Uptake of vaccination in older Indian patients with cancer: A cross-sectional observational study
Background: Older patients with cancer are at a higher risk of invasive infections. Vaccination is an effective approach to decrease the mortality and morbidity associated with infections. Objectives: Our primary objective was to evaluate the proportion of older patients with cancer who had received...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Cancer Research, Statistics, and Treatment |
| Subjects: | |
| Online Access: | http://www.crstonline.com/article.asp?issn=2590-3233;year=2023;volume=6;issue=1;spage=52;epage=61;aulast=Sabu |
| _version_ | 1797824449463975936 |
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| author | Tabitha M Sabu Vanita Noronha Abhijith R Rao Anita Kumar Shreya Gattani Anant Ramaswamy Anupa Pillai Ratan Dhekale Renita Castelino Sharath Kumar Arshiya Sehgal Pallavi Rana Vikram Gota Rajendra Badwe Kumar Prabhash |
| author_facet | Tabitha M Sabu Vanita Noronha Abhijith R Rao Anita Kumar Shreya Gattani Anant Ramaswamy Anupa Pillai Ratan Dhekale Renita Castelino Sharath Kumar Arshiya Sehgal Pallavi Rana Vikram Gota Rajendra Badwe Kumar Prabhash |
| author_sort | Tabitha M Sabu |
| collection | DOAJ |
| description | Background: Older patients with cancer are at a higher risk of invasive infections. Vaccination is an effective approach to decrease the mortality and morbidity associated with infections.
Objectives: Our primary objective was to evaluate the proportion of older patients with cancer who had received routine vaccinations against pneumococcal, influenza, and coronavirus disease 2019 (COVID-19). Our secondary objective was to identify the factors associated with vaccine uptake such as age, sex, education, marital status, comorbidities, and place of residence.
Materials and Methods: This cross-sectional observational study was conducted in the geriatric oncology outpatient clinic of the Department of Medical Oncology at the Tata Memorial Hospital, a tertiary care cancer hospital in Mumbai, India, from February 2020 to January 2023. We included all patients aged ≥60 years who were evaluated in the geriatric oncology clinic during the study period and for whom the immunization details were available. The uptake of COVID-19 vaccine was calculated from March 2021 onwards, which was when the COVID-19 vaccine became available to patients aged ≥60 years in India.
Results: We enrolled 1762 patients; 1342 (76.2%) were male. The mean age was 68.4 (SD, 5.8) years; 795 (45%) patients were from the west zone of India. Only 12 (0.68%) patients had received the pneumococcal vaccine, and 13 (0.7%) had received the influenza vaccine. At least one dose of the COVID-19 vaccine had been taken by 1302 of 1562 patients (83.3%). On univariate logistic regression, education, marital status, geographic zone of residence, and primary tumor site were correlated with the uptake of COVID-19 vaccine. Factors associated with a greater COVID-19 vaccine uptake included education (up to Std 10 and higher vs. less than Std 10: Odds Ratio [OR], 1.46; 95% confidence interval [CI], 1.07-1.99; P = 0.018, and illiterate vs. less than Std 10: OR, 0.70; 95% CI, 0.50-0.99; P = 0.041), marital status (unmarried vs. married: OR, 0.27; 95% CI, 0.08-1.08; P = 0.046, and widow/widower vs. married: OR, 0.67; 95% CI, 0.48-0.94; P = 0.017), lung and gastrointestinal vs. head-and-neck primary tumors (lung cancer vs. head-and-neck cancer: OR, 1.60; 95% CI, 1.02–2.47; P = 0.038, and gastrointestinal vs .head-and-neck cancer: OR, 2.18; 95% CI, 1.37-3.42; P < 0.001), and place of residence (west zone vs. central India: OR, 0.34; 95% CI, 0.13-0.75; P = 0.015).
