ß-Adrenoreceptors in Human Cancers
Cancer is the leading cause of death and represents a significant economic burden worldwide. The numbers are constantly growing as a result of increasing life expectancy, toxic environmental factors, and adoption of Western lifestyle. Among lifestyle factors, stress and the related signaling pathway...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/4/3671 |
| _version_ | 1797620480117571584 |
|---|---|
| author | Zoltan Kraboth Bernadette Kalman |
| author_facet | Zoltan Kraboth Bernadette Kalman |
| author_sort | Zoltan Kraboth |
| collection | DOAJ |
| description | Cancer is the leading cause of death and represents a significant economic burden worldwide. The numbers are constantly growing as a result of increasing life expectancy, toxic environmental factors, and adoption of Western lifestyle. Among lifestyle factors, stress and the related signaling pathways have recently been implicated in the development of tumors. Here we present some epidemiological and preclinical data concerning stress-related activation of the ß-adrenoreceptors (ß-ARs), which contributes to the formation, sequential transformation, and migration of different tumor cell types. We focused our survey on research results for breast and lung cancer, melanoma, and gliomas published in the past five years. Based on the converging evidence, we present a conceptual framework of how cancer cells hijack a physiological mechanism involving ß-ARs toward a positive modulation of their own survival. In addition, we also highlight the potential contribution of ß-AR activation to tumorigenesis and metastasis formation. Finally, we outline the antitumor effects of targeting the ß-adrenergic signaling pathways, methods for which primarily include repurposed ß-blocker drugs. However, we also call attention to the emerging (though as yet largely explorative) method of chemogenetics, which has a great potential in suppressing tumor growth either by selectively modulating neuronal cell groups involved in stress responses affecting cancer cells or by directly manipulating specific (e.g., the ß-AR) receptors on a tumor and its microenvironment. |
| first_indexed | 2024-03-11T08:43:04Z |
| format | Article |
| id | doaj.art-89ed1bbf84a94425bf60439709f2ffd9 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:43:04Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-89ed1bbf84a94425bf60439709f2ffd92023-11-16T21:03:20ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244367110.3390/ijms24043671ß-Adrenoreceptors in Human CancersZoltan Kraboth0Bernadette Kalman1Department of Pathology, School of Medicine, University of Pécs, 12. Sziget Street, 7624 Pécs, HungarySzentagothai Research Center, University of Pécs, 20. Ifjusag Street, 7624 Pécs, HungaryCancer is the leading cause of death and represents a significant economic burden worldwide. The numbers are constantly growing as a result of increasing life expectancy, toxic environmental factors, and adoption of Western lifestyle. Among lifestyle factors, stress and the related signaling pathways have recently been implicated in the development of tumors. Here we present some epidemiological and preclinical data concerning stress-related activation of the ß-adrenoreceptors (ß-ARs), which contributes to the formation, sequential transformation, and migration of different tumor cell types. We focused our survey on research results for breast and lung cancer, melanoma, and gliomas published in the past five years. Based on the converging evidence, we present a conceptual framework of how cancer cells hijack a physiological mechanism involving ß-ARs toward a positive modulation of their own survival. In addition, we also highlight the potential contribution of ß-AR activation to tumorigenesis and metastasis formation. Finally, we outline the antitumor effects of targeting the ß-adrenergic signaling pathways, methods for which primarily include repurposed ß-blocker drugs. However, we also call attention to the emerging (though as yet largely explorative) method of chemogenetics, which has a great potential in suppressing tumor growth either by selectively modulating neuronal cell groups involved in stress responses affecting cancer cells or by directly manipulating specific (e.g., the ß-AR) receptors on a tumor and its microenvironment.https://www.mdpi.com/1422-0067/24/4/3671ß-adrenoreceptorsadrenergic signalingß-blockerscancerstressphysiological pathways hijacked by cancer |
| spellingShingle | Zoltan Kraboth Bernadette Kalman ß-Adrenoreceptors in Human Cancers International Journal of Molecular Sciences ß-adrenoreceptors adrenergic signaling ß-blockers cancer stress physiological pathways hijacked by cancer |
| title | ß-Adrenoreceptors in Human Cancers |
| title_full | ß-Adrenoreceptors in Human Cancers |
| title_fullStr | ß-Adrenoreceptors in Human Cancers |
| title_full_unstemmed | ß-Adrenoreceptors in Human Cancers |
| title_short | ß-Adrenoreceptors in Human Cancers |
| title_sort | ss adrenoreceptors in human cancers |
| topic | ß-adrenoreceptors adrenergic signaling ß-blockers cancer stress physiological pathways hijacked by cancer |
| url | https://www.mdpi.com/1422-0067/24/4/3671 |
| work_keys_str_mv | AT zoltankraboth ßadrenoreceptorsinhumancancers AT bernadettekalman ßadrenoreceptorsinhumancancers |