Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetes
Introduction Type 1 diabetes (T1D) is associated with higher fracture risk. However, few studies have investigated the relationship between severe hypoglycemia and fracture risk in patients with T1D, and the results are controversial. Besides, none has investigated the risk factors for fracture in A...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2021-08-01
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| Series: | BMJ Open Diabetes Research & Care |
| Online Access: | https://drc.bmj.com/content/9/1/e002099.full |
| _version_ | 1819112336860905472 |
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| author | Takanari Kitazono Yuji Komorita Yasutaka Maeda Masae Minami Rie Yoshioka |
| author_facet | Takanari Kitazono Yuji Komorita Yasutaka Maeda Masae Minami Rie Yoshioka |
| author_sort | Takanari Kitazono |
| collection | DOAJ |
| description | Introduction Type 1 diabetes (T1D) is associated with higher fracture risk. However, few studies have investigated the relationship between severe hypoglycemia and fracture risk in patients with T1D, and the results are controversial. Besides, none has investigated the risk factors for fracture in Asian patients with T1D. The aim of the present study was to investigate the prevalence of bone fracture and its relationship between severe hypoglycemia and other risk factors in Japanese patients with T1D.Research design and methods The single-center cross-sectional study enrolled 388 Japanese patients with T1D (mean age, 45.2 years; women, 60.4%; mean duration of diabetes, 16.6 years) between October 2019 and April 2020. The occurrence and circumstances of any fracture after the diagnosis of T1D were identified using a self-administered questionnaire. The main outcomes were any anatomic site of fracture and fall-related fracture. Severe hypoglycemia was defined as an episode of hypoglycemia that required the assistance of others to achieve recovery.Results A total of 92 fractures occurred in 64 patients, and 59 fractures (64%) were fall-related. Only one participant experienced fracture within the 10 years following their diagnosis of diabetes. In logistic regression analysis, the multivariate-adjusted ORs (95% CIs) of a history of severe hypoglycemia were 2.11 (1.11 to 4.09) for any fracture and 1.91 (0.93 to 4.02) for fall-related fracture. Fourteen of 18 participants with multiple episodes of any type of fracture had a history of severe hypoglycemia (p<0.001 vs no fracture).Conclusions We have shown that a history of severe hypoglycemia is significantly associated with a higher risk of bone fracture in Japanese patients with T1D. |
| first_indexed | 2024-12-22T04:11:54Z |
| format | Article |
| id | doaj.art-89e579a960a44084b080a09f146490c2 |
| institution | Directory Open Access Journal |
| issn | 2052-4897 |
| language | English |
| last_indexed | 2024-12-22T04:11:54Z |
| publishDate | 2021-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Diabetes Research & Care |
| spelling | doaj.art-89e579a960a44084b080a09f146490c22022-12-21T18:39:30ZengBMJ Publishing GroupBMJ Open Diabetes Research & Care2052-48972021-08-019110.1136/bmjdrc-2020-002099Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetesTakanari Kitazono0Yuji Komorita1Yasutaka Maeda2Masae Minami3Rie Yoshioka4Department of Medicine and Clinical Science, Kyusyu University Graduate School of Medicine, Fukuoka, JapanDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan2Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanMinami Diabetes Clinical Research Center, Fukuoka, JapanMinami Diabetes Clinical Research Center, Fukuoka, JapanIntroduction Type 1 diabetes (T1D) is associated with higher fracture risk. However, few studies have investigated the relationship between severe hypoglycemia and fracture risk in patients with T1D, and the results are controversial. Besides, none has investigated the risk factors for fracture in Asian patients with T1D. The aim of the present study was to investigate the prevalence of bone fracture and its relationship between severe hypoglycemia and other risk factors in Japanese patients with T1D.Research design and methods The single-center cross-sectional study enrolled 388 Japanese patients with T1D (mean age, 45.2 years; women, 60.4%; mean duration of diabetes, 16.6 years) between October 2019 and April 2020. The occurrence and circumstances of any fracture after the diagnosis of T1D were identified using a self-administered questionnaire. The main outcomes were any anatomic site of fracture and fall-related fracture. Severe hypoglycemia was defined as an episode of hypoglycemia that required the assistance of others to achieve recovery.Results A total of 92 fractures occurred in 64 patients, and 59 fractures (64%) were fall-related. Only one participant experienced fracture within the 10 years following their diagnosis of diabetes. In logistic regression analysis, the multivariate-adjusted ORs (95% CIs) of a history of severe hypoglycemia were 2.11 (1.11 to 4.09) for any fracture and 1.91 (0.93 to 4.02) for fall-related fracture. Fourteen of 18 participants with multiple episodes of any type of fracture had a history of severe hypoglycemia (p<0.001 vs no fracture).Conclusions We have shown that a history of severe hypoglycemia is significantly associated with a higher risk of bone fracture in Japanese patients with T1D.https://drc.bmj.com/content/9/1/e002099.full |
| spellingShingle | Takanari Kitazono Yuji Komorita Yasutaka Maeda Masae Minami Rie Yoshioka Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetes BMJ Open Diabetes Research & Care |
| title | Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetes |
| title_full | Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetes |
| title_fullStr | Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetes |
| title_full_unstemmed | Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetes |
| title_short | Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetes |
| title_sort | prevalence of bone fracture and its association with severe hypoglycemia in japanese patients with type 1 diabetes |
| url | https://drc.bmj.com/content/9/1/e002099.full |
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