Probable Causes of Alzheimer’s Disease
A three-part mechanism is proposed for the induction of Alzheimer’s disease: (1) decreased blood lactic acid; (2) increased blood ceramide and adipokines; (3) decreased blood folic acid. The age-related nature of these mechanisms comes from age-associated decreased muscle mass, increased visceral fa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Sci |
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| Online Access: | https://www.mdpi.com/2413-4155/3/1/16 |
| _version_ | 1797416302746271744 |
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| author | James David Adams |
| author_facet | James David Adams |
| author_sort | James David Adams |
| collection | DOAJ |
| description | A three-part mechanism is proposed for the induction of Alzheimer’s disease: (1) decreased blood lactic acid; (2) increased blood ceramide and adipokines; (3) decreased blood folic acid. The age-related nature of these mechanisms comes from age-associated decreased muscle mass, increased visceral fat and changes in diet. This mechanism also explains why many people do not develop Alzheimer’s disease. Simple changes in lifestyle and diet can prevent Alzheimer’s disease. Alzheimer’s disease is caused by a cascade of events that culminates in damage to the blood–brain barrier and damage to neurons. The blood–brain barrier keeps toxic molecules out of the brain and retains essential molecules in the brain. Lactic acid is a nutrient to the brain and is produced by exercise. Damage to endothelial cells and pericytes by inadequate lactic acid leads to blood–brain barrier damage and brain damage. Inadequate folate intake and oxidative stress induced by activation of transient receptor potential cation channels and endothelial nitric oxide synthase damage the blood–brain barrier. NAD depletion due to inadequate intake of nicotinamide and alterations in the kynurenine pathway damages neurons. Changes in microRNA levels may be the terminal events that cause neuronal death leading to Alzheimer’s disease. A new mechanism of Alzheimer’s disease induction is presented involving lactic acid, ceramide, IL-1β, tumor necrosis factor α, folate, nicotinamide, kynurenine metabolites and microRNA. |
| first_indexed | 2024-03-09T06:01:26Z |
| format | Article |
| id | doaj.art-89de1c37cc824abd9c8aadc3c46c0e08 |
| institution | Directory Open Access Journal |
| issn | 2413-4155 |
| language | English |
| last_indexed | 2024-03-09T06:01:26Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sci |
| spelling | doaj.art-89de1c37cc824abd9c8aadc3c46c0e082023-12-03T12:08:22ZengMDPI AGSci2413-41552021-03-01311610.3390/sci3010016Probable Causes of Alzheimer’s DiseaseJames David Adams0Independent Researcher, La Crescenta, CA 91214, USAA three-part mechanism is proposed for the induction of Alzheimer’s disease: (1) decreased blood lactic acid; (2) increased blood ceramide and adipokines; (3) decreased blood folic acid. The age-related nature of these mechanisms comes from age-associated decreased muscle mass, increased visceral fat and changes in diet. This mechanism also explains why many people do not develop Alzheimer’s disease. Simple changes in lifestyle and diet can prevent Alzheimer’s disease. Alzheimer’s disease is caused by a cascade of events that culminates in damage to the blood–brain barrier and damage to neurons. The blood–brain barrier keeps toxic molecules out of the brain and retains essential molecules in the brain. Lactic acid is a nutrient to the brain and is produced by exercise. Damage to endothelial cells and pericytes by inadequate lactic acid leads to blood–brain barrier damage and brain damage. Inadequate folate intake and oxidative stress induced by activation of transient receptor potential cation channels and endothelial nitric oxide synthase damage the blood–brain barrier. NAD depletion due to inadequate intake of nicotinamide and alterations in the kynurenine pathway damages neurons. Changes in microRNA levels may be the terminal events that cause neuronal death leading to Alzheimer’s disease. A new mechanism of Alzheimer’s disease induction is presented involving lactic acid, ceramide, IL-1β, tumor necrosis factor α, folate, nicotinamide, kynurenine metabolites and microRNA.https://www.mdpi.com/2413-4155/3/1/16lactic acidceramidefolatenicotinamideAlzheimer’s disease |
| spellingShingle | James David Adams Probable Causes of Alzheimer’s Disease Sci lactic acid ceramide folate nicotinamide Alzheimer’s disease |
| title | Probable Causes of Alzheimer’s Disease |
| title_full | Probable Causes of Alzheimer’s Disease |
| title_fullStr | Probable Causes of Alzheimer’s Disease |
| title_full_unstemmed | Probable Causes of Alzheimer’s Disease |
| title_short | Probable Causes of Alzheimer’s Disease |
| title_sort | probable causes of alzheimer s disease |
| topic | lactic acid ceramide folate nicotinamide Alzheimer’s disease |
| url | https://www.mdpi.com/2413-4155/3/1/16 |
| work_keys_str_mv | AT jamesdavidadams probablecausesofalzheimersdisease |