Binding and Dynamics Demonstrate the Destabilization of Ligand Binding for the S688Y Mutation in the NMDA Receptor GluN1 Subunit

Binding and Dynamics Demonstrate the Destabilization of Ligand Binding for the S688Y Mutation in the NMDA Receptor GluN1 Subunit

Encephalopathies are brain dysfunctions that lead to cognitive, sensory, and motor development impairments. Recently, the identification of several mutations within the <i>N</i>-methyl-D-aspartate receptor (NMDAR) have been identified as significant in the etiology of this group of condi...

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Bibliographic Details
Main Authors: Jake Zheng Chen, William Bret Church, Karine Bastard, Anthony P. Duff, Thomas Balle
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
molecular dynamics
NMDA receptor
membrane protein
ligand binding
encephalopathies
Online Access:https://www.mdpi.com/1420-3049/28/10/4108

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