Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia
Dietary calcium intake is a modifiable, lifestyle factor that can affect bone health and the risk of fracture. The diurnal rhythm of bone remodelling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of daily, bed-time ingestion of a calcium-fortified,...
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MDPI AG
2022-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/17/3486 |
| _version_ | 1797493858019311616 |
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| author | Catherine Norton Manjula Hettiarachchi Rachel Cooke Marta Kozior Hilkka Kontro Rosemary Daniel Philip Jakeman |
| author_facet | Catherine Norton Manjula Hettiarachchi Rachel Cooke Marta Kozior Hilkka Kontro Rosemary Daniel Philip Jakeman |
| author_sort | Catherine Norton |
| collection | DOAJ |
| description | Dietary calcium intake is a modifiable, lifestyle factor that can affect bone health and the risk of fracture. The diurnal rhythm of bone remodelling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of daily, bed-time ingestion of a calcium-fortified, milk-derived protein matrix (MBPM) or control (CON), for 24 weeks, on serum biomarkers of bone resorption (C-terminal telopeptide of type I collagen, CTX) and formation (serum pro-collagen type 1 N-terminal propeptide, P1NP), and site-specific aerial bone mineral density (BMD), trabecular bone score (TBS), in postmenopausal women with osteopenia. The MBPM supplement increased mean daily energy, protein, and calcium intake, by 11, 30, and 107%, respectively. 24-week supplementation with MBPM decreased CTX by 23%, from 0.547 (0.107) to 0.416 (0.087) ng/mL (<i>p</i> < 0.001) and P1NP by 17%, from 60.6 (9.1) to 49.7 (7.2) μg/L (<i>p</i> < 0.001). Compared to CON, MBPM induced a significantly greater reduction in serum CTX (mean (CI<sub>95%</sub>); −9 (8.6) vs. −23 (8.5)%, <i>p</i> = 0.025 but not P1NP −19 (8.8) vs. −17 (5.2)%, <i>p</i> = 0.802). No significant change in TBS, AP spine or dual femur aerial BMD was observed for CON or MBPM. This study demonstrates the potential benefit of bed-time ingestion of a calcium-fortified, milk-based protein matrix on homeostatic bone remodelling but no resultant treatment effect on site-specific BMD in postmenopausal women with osteopenia. |
| first_indexed | 2024-03-10T01:26:00Z |
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| id | doaj.art-89ed74c1e9e04121946db061ca55db71 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T01:26:00Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-89ed74c1e9e04121946db061ca55db712023-11-23T13:51:15ZengMDPI AGNutrients2072-66432022-08-011417348610.3390/nu14173486Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with OsteopeniaCatherine Norton0Manjula Hettiarachchi1Rachel Cooke2Marta Kozior3Hilkka Kontro4Rosemary Daniel5Philip Jakeman6Health Research Institute and Department of Physical Education and Sport Sciences, University of Limerick, V94 T9PX Limerick, IrelandHealth Research Institute and Department of Physical Education and Sport Sciences, University of Limerick, V94 T9PX Limerick, IrelandHealth Research Institute and Department of Physical Education and Sport Sciences, University of Limerick, V94 T9PX Limerick, IrelandHealth Research Institute and Department of Physical Education and Sport Sciences, University of Limerick, V94 T9PX Limerick, IrelandHealth Research Institute and Department of Physical Education and Sport Sciences, University of Limerick, V94 T9PX Limerick, IrelandHealth Research Institute and Department of Physical Education and Sport Sciences, University of Limerick, V94 T9PX Limerick, IrelandHealth Research Institute and Department of Physical Education and Sport Sciences, University of Limerick, V94 T9PX Limerick, IrelandDietary calcium intake is a modifiable, lifestyle factor that can affect bone health and the risk of fracture. The diurnal rhythm of bone remodelling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of daily, bed-time ingestion of a calcium-fortified, milk-derived protein matrix (MBPM) or control (CON), for 24 weeks, on serum biomarkers of bone resorption (C-terminal telopeptide of type I collagen, CTX) and formation (serum pro-collagen type 1 N-terminal propeptide, P1NP), and site-specific aerial bone mineral density (BMD), trabecular bone score (TBS), in postmenopausal women with osteopenia. The MBPM supplement increased mean daily energy, protein, and calcium intake, by 11, 30, and 107%, respectively. 24-week supplementation with MBPM decreased CTX by 23%, from 0.547 (0.107) to 0.416 (0.087) ng/mL (<i>p</i> < 0.001) and P1NP by 17%, from 60.6 (9.1) to 49.7 (7.2) μg/L (<i>p</i> < 0.001). Compared to CON, MBPM induced a significantly greater reduction in serum CTX (mean (CI<sub>95%</sub>); −9 (8.6) vs. −23 (8.5)%, <i>p</i> = 0.025 but not P1NP −19 (8.8) vs. −17 (5.2)%, <i>p</i> = 0.802). No significant change in TBS, AP spine or dual femur aerial BMD was observed for CON or MBPM. This study demonstrates the potential benefit of bed-time ingestion of a calcium-fortified, milk-based protein matrix on homeostatic bone remodelling but no resultant treatment effect on site-specific BMD in postmenopausal women with osteopenia.https://www.mdpi.com/2072-6643/14/17/3486randomized control trialmilk protein matrixnutrient interventionnutrient timingbone remodellingbone turnover markers |
| spellingShingle | Catherine Norton Manjula Hettiarachchi Rachel Cooke Marta Kozior Hilkka Kontro Rosemary Daniel Philip Jakeman Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia Nutrients randomized control trial milk protein matrix nutrient intervention nutrient timing bone remodelling bone turnover markers |
| title | Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia |
| title_full | Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia |
| title_fullStr | Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia |
| title_full_unstemmed | Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia |
| title_short | Effect of 24-Week, Late-Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix on Biomarkers of Bone Metabolism and Site-Specific Bone Mineral Density in Postmenopausal Women with Osteopenia |
| title_sort | effect of 24 week late evening ingestion of a calcium fortified milk based protein matrix on biomarkers of bone metabolism and site specific bone mineral density in postmenopausal women with osteopenia |
| topic | randomized control trial milk protein matrix nutrient intervention nutrient timing bone remodelling bone turnover markers |
| url | https://www.mdpi.com/2072-6643/14/17/3486 |
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