Plasminogen Deficiency and Amiloride Mitigate Angiotensin II–Induced Hypertension in Type 1 Diabetic Mice Suggesting Effects Through the Epithelial Sodium Channel

Plasminogen Deficiency and Amiloride Mitigate Angiotensin II–Induced Hypertension in Type 1 Diabetic Mice Suggesting Effects Through the Epithelial Sodium Channel

Background Diabetic nephropathy is a common diabetes mellitus complication associated with hypertension, proteinuria, and excretion of urinary plasmin that activates the epithelial sodium channel, ENaC, in vitro. Here we hypothesized that the deletion of plasminogen and amiloride treatment protect a...

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Bibliographic Details
Main Authors: Henrik Andersen, Maria Høj Hansen, Kristian B. Buhl, Mette Stæhr, Ulla G. Friis, Camilla Enggaard, Shanya Supramaniyam, Ida K. Lund, Per Svenningsen, Pernille B. L. Hansen, Boye L. Jensen
Format: Article
Language:English
Published: Wiley 2020-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
albuminuria
aldosterone
protease
renin
sodium channels
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.016387

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