Early divergent host responses in SHIVsf162P3 and SIVmac251 infected macaques correlate with control of viremia.
We previously showed intravaginal inoculation with SHIVsf162p3 results in transient viremia followed by undetectable viremia in most macaques, and some displayed subsequent immunity to superinfection with pathogenic SIVmac251. Here we compare early T cell activation, proliferation, and plasma cytoki...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-03-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3064595?pdf=render |
| _version_ | 1819152977641865216 |
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| author | Huanbin Xu Xiaolei Wang Lisa A Morici Bapi Pahar Ronald S Veazey |
| author_facet | Huanbin Xu Xiaolei Wang Lisa A Morici Bapi Pahar Ronald S Veazey |
| author_sort | Huanbin Xu |
| collection | DOAJ |
| description | We previously showed intravaginal inoculation with SHIVsf162p3 results in transient viremia followed by undetectable viremia in most macaques, and some displayed subsequent immunity to superinfection with pathogenic SIVmac251. Here we compare early T cell activation, proliferation, and plasma cytokine/chemokine responses in macaques intravaginally infected with either SHIVsf162p3 or SIVmac251 to determine whether distinct differences in host responses may be associated with early viral containment. The data show SIVmac251 infection results in significantly higher levels of T cell activation, proliferation, and a mixed cytokine/chemokine "storm" in plasma in primary infection, whereas infection with SHIVsf162p3 resulted in significantly lower levels of T cell activation, proliferation, and better preservation of memory CD4+ T cells in early infection which immediately preceded control of viremia. These results support the hypothesis that early systemic immune activation, T cell proliferation, and a more prominent and broader array of cytokine/chemokine responses facilitate SIV replication, and may play a key role in persistence of infection, and the progression to AIDS. In contrast, immune unresponsiveness may be associated with eventual clearance of virus, a concept that may have key significance for therapy and vaccine design. |
| first_indexed | 2024-12-22T14:57:52Z |
| format | Article |
| id | doaj.art-89f06f69bc094538a2a43b726f056819 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T14:57:52Z |
| publishDate | 2011-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-89f06f69bc094538a2a43b726f0568192022-12-21T18:22:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-03-0163e1796510.1371/journal.pone.0017965Early divergent host responses in SHIVsf162P3 and SIVmac251 infected macaques correlate with control of viremia.Huanbin XuXiaolei WangLisa A MoriciBapi PaharRonald S VeazeyWe previously showed intravaginal inoculation with SHIVsf162p3 results in transient viremia followed by undetectable viremia in most macaques, and some displayed subsequent immunity to superinfection with pathogenic SIVmac251. Here we compare early T cell activation, proliferation, and plasma cytokine/chemokine responses in macaques intravaginally infected with either SHIVsf162p3 or SIVmac251 to determine whether distinct differences in host responses may be associated with early viral containment. The data show SIVmac251 infection results in significantly higher levels of T cell activation, proliferation, and a mixed cytokine/chemokine "storm" in plasma in primary infection, whereas infection with SHIVsf162p3 resulted in significantly lower levels of T cell activation, proliferation, and better preservation of memory CD4+ T cells in early infection which immediately preceded control of viremia. These results support the hypothesis that early systemic immune activation, T cell proliferation, and a more prominent and broader array of cytokine/chemokine responses facilitate SIV replication, and may play a key role in persistence of infection, and the progression to AIDS. In contrast, immune unresponsiveness may be associated with eventual clearance of virus, a concept that may have key significance for therapy and vaccine design.http://europepmc.org/articles/PMC3064595?pdf=render |
| spellingShingle | Huanbin Xu Xiaolei Wang Lisa A Morici Bapi Pahar Ronald S Veazey Early divergent host responses in SHIVsf162P3 and SIVmac251 infected macaques correlate with control of viremia. PLoS ONE |
| title | Early divergent host responses in SHIVsf162P3 and SIVmac251 infected macaques correlate with control of viremia. |
| title_full | Early divergent host responses in SHIVsf162P3 and SIVmac251 infected macaques correlate with control of viremia. |
| title_fullStr | Early divergent host responses in SHIVsf162P3 and SIVmac251 infected macaques correlate with control of viremia. |
| title_full_unstemmed | Early divergent host responses in SHIVsf162P3 and SIVmac251 infected macaques correlate with control of viremia. |
| title_short | Early divergent host responses in SHIVsf162P3 and SIVmac251 infected macaques correlate with control of viremia. |
| title_sort | early divergent host responses in shivsf162p3 and sivmac251 infected macaques correlate with control of viremia |
| url | http://europepmc.org/articles/PMC3064595?pdf=render |
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