Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors
The aim of the present study was to determine if phenobarbital affects the nociception threshold. Systemic (1-20 mg/kg) phenobarbital administration dose dependently induced hyperalgesia in the tail-flick, hot-plate and formalin tests in rats and in the abdominal constriction test in mice. Formalin...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2001-03-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300015 |
| _version_ | 1818505080169562112 |
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| author | C.M. Yokoro S.M.S. Pesquero R.M.M. Turchetti-Maia J.N. Francischi M.A.K.F. Tatsuo |
| author_facet | C.M. Yokoro S.M.S. Pesquero R.M.M. Turchetti-Maia J.N. Francischi M.A.K.F. Tatsuo |
| author_sort | C.M. Yokoro |
| collection | DOAJ |
| description | The aim of the present study was to determine if phenobarbital affects the nociception threshold. Systemic (1-20 mg/kg) phenobarbital administration dose dependently induced hyperalgesia in the tail-flick, hot-plate and formalin tests in rats and in the abdominal constriction test in mice. Formalin and abdominal constriction tests were the most sensitive procedures for the detection of hyperalgesia in response to phenobarbital compared with the tail-flick and hot-plate tests. The hyperalgesia induced by systemic phenobarbital was blocked by previous administration of 1 mg/kg ip picrotoxin or either 1-2 mg/kg sc or 10 ng icv bicuculline. Intracerebroventricular phenobarbital administration (5 µg) induced hyperalgesia in the tail-flick test. In contrast, intrathecal phenobarbital administration (5 µg) induced antinociception and blocked systemic-induced hyperalgesia in this test. We suggest that phenobarbital may mediate hyperalgesia through GABA-A receptors at supraspinal levels and antinociception through the same kind of receptors at spinal levels. |
| first_indexed | 2024-12-10T21:45:52Z |
| format | Article |
| id | doaj.art-89de08b8e74a4e2780115564c59c1759 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-10T21:45:52Z |
| publishDate | 2001-03-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-89de08b8e74a4e2780115564c59c17592022-12-22T01:32:22ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2001-03-0134339740510.1590/S0100-879X2001000300015Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptorsC.M. YokoroS.M.S. PesqueroR.M.M. Turchetti-MaiaJ.N. FrancischiM.A.K.F. TatsuoThe aim of the present study was to determine if phenobarbital affects the nociception threshold. Systemic (1-20 mg/kg) phenobarbital administration dose dependently induced hyperalgesia in the tail-flick, hot-plate and formalin tests in rats and in the abdominal constriction test in mice. Formalin and abdominal constriction tests were the most sensitive procedures for the detection of hyperalgesia in response to phenobarbital compared with the tail-flick and hot-plate tests. The hyperalgesia induced by systemic phenobarbital was blocked by previous administration of 1 mg/kg ip picrotoxin or either 1-2 mg/kg sc or 10 ng icv bicuculline. Intracerebroventricular phenobarbital administration (5 µg) induced hyperalgesia in the tail-flick test. In contrast, intrathecal phenobarbital administration (5 µg) induced antinociception and blocked systemic-induced hyperalgesia in this test. We suggest that phenobarbital may mediate hyperalgesia through GABA-A receptors at supraspinal levels and antinociception through the same kind of receptors at spinal levels.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300015phenobarbitalhyperalgesiaGABA-A receptors |
| spellingShingle | C.M. Yokoro S.M.S. Pesquero R.M.M. Turchetti-Maia J.N. Francischi M.A.K.F. Tatsuo Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors Brazilian Journal of Medical and Biological Research phenobarbital hyperalgesia GABA-A receptors |
| title | Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors |
| title_full | Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors |
| title_fullStr | Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors |
| title_full_unstemmed | Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors |
| title_short | Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors |
| title_sort | acute phenobarbital administration induces hyperalgesia pharmacological evidence for the involvement of supraspinal gaba a receptors |
| topic | phenobarbital hyperalgesia GABA-A receptors |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300015 |
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