Carneusones A-F, Benzophenone Derivatives from Sponge-Derived Fungus <i>Aspergillus carneus</i> GXIMD00543
Six benzophenone derivatives, carneusones A-F (<b>1</b>–<b>6</b>), along with seven known compounds (<b>7</b>–<b>13</b>) were isolated from a strain of sponge-derived marine fungus <i>Aspergillus carneus</i> GXIMD00543. Their chemical struc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/22/2/63 |
| _version_ | 1797297631691538432 |
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| author | Chun-Ju Lu Li-Fen Liang Geng-Si Zhang Hai-Yan Li Chun-Qing Fu Qin Yu Dong-Mei Zhou Zhi-Wei Su Kai Liu Cheng-Hai Gao Xin-Ya Xu Yong-Hong Liu |
| author_facet | Chun-Ju Lu Li-Fen Liang Geng-Si Zhang Hai-Yan Li Chun-Qing Fu Qin Yu Dong-Mei Zhou Zhi-Wei Su Kai Liu Cheng-Hai Gao Xin-Ya Xu Yong-Hong Liu |
| author_sort | Chun-Ju Lu |
| collection | DOAJ |
| description | Six benzophenone derivatives, carneusones A-F (<b>1</b>–<b>6</b>), along with seven known compounds (<b>7</b>–<b>13</b>) were isolated from a strain of sponge-derived marine fungus <i>Aspergillus carneus</i> GXIMD00543. Their chemical structures were elucidated by detailed spectroscopic data and quantum chemical calculations. Compounds <b>5</b>, <b>6</b>, and <b>8</b> exhibited moderate anti-inflammatory activity on NO secretion using lipopolysaccharide (LPS)-induced RAW 264.7 cells with EC<sub>50</sub> values of 34.6 ± 0.9, 20.2 ± 1.8, and 26.8 ± 1.7 μM, while <b>11</b> showed potent effect with an EC<sub>50</sub> value of 2.9 ± 0.1 μM. |
| first_indexed | 2024-03-07T22:23:53Z |
| format | Article |
| id | doaj.art-89f04360679141a888e3cc95a4c0d885 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-07T22:23:53Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-89f04360679141a888e3cc95a4c0d8852024-02-23T15:25:13ZengMDPI AGMarine Drugs1660-33972024-01-012226310.3390/md22020063Carneusones A-F, Benzophenone Derivatives from Sponge-Derived Fungus <i>Aspergillus carneus</i> GXIMD00543Chun-Ju Lu0Li-Fen Liang1Geng-Si Zhang2Hai-Yan Li3Chun-Qing Fu4Qin Yu5Dong-Mei Zhou6Zhi-Wei Su7Kai Liu8Cheng-Hai Gao9Xin-Ya Xu10Yong-Hong Liu11Guangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaGuangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaGuangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaGuangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaGuangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaGuangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaGuangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaGuangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaGuangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaGuangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaGuangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaGuangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaSix benzophenone derivatives, carneusones A-F (<b>1</b>–<b>6</b>), along with seven known compounds (<b>7</b>–<b>13</b>) were isolated from a strain of sponge-derived marine fungus <i>Aspergillus carneus</i> GXIMD00543. Their chemical structures were elucidated by detailed spectroscopic data and quantum chemical calculations. Compounds <b>5</b>, <b>6</b>, and <b>8</b> exhibited moderate anti-inflammatory activity on NO secretion using lipopolysaccharide (LPS)-induced RAW 264.7 cells with EC<sub>50</sub> values of 34.6 ± 0.9, 20.2 ± 1.8, and 26.8 ± 1.7 μM, while <b>11</b> showed potent effect with an EC<sub>50</sub> value of 2.9 ± 0.1 μM.https://www.mdpi.com/1660-3397/22/2/63marine fungusanti-inflammatory activity<i>Aspergillus carneus</i>benzophenoneBeibu gulf |
| spellingShingle | Chun-Ju Lu Li-Fen Liang Geng-Si Zhang Hai-Yan Li Chun-Qing Fu Qin Yu Dong-Mei Zhou Zhi-Wei Su Kai Liu Cheng-Hai Gao Xin-Ya Xu Yong-Hong Liu Carneusones A-F, Benzophenone Derivatives from Sponge-Derived Fungus <i>Aspergillus carneus</i> GXIMD00543 Marine Drugs marine fungus anti-inflammatory activity <i>Aspergillus carneus</i> benzophenone Beibu gulf |
| title | Carneusones A-F, Benzophenone Derivatives from Sponge-Derived Fungus <i>Aspergillus carneus</i> GXIMD00543 |
| title_full | Carneusones A-F, Benzophenone Derivatives from Sponge-Derived Fungus <i>Aspergillus carneus</i> GXIMD00543 |
| title_fullStr | Carneusones A-F, Benzophenone Derivatives from Sponge-Derived Fungus <i>Aspergillus carneus</i> GXIMD00543 |
| title_full_unstemmed | Carneusones A-F, Benzophenone Derivatives from Sponge-Derived Fungus <i>Aspergillus carneus</i> GXIMD00543 |
| title_short | Carneusones A-F, Benzophenone Derivatives from Sponge-Derived Fungus <i>Aspergillus carneus</i> GXIMD00543 |
| title_sort | carneusones a f benzophenone derivatives from sponge derived fungus i aspergillus carneus i gximd00543 |
| topic | marine fungus anti-inflammatory activity <i>Aspergillus carneus</i> benzophenone Beibu gulf |
| url | https://www.mdpi.com/1660-3397/22/2/63 |
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