Glucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart
Abstract Background Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United States have diagnosed diabetes mellitus and around 80.8 million have impair...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12933-019-0948-4 |
| _version_ | 1818317729050918912 |
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| author | Marcello Ricardo Paulista Markus Susanne Rospleszcz Till Ittermann Sebastian Edgar Baumeister Sabine Schipf Ulrike Siewert-Markus Roberto Lorbeer Corinna Storz Violetta Ptushkina Annette Peters Christa Meisinger Fabian Bamberg Matthias Nauck Martin Bahls Henry Völzke Stephan Burkhard Felix Robin Bülow Wolfgang Rathmann Marcus Dörr |
| author_facet | Marcello Ricardo Paulista Markus Susanne Rospleszcz Till Ittermann Sebastian Edgar Baumeister Sabine Schipf Ulrike Siewert-Markus Roberto Lorbeer Corinna Storz Violetta Ptushkina Annette Peters Christa Meisinger Fabian Bamberg Matthias Nauck Martin Bahls Henry Völzke Stephan Burkhard Felix Robin Bülow Wolfgang Rathmann Marcus Dörr |
| author_sort | Marcello Ricardo Paulista Markus |
| collection | DOAJ |
| description | Abstract Background Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United States have diagnosed diabetes mellitus and around 80.8 million have impaired fasting glucose. We investigated the associations of fasting glucose (FG) and fasting insulin (FI), the homeostasis model assessment-insulin resistance index (HOMA-IR) and 2-h postload glucose (2HG) and insulin (2HI) with parameters of left ventricular geometry and function and arterial stiffness determined by magnetic resonance imaging in individuals without diagnosed type 2 diabetes. Methods Cross-sectional analyses of 1001 individuals (453 women, 45.3%), aged 21 to 80 years, from two independent population-based studies, the Study of Health in Pomerania (SHIP-TREND-0) and KORA FF4 Study. FG, FI, HOMA-IR, 2HG and 2HI, as well as glucose tolerance categories, were analyzed for associations with heart and arterial parameters using multivariable-adjusted linear regression models. Results In total, 390 individuals (39%) had prediabetes (isolated impaired fasting glucose, isolated glucose tolerance or both), and 49 (4.9%) were found to have unknown type 2 diabetes. In the multivariable-adjusted analysis, positive linear associations of FG, FI, HOMA-IR, 2HG and 2HI with arterial stiffness index and left ventricular wall-thickness and concentricity and inverse linear associations with left ventricular end-diastolic volume were observed. A 1 mmol/l higher FG was associated with a 1.18 ml/m2.7 (1.80 to 0.57; p < 0.001) lower left ventricular end-diastolic volume index, a 0.042 mm/m2.7 (0.014 to 0.070) higher left ventricular wall-thickness index, a 0.12 mmHg m2.7/ml (0.06 to 0.17; p < 0.001) greater arterial stiffness index and a 0.037 g/ml (0.018 to 0.056; p < 0.001) higher left ventricular concentricity. Conclusions Our findings suggest that higher glucose levels in the prediabetic range and insulin resistance might lead to higher arterial stiffness and concentric remodeling of the heart. |
| first_indexed | 2024-12-13T09:41:57Z |
| format | Article |
| id | doaj.art-89e5d4a2805d419594993759528e6f99 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-13T09:41:57Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-89e5d4a2805d419594993759528e6f992022-12-21T23:52:10ZengBMCCardiovascular Diabetology1475-28402019-11-0118111610.1186/s12933-019-0948-4Glucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heartMarcello Ricardo Paulista Markus0Susanne Rospleszcz1Till Ittermann2Sebastian Edgar Baumeister3Sabine Schipf4Ulrike Siewert-Markus5Roberto Lorbeer6Corinna Storz7Violetta Ptushkina8Annette Peters9Christa Meisinger10Fabian Bamberg11Matthias Nauck12Martin Bahls13Henry Völzke14Stephan Burkhard Felix15Robin Bülow16Wolfgang Rathmann17Marcus Dörr18Department of Internal Medicine B, University Medicine GreifswaldInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental HealthGerman Center for Diabetes Research (DZD), Partner Site GreifswaldChair of Epidemiology, Ludwig-Maximilians-Universität München at UNIKA-T AugsburgGerman Center for Diabetes Research (DZD), Partner Site GreifswaldInstitute for Medical Psychology, University Medicine