Lipoic acid abates testis lead accumulation, sperm-endocrine deficits, testicular oxidative inflammation and apoptosis and modulates gene expression of Bax and Bcl-2 in rats

Lipoic acid abates testis lead accumulation, sperm-endocrine deficits, testicular oxidative inflammation and apoptosis and modulates gene expression of Bax and Bcl-2 in rats

The current study explored whether ALA could prevent testis Pb accumulation and Pb-induced oxidative testicular toxicity in rats. Adult male rats were randomly divided and administered ALA (25 mg/kg/day) and/or Pb (Pb acetate, 20 mg/kg/day) in Control group, ALA group, Pb group, and ALA + Pb group f...

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Bibliographic Details
Main Authors: Ademola C. Famurewa, Hamida Hamdi, Azza Sedky
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Scientific African
Subjects:
Testis
Alpha-lipoic acid
Bioaccumulation
Toxicity
Inflammation
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2468227623002983

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