stem cell transplant who was biopsied for diarrhea and abdominal pain. These gastrointestinal biopsies revealed not only graft-versus-host-disease but also a clonal atypical lymphoid infiltrate with the same morphology and immunophenotype as the patient’s known CTCL. We discuss the differential diagnosis of CTCL metastatic to the intestinal mucosa versus post-transplant lymphoproliferative disorder and present a review of the literature. This case demonstrates challenging diagnostic workups in limited tissue samples as well as critical clinical implications. |
| first_indexed | 2024-12-18T01:41:59Z |
| format | Article |
| id | doaj.art-89ddd6eac26d4a49a62399c3a4599210 |
| institution | Directory Open Access Journal |
| issn | 2214-3300 |
| language | English |
| last_indexed | 2024-12-18T01:41:59Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Pathology: Case Reports |
| spelling | doaj.art-89ddd6eac26d4a49a62399c3a45992102022-12-21T21:25:17ZengElsevierHuman Pathology: Case Reports2214-33002021-06-0124200507Simultaneous colonic T-cell lymphoma and graft-versus-host disease: A rare diagnosisSavanah D. Gisriel0Kenneth W. Hung1Demetrios T. Braddock2Stuart Seropian3Francine M. Foss4Marie E. Robert5Mina L. Xu6Department of Pathology & Laboratory Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06520-8023, USASection of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06520-8023, USADepartment of Pathology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06520-8023, USASection of Hematology, Department of Internal Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06520-8023, USASection of Hematology, Department of Internal Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06520-8023, USADepartment of Pathology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06520-8023, USADepartment of Pathology & Laboratory Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06520-8023, USA; Corresponding author.Cutaneous T-cell lymphoma (CTCL) presenting as mycosis fungoides is typically localized to the skin and occasional draining lymph nodes. We present a 46-year-old man with refractory CTCL status-post allogeneic stem cell transplant who was biopsied for diarrhea and abdominal pain. These gastrointestinal biopsies revealed not only graft-versus-host-disease but also a clonal atypical lymphoid infiltrate with the same morphology and immunophenotype as the patient’s known CTCL. We discuss the differential diagnosis of CTCL metastatic to the intestinal mucosa versus post-transplant lymphoproliferative disorder and present a review of the literature. This case demonstrates challenging diagnostic workups in limited tissue samples as well as critical clinical implications.http://www.sciencedirect.com/science/article/pii/S2214330021000365Mycosis fungoidesCutaneous T-cell lymphomaGraft-versus-host diseaseColon |
| spellingShingle | Savanah D. Gisriel Kenneth W. Hung Demetrios T. Braddock Stuart Seropian Francine M. Foss Marie E. Robert Mina L. Xu Simultaneous colonic T-cell lymphoma and graft-versus-host disease: A rare diagnosis Human Pathology: Case Reports Mycosis fungoides Cutaneous T-cell lymphoma Graft-versus-host disease Colon |
| title | Simultaneous colonic T-cell lymphoma and graft-versus-host disease: A rare diagnosis |
| title_full | Simultaneous colonic T-cell lymphoma and graft-versus-host disease: A rare diagnosis |
| title_fullStr | Simultaneous colonic T-cell lymphoma and graft-versus-host disease: A rare diagnosis |
| title_full_unstemmed | Simultaneous colonic T-cell lymphoma and graft-versus-host disease: A rare diagnosis |
| title_short | Simultaneous colonic T-cell lymphoma and graft-versus-host disease: A rare diagnosis |
| title_sort | simultaneous colonic t cell lymphoma and graft versus host disease a rare diagnosis |
| topic | Mycosis fungoides Cutaneous T-cell lymphoma Graft-versus-host disease Colon |
| url | http://www.sciencedirect.com/science/article/pii/S2214330021000365 |
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