miR-212-3p attenuates neuroinflammation of rats with Alzheimer's disease via regulating the SP1/BACE1/NLRP3/Caspase-1 signaling pathway

miR-212-3p attenuates neuroinflammation of rats with Alzheimer's disease via regulating the SP1/BACE1/NLRP3/Caspase-1 signaling pathway

Alzheimer's disease (AD) ranks as the leading cause of dementia. MicroRNA (miR)-212-3p has been identified to exert neuroprotective effects on brain disorders. The current study analyzed the protective role of miR-212-3p in AD rats via regulating the nucleotide-binding oligomerization domain-l...

Full description

Bibliographic Details
Main Authors:	Wei Nong, Chuanhong Bao, Yixin Chen, Zhiquan Wei
Format:	Article
Language:	English
Published:	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2022-07-01
Series:	Biomolecules & Biomedicine
Subjects:	Alzheimer's disease miR-212-3p SP1 BACE1 NLRP3/Caspase-1 signaling pathway pyroptosis
Online Access:	https://www.bjbms.org/ojs/index.php/bjbms/article/view/6723

Similar Items

Blockade of the NLRP3/caspase-1 axis attenuates ketamine-induced hippocampus pyroptosis and cognitive impairment in neonatal rats
by: Zhiheng Zhang, et al.
Published: (2021-10-01)

Policosanol ameliorates renal inflammation and pyroptosis in hypercholesterolemic rabbits via modulation of HMGB1/PI3K/mTOR/NLRP3/Caspase-1 pathway
by: Gehad M. Elnagar, et al.
Published: (2022-10-01)

NLRP3/Caspase-1-Mediated Pyroptosis of Astrocytes Induced by Antipsychotics Is Inhibited by a Histamine H1 Receptor-Selective Agonist
by: Meng He, et al.
Published: (2022-05-01)

Ticagrelor reduces doxorubicin-induced pyroptosis of rat cardiomyocytes by targeting GSK-3β/caspase-1
by: Shu-hui Wang, et al.
Published: (2023-01-01)

The Emerging Roles of the β-Secretase BACE1 and the Long Non-coding RNA BACE1-AS in Human Diseases: A Focus on Neurodegenerative Diseases and Cancer
by: Arezou Sayad, et al.
Published: (2022-03-01)

APAF1 Silencing Ameliorates Diabetic Retinopathy by Suppressing Inflammation, Oxidative Stress, and Caspase-3/GSDME-Dependent Pyroptosis
by: Ding Y, et al.
Published: (2024-04-01)

Development and Structural Modification of BACE1 Inhibitors
by: Ting Gu, et al.
Published: (2016-12-01)

Total extract of Abelmoschus manihot L. alleviates uric acid-induced renal tubular epithelial injury via inhibition of caspase-8/caspase-3/NLRP3/GSDME signaling
by: Zhihui Ding, et al.
Published: (2022-08-01)

Puerarin protects renal ischemia-reperfusion injury in rats through NLRP3/Caspase-1/GSDMD pathway
by: Kangyu Wang, et al.
Published: (2023-12-01)

Hydrogen Sulfide Attenuates Neuroinflammation by Inhibiting the NLRP3/Caspase-1/GSDMD Pathway in Retina or Brain Neuron following Rat Ischemia/Reperfusion
by: Kun-Li Yang, et al.
Published: (2022-09-01)

miR-155 inhibits chondrocyte pyroptosis in knee osteoarthritis by targeting SMAD2 and inhibiting the NLRP3/Caspase-1 pathway
by: Gen Li, et al.
Published: (2022-01-01)

Baicalin Alleviates Contrast-Induced Acute Kidney Injury Through ROS/NLRP3/Caspase-1/GSDMD Pathway-Mediated Proptosis in vitro
by: Li Y, et al.
Published: (2022-09-01)

Role of BACE1 in Alzheimer’s synaptic function
by: Brati Das, et al.
Published: (2017-08-01)

PS1 Affects the Pathology of Alzheimer’s Disease by Regulating BACE1 Distribution in the ER and BACE1 Maturation in the Golgi Apparatus
by: Nuomin Li, et al.
Published: (2022-12-01)

