Correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathy
Abstract Background Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes. DR involves a state of systemic inflammation, and chronic inflammation can promote microvascular and macrovascular diseases in diabetic patients and accelerate disease progression. Ultraw...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-022-02442-7 |
| _version_ | 1811250919485997056 |
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| author | Lili Huang Lele Li Min Wang Dongmei Zhang Yu Song |
| author_facet | Lili Huang Lele Li Min Wang Dongmei Zhang Yu Song |
| author_sort | Lili Huang |
| collection | DOAJ |
| description | Abstract Background Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes. DR involves a state of systemic inflammation, and chronic inflammation can promote microvascular and macrovascular diseases in diabetic patients and accelerate disease progression. Ultrawide-field FFA (UWFA) systems are increasingly being used to examine a wider retina. The aim of this study was to explore the correlation between the different manifestations of retinopathy under UWFA and the systemic indicators of white blood cells in patients with diabetic retinopathy. Methods This retrospective study included the hospitalized DR patients in the Department of Ophthalmology and Endocrinology of the Affiliated Hospital 2 of Nantong University between January 2016 and March 2019. This study examined the correlations between the UWFA examination results and glycated hemoglobin (HbA1c), routine blood tests,and the neutrophil-to-lymphocyte ratio of patients with clinically diagnosed DR during hospitalization. Results A total of 115 patients with DR (53 females and 62 males) were included (199 eyes: 102 right eyes and 97 left eyes). UWFA revealed that most eyes (77.4%) had grade 4 microvascular leakage, 52.8% had grade 0 capillary non-perfusion area, 59.3% had grade 0 neovascularization, and 92.0% had grade 0 fibrous proliferative membranes. Microvascular leakage was correlated with the NLR (r = 0.186, P = 0.027). Capillary non-perfusion area was correlated with the monocyte ratio (r = 0.144, P = 0.042) and the eosinophil ratio (r = 0.123, P = 0.044). Neovascularization was correlated to the monocyte ratio (r = 0.324, P = 0.018). Finally, the fibrous proliferative membrane was correlated to the monocyte ratio (r = 0.418, P = 0.002). Only the eosinophil ratio was independently associated with proliferative DR (odds ratio = 1.25, 95% confidence interval: 1.04–1.51, P = 0.018). Conclusion The results of UWFA imaging in patients with DR are correlated with white blood cell population indexes. The eosinophil ratio was independently associated with proliferative DR. |
| first_indexed | 2024-04-12T16:11:58Z |
| format | Article |
| id | doaj.art-89eac066c6c14e3da72c2a47dcc50c8c |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-12T16:11:58Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-89eac066c6c14e3da72c2a47dcc50c8c2022-12-22T03:25:52ZengBMCBMC Ophthalmology1471-24152022-05-012211810.1186/s12886-022-02442-7Correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathyLili Huang0Lele Li1Min Wang2Dongmei Zhang3Yu Song4Department of Ophthalmology, Affiliated Hospital 2 of Nantong UniversityDepartment of Ophthalmology, Affiliated Hospital 2 of Nantong UniversityDepartment of Ophthalmology, Affiliated Hospital 2 of Nantong UniversityMedical Research Center, Affiliated Hospital 2 of Nantong UniversityDepartment of Ophthalmology, Affiliated Hospital 2 of Nantong UniversityAbstract Background Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes. DR involves a state of systemic inflammation, and chronic inflammation can promote microvascular and macrovascular diseases in diabetic patients and accelerate disease progression. Ultrawide-field FFA (UWFA) systems are increasingly being used to examine a wider retina. The aim of this study was to explore the correlation between the different manifestations of retinopathy under UWFA and the systemic indicators of white blood cells in patients with diabetic retinopathy. Methods This retrospective study included the hospitalized DR patients in the Department of Ophthalmology and Endocrinology of the Affiliated Hospital 2 of Nantong University between January 2016 and March 2019. This study examined the correlations between the UWFA examination results and glycated hemoglobin (HbA1c), routine blood tests,and the neutrophil-to-lymphocyte ratio of patients with clinically diagnosed DR during hospitalization. Results A total of 115 patients with DR (53 females and 62 males) were included (199 eyes: 102 right eyes and 97 left eyes). UWFA revealed that most eyes (77.4%) had grade 4 microvascular leakage, 52.8% had grade 0 capillary non-perfusion area, 59.3% had grade 0 neovascularization, and 92.0% had grade 0 fibrous proliferative membranes. Microvascular leakage was correlated with the NLR (r = 0.186, P = 0.027). Capillary non-perfusion area was correlated with the monocyte ratio (r = 0.144, P = 0.042) and the eosinophil ratio (r = 0.123, P = 0.044). Neovascularization was correlated to the monocyte ratio (r = 0.324, P = 0.018). Finally, the fibrous proliferative membrane was correlated to the monocyte ratio (r = 0.418, P = 0.002). Only the eosinophil ratio was independently associated with proliferative DR (odds ratio = 1.25, 95% confidence interval: 1.04–1.51, P = 0.018). Conclusion The results of UWFA imaging in patients with DR are correlated with white blood cell population indexes. The eosinophil ratio was independently associated with proliferative DR.https://doi.org/10.1186/s12886-022-02442-7Diabetes mellitusDiabetic retinopathyFundus fluorescein angiographyInflammationNeutrophil-to-lymphocyte ratio |
| spellingShingle | Lili Huang Lele Li Min Wang Dongmei Zhang Yu Song Correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathy BMC Ophthalmology Diabetes mellitus Diabetic retinopathy Fundus fluorescein angiography Inflammation Neutrophil-to-lymphocyte ratio |
| title | Correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathy |
| title_full | Correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathy |
| title_fullStr | Correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathy |
| title_full_unstemmed | Correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathy |
| title_short | Correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathy |
| title_sort | correlation between ultrawide field fluorescence contrast results and white blood cell indexes in diabetic retinopathy |
| topic | Diabetes mellitus Diabetic retinopathy Fundus fluorescein angiography Inflammation Neutrophil-to-lymphocyte ratio |
| url | https://doi.org/10.1186/s12886-022-02442-7 |
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