GreifswaldDepartment of Radiology, Ludwig-Maximilians-University HospitalDepartment of Diagnostic and Interventional Radiology, University of TuebingenInstitute for Biometrics and Epidemiology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental HealthChair of Epidemiology, Ludwig-Maximilians-Universität München at UNIKA-T AugsburgDepartment of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Faculty of Medicine, University of FreiburgGerman Centre for Cardiovascular Research (DZHK), Partner Site GreifswaldDepartment of Internal Medicine B, University Medicine GreifswaldGerman Center for Diabetes Research (DZD), Partner Site GreifswaldDepartment of Internal Medicine B, University Medicine GreifswaldGerman Centre for Cardiovascular Research (DZHK), Partner Site GreifswaldInstitute for Biometrics and Epidemiology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDepartment of Internal Medicine B, University Medicine GreifswaldAbstract Background Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United States have diagnosed diabetes mellitus and around 80.8 million have impaired fasting glucose. We investigated the associations of fasting glucose (FG) and fasting insulin (FI), the homeostasis model assessment-insulin resistance index (HOMA-IR) and 2-h postload glucose (2HG) and insulin (2HI) with parameters of left ventricular geometry and function and arterial stiffness determined by magnetic resonance imaging in individuals without diagnosed type 2 diabetes. Methods Cross-sectional analyses of 1001 individuals (453 women, 45.3%), aged 21 to 80 years, from two independent population-based studies, the Study of Health in Pomerania (SHIP-TREND-0) and KORA FF4 Study. FG, FI, HOMA-IR, 2HG and 2HI, as well as glucose tolerance categories, were analyzed for associations with heart and arterial parameters using multivariable-adjusted linear regression models. Results In total, 390 individuals (39%) had prediabetes (isolated impaired fasting glucose, isolated glucose tolerance or both), and 49 (4.9%) were found to have unknown type 2 diabetes. In the multivariable-adjusted analysis, positive linear associations of FG, FI, HOMA-IR, 2HG and 2HI with arterial stiffness index and left ventricular wall-thickness and concentricity and inverse linear associations with left ventricular end-diastolic volume were observed. A 1 mmol/l higher FG was associated with a 1.18 ml/m2.7 (1.80 to 0.57; p < 0.001) lower left ventricular end-diastolic volume index, a 0.042 mm/m2.7 (0.014 to 0.070) higher left ventricular wall-thickness index, a 0.12 mmHg m2.7/ml (0.06 to 0.17; p < 0.001) greater arterial stiffness index and a 0.037 g/ml (0.018 to 0.056; p < 0.001) higher left ventricular concentricity. Conclusions Our findings suggest that higher glucose levels in the prediabetic range and insulin resistance might lead to higher arterial stiffness and concentric remodeling of the heart.http://link.springer.com/article/10.1186/s12933-019-0948-4Arterial stiffnessConcentric remodelingDiabetes mellitusInsulin resistancePrediabetes |
| spellingShingle | Marcello Ricardo Paulista Markus Susanne Rospleszcz Till Ittermann Sebastian Edgar Baumeister Sabine Schipf Ulrike Siewert-Markus Roberto Lorbeer Corinna Storz Violetta Ptushkina Annette Peters Christa Meisinger Fabian Bamberg Matthias Nauck Martin Bahls Henry Völzke Stephan Burkhard Felix Robin Bülow Wolfgang Rathmann Marcus Dörr Glucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart Cardiovascular Diabetology Arterial stiffness Concentric remodeling Diabetes mellitus Insulin resistance Prediabetes |
| title | Glucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart |
| title_full | Glucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart |
| title_fullStr | Glucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart |
| title_full_unstemmed | Glucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart |
| title_short | Glucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart |
| title_sort | glucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart |
| topic | Arterial stiffness Concentric remodeling Diabetes mellitus Insulin resistance Prediabetes |
| url | http://link.springer.com/article/10.1186/s12933-019-0948-4 |
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