Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors

Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors

The aim of the present study was to determine if phenobarbital affects the nociception threshold. Systemic (1-20 mg/kg) phenobarbital administration dose dependently induced hyperalgesia in the tail-flick, hot-plate and formalin tests in rats and in the abdominal constriction test in mice. Formalin...

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Bibliographic Details
Main Authors: C.M. Yokoro, S.M.S. Pesquero, R.M.M. Turchetti-Maia, J.N. Francischi, M.A.K.F. Tatsuo
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2001-03-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
phenobarbital
hyperalgesia
GABA-A receptors
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300015

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