| Summary: | Six benzophenone derivatives, carneusones A-F (<b>1</b>–<b>6</b>), along with seven known compounds (<b>7</b>–<b>13</b>) were isolated from a strain of sponge-derived marine fungus <i>Aspergillus carneus</i> GXIMD00543. Their chemical structures were elucidated by detailed spectroscopic data and quantum chemical calculations. Compounds <b>5</b>, <b>6</b>, and <b>8</b> exhibited moderate anti-inflammatory activity on NO secretion using lipopolysaccharide (LPS)-induced RAW 264.7 cells with EC<sub>50</sub> values of 34.6 ± 0.9, 20.2 ± 1.8, and 26.8 ± 1.7 μM, while <b>11</b> showed potent effect with an EC<sub>50</sub> value of 2.9 ± 0.1 μM.
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