Mechanical properties of native and decellularized reproductive tissues: insights for tissue engineering strategies
Abstract Understanding the mechanical properties and porosity of reproductive tissues is vital for regenerative medicine and tissue engineering. This study investigated the changes in Young's modulus (YM), storage modulus (E′), loss modulus (Eʺ), and porosity of native and decellularized bovine...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-57867-5 |
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| author | R. Franko Y. Franko E. Ribes Martinez G. A. Ferronato I. Heinzelmann N. Grechi S. Devkota P. K. Fontes R. Coeti T. S. I. Oshiro M. A. M. M. Ferraz |
| author_facet | R. Franko Y. Franko E. Ribes Martinez G. A. Ferronato I. Heinzelmann N. Grechi S. Devkota P. K. Fontes R. Coeti T. S. I. Oshiro M. A. M. M. Ferraz |
| author_sort | R. Franko |
| collection | DOAJ |
| description | Abstract Understanding the mechanical properties and porosity of reproductive tissues is vital for regenerative medicine and tissue engineering. This study investigated the changes in Young's modulus (YM), storage modulus (E′), loss modulus (Eʺ), and porosity of native and decellularized bovine reproductive tissues during the estrous cycle. Testis tunica albuginea had significantly higher YM, E′, and Eʺ than the inner testis, indicating greater stiffness and viscoelasticity. Endometrium showed no distinct differences in YM, E′, or Eʺ across the estrous cycle or between horns. Ovaries exhibited significant variations in YM, E′, Eʺ, and porosity, with higher YM and E′ in the ipsilateral cortex and medulla during the luteal phase. Decellularized ovarian tissues displayed increased porosity. The oviduct displayed no significant differences in YM or E′ in the isthmus, but the contralateral ampulla had reduced YM and E′ in the luteal phase. These findings offer valuable insights into the dynamic mechanical properties and porosity of reproductive tissues, facilitating the development of biomimetic scaffolds for tissue engineering applications. |
| first_indexed | 2024-04-24T16:17:44Z |
| format | Article |
| id | doaj.art-89e477aa49fc483a84fdb5a774129023 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T16:17:44Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-89e477aa49fc483a84fdb5a7741290232024-03-31T11:21:29ZengNature PortfolioScientific Reports2045-23222024-03-0114111410.1038/s41598-024-57867-5Mechanical properties of native and decellularized reproductive tissues: insights for tissue engineering strategiesR. Franko0Y. Franko1E. Ribes Martinez2G. A. Ferronato3I. Heinzelmann4N. Grechi5S. Devkota6P. K. Fontes7R. Coeti8T. S. I. Oshiro9M. A. M. M. Ferraz10Clinic of Ruminants, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität MünchenClinic of Ruminants, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität MünchenClinic of Ruminants, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität MünchenClinic of Ruminants, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität MünchenClinic of Ruminants, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität MünchenClinic of Ruminants, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität MünchenClinic of Ruminants, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität MünchenCenter of Natural and Human Sciences, Federal University of ABCClinic of Ruminants, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität MünchenDepartment of Surgery, Faculty of Veterinary Medicine and Zootechny, University of São PauloClinic of Ruminants, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität MünchenAbstract Understanding the mechanical properties and porosity of reproductive tissues is vital for regenerative medicine and tissue engineering. This study investigated the changes in Young's modulus (YM), storage modulus (E′), loss modulus (Eʺ), and porosity of native and decellularized bovine reproductive tissues during the estrous cycle. Testis tunica albuginea had significantly higher YM, E′, and Eʺ than the inner testis, indicating greater stiffness and viscoelasticity. Endometrium showed no distinct differences in YM, E′, or Eʺ across the estrous cycle or between horns. Ovaries exhibited significant variations in YM, E′, Eʺ, and porosity, with higher YM and E′ in the ipsilateral cortex and medulla during the luteal phase. Decellularized ovarian tissues displayed increased porosity. The oviduct displayed no significant differences in YM or E′ in the isthmus, but the contralateral ampulla had reduced YM and E′ in the luteal phase. These findings offer valuable insights into the dynamic mechanical properties and porosity of reproductive tissues, facilitating the development of biomimetic scaffolds for tissue engineering applications.https://doi.org/10.1038/s41598-024-57867-5Young’s modulusPorosityBioengineeringStiffness |
| spellingShingle | R. Franko Y. Franko E. Ribes Martinez G. A. Ferronato I. Heinzelmann N. Grechi S. Devkota P. K. Fontes R. Coeti T. S. I. Oshiro M. A. M. M. Ferraz Mechanical properties of native and decellularized reproductive tissues: insights for tissue engineering strategies Scientific Reports Young’s modulus Porosity Bioengineering Stiffness |
| title | Mechanical properties of native and decellularized reproductive tissues: insights for tissue engineering strategies |
| title_full | Mechanical properties of native and decellularized reproductive tissues: insights for tissue engineering strategies |
| title_fullStr | Mechanical properties of native and decellularized reproductive tissues: insights for tissue engineering strategies |
| title_full_unstemmed | Mechanical properties of native and decellularized reproductive tissues: insights for tissue engineering strategies |
| title_short | Mechanical properties of native and decellularized reproductive tissues: insights for tissue engineering strategies |
| title_sort | mechanical properties of native and decellularized reproductive tissues insights for tissue engineering strategies |
| topic | Young’s modulus Porosity Bioengineering Stiffness |
| url | https://doi.org/10.1038/s41598-024-57867-5 |
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