Mechanism of Electroacupuncture Against Cerebral Ischemia–Reperfusion Injury: Reducing Inflammatory Response and Cell Pyroptosis by Inhibiting NLRP3 and Caspase-1
by: Li Cai, et al.
Published: (2022-05-01)

BACE1 and SCD1 are associated with neurodegeneration
by: Ferley A. Bedoya-Guzmán, et al.
Published: (2023-09-01)

Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis
by: Yan Zu, et al.
Published: (2019-09-01)

A Tale of Two Drug Targets: The Evolutionary History of BACE1 and BACE2
by: Christopher eSouthan, et al.
Published: (2013-12-01)

Hydrogen Peroxide Is Crucial for NLRP3 Inflammasome-Mediated IL-1β Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells
by: Surabhi Surabhi, et al.
Published: (2021-08-01)

Salmonella and Caspase-1: a complex interplay of detection and evasion
by: Edward A Miao, et al.
Published: (2011-04-01)

NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury
by: Yuan Chang, et al.
Published: (2020-07-01)

Fibroblast growth factor 21 attenuates ventilator-induced lung injury by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway
by: Peng Ding, et al.
Published: (2023-05-01)

NEK7 Regulates NLRP3 Inflammasome Activation and Neuroinflammation Post-traumatic Brain Injury
by: Yuhua Chen, et al.
Published: (2019-08-01)

Dehydroisohispanolone as a Promising NLRP3 Inhibitor Agent: Bioevaluation and Molecular Docking
by: Laura González-Cofrade, et al.
Published: (2022-07-01)

Formononetin ameliorates airway inflammation by suppressing ESR1/NLRP3/Caspase-1 signaling in asthma
by: Liang Zhang, et al.
Published: (2023-12-01)

NLRP3/1-mediated pyroptosis: beneficial clues for the development of novel therapies for Alzheimer’s disease
by: Bo Hu, et al.
Published: (2024-01-01)

The p-STAT3/ANXA2 axis promotes caspase-1-mediated hepatocyte pyroptosis in non-alcoholic steatohepatitis
by: Yun Feng, et al.
Published: (2022-11-01)

Expression analysis of beta-secretase 1 (BACE1) enzyme in peripheral blood of patients with Alzheimer\'s disease
by: Alireza Vakilian, et al.
Published: (2019-06-01)

Corrigendum: NEK7 Regulates NLRP3 Inflammasome Activation and Neuroinflammation Post-traumatic Brain Injury
by: Yuhua Chen, et al.
Published: (2019-10-01)

Pyroptosis in NLRP3 inflammasome-related atherosclerosis
by: Xiang Zeng, et al.
Published: (2022-10-01)

Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer
by: Wei Xie, et al.
Published: (2023-11-01)

Benzyl Carbamates of 4-Aminosalicylanilides as Possible BACE1 Modulators
by: Petra Majerova, et al.
Published: (2022-11-01)

pHluorin-BACE1-mCherry Acts as a Reporter for the Intracellular Distribution of Active BACE1 In Vitro and In Vivo
by: Lu Zhao, et al.
Published: (2019-05-01)

β-sitosterol alleviates dextran sulfate sodium-induced experimental colitis via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis
by: Di Zhang, et al.
Published: (2023-10-01)

Mechanism of sodium butyrate, a metabolite of gut microbiota, regulating cardiac fibroblast transdifferentiation via the NLRP3/Caspase-1 pyroptosis pathway
by: Tiancheng Dong, et al.
Published: (2024-04-01)

Design, Synthesis and Evaluation of 3-(2-Aminoheterocycle)-4-benzyloxyphenylbenzamide Derivatives as BACE-1 Inhibitors
by: Lushan Yu, et al.
Published: (2013-03-01)

Caspase-1 Inhibitor Reduces Pyroptosis Induced by Brain Death in Kidney
by: Weifeng Liu, et al.
Published: (2021-11-01)

Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1
by: Anita A. Pinar, et al.
Published: (2020-08-01)

Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo
by: Wei Liu, et al.
Published: (2018-02-01)

Quercetin inhibits caspase-1-dependent macrophage pyroptosis in experimental folic acid nephropathy
by: Xianli Gao, et al.
Published: (2024-01-01)