Conclusion: Fewer than 1 in 100 older Indian patients with cancer receive routine immunization with influenza and pneumococcal vaccines. Hearteningly, the uptake of COVID-19 vaccination in older Indian patients with cancer is over 80%, possibly due to the global recognition of its importance during the pandemic. Similar measures as those used to increase the uptake of COVID-19 vaccines during the pandemic may be beneficial to increase the uptake of routine vaccinations (Clinical Trials Registry, India: CTRI/2020/04/024675). |
| first_indexed | 2024-03-13T10:39:08Z |
| format | Article |
| id | doaj.art-89e3eb3c233346268505e677a9d550f0 |
| institution | Directory Open Access Journal |
| issn | 2590-3233 2590-3225 |
| language | English |
| last_indexed | 2024-03-13T10:39:08Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Cancer Research, Statistics, and Treatment |
| spelling | doaj.art-89e3eb3c233346268505e677a9d550f02023-05-18T05:04:23ZengWolters Kluwer Medknow PublicationsCancer Research, Statistics, and Treatment2590-32332590-32252023-01-0161526110.4103/crst.crst_29_23Uptake of vaccination in older Indian patients with cancer: A cross-sectional observational studyTabitha M SabuVanita NoronhaAbhijith R RaoAnita KumarShreya GattaniAnant RamaswamyAnupa PillaiRatan DhekaleRenita CastelinoSharath KumarArshiya SehgalPallavi RanaVikram GotaRajendra BadweKumar PrabhashBackground: Older patients with cancer are at a higher risk of invasive infections. Vaccination is an effective approach to decrease the mortality and morbidity associated with infections. Objectives: Our primary objective was to evaluate the proportion of older patients with cancer who had received routine vaccinations against pneumococcal, influenza, and coronavirus disease 2019 (COVID-19). Our secondary objective was to identify the factors associated with vaccine uptake such as age, sex, education, marital status, comorbidities, and place of residence. Materials and Methods: This cross-sectional observational study was conducted in the geriatric oncology outpatient clinic of the Department of Medical Oncology at the Tata Memorial Hospital, a tertiary care cancer hospital in Mumbai, India, from February 2020 to January 2023. We included all patients aged ≥60 years who were evaluated in the geriatric oncology clinic during the study period and for whom the immunization details were available. The uptake of COVID-19 vaccine was calculated from March 2021 onwards, which was when the COVID-19 vaccine became available to patients aged ≥60 years in India. Results: We enrolled 1762 patients; 1342 (76.2%) were male. The mean age was 68.4 (SD, 5.8) years; 795 (45%) patients were from the west zone of India. Only 12 (0.68%) patients had received the pneumococcal vaccine, and 13 (0.7%) had received the influenza vaccine. At least one dose of the COVID-19 vaccine had been taken by 1302 of 1562 patients (83.3%). On univariate logistic regression, education, marital status, geographic zone of residence, and primary tumor site were correlated with the uptake of COVID-19 vaccine. Factors associated with a greater COVID-19 vaccine uptake included education (up to Std 10 and higher vs. less than Std 10: Odds Ratio [OR], 1.46; 95% confidence interval [CI], 1.07-1.99; P = 0.018, and illiterate vs. less than Std 10: OR, 0.70; 95% CI, 0.50-0.99; P = 0.041), marital status (unmarried vs. married: OR, 0.27; 95% CI, 0.08-1.08; P = 0.046, and widow/widower vs. married: OR, 0.67; 95% CI, 0.48-0.94; P = 0.017), lung and gastrointestinal vs. head-and-neck primary tumors (lung cancer vs. head-and-neck cancer: OR, 1.60; 95% CI, 1.02–2.47; P = 0.038, and gastrointestinal vs .head-and-neck cancer: OR, 2.18; 95% CI, 1.37-3.42; P < 0.001), and place of residence (west zone vs. central India: OR, 0.34; 95% CI, 0.13-0.75; P = 0.015). Conclusion: Fewer than 1 in 100 older Indian patients with cancer receive routine immunization with influenza and pneumococcal vaccines. Hearteningly, the uptake of COVID-19 vaccination in older Indian patients with cancer is over 80%, possibly due to the global recognition of its importance during the pandemic. Similar measures as those used to increase the uptake of COVID-19 vaccines during the pandemic may be beneficial to increase the uptake of routine vaccinations (Clinical Trials Registry, India: CTRI/2020/04/024675).http://www.crstonline.com/article.asp?issn=2590-3233;year=2023;volume=6;issue=1;spage=52;epage=61;aulast=Sabugeriatricmorbiditymortalityvaccination |
| spellingShingle | Tabitha M Sabu Vanita Noronha Abhijith R Rao Anita Kumar Shreya Gattani Anant Ramaswamy Anupa Pillai Ratan Dhekale Renita Castelino Sharath Kumar Arshiya Sehgal Pallavi Rana Vikram Gota Rajendra Badwe Kumar Prabhash Uptake of vaccination in older Indian patients with cancer: A cross-sectional observational study Cancer Research, Statistics, and Treatment geriatric morbidity mortality vaccination |
| title | Uptake of vaccination in older Indian patients with cancer: A cross-sectional observational study |
| title_full | Uptake of vaccination in older Indian patients with cancer: A cross-sectional observational study |
| title_fullStr | Uptake of vaccination in older Indian patients with cancer: A cross-sectional observational study |
| title_full_unstemmed | Uptake of vaccination in older Indian patients with cancer: A cross-sectional observational study |
| title_short | Uptake of vaccination in older Indian patients with cancer: A cross-sectional observational study |
| title_sort | uptake of vaccination in older indian patients with cancer a cross sectional observational study |
| topic | geriatric morbidity mortality vaccination |
| url | http://www.crstonline.com/article.asp?issn=2590-3233;year=2023;volume=6;issue=1;spage=52;epage=61;aulast=Sabu |
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