Methotrexate enhances 5-aminolevulinic acid-mediated photodynamic therapy-induced killing of human SCC4 cells by upregulation of coproporphyrinogen oxidase

Methotrexate enhances 5-aminolevulinic acid-mediated photodynamic therapy-induced killing of human SCC4 cells by upregulation of coproporphyrinogen oxidase

Topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is effective for treatment of oral precancerous and cancerous lesions. This in vitro study tried to examine whether the SCC4 cell killing by ALA-PDT was enhanced by pretreatment of methotrexate (MTX). Methods: To measure the SCC4...

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Bibliographic Details
Main Authors:	Deng-Fu Yang, Jeng-Woei Lee, Hsin-Ming Chen, Zheng Huang, Yih-Chih Hsu
Format:	Article
Language:	English
Published:	Elsevier 2014-02-01
Series:	Journal of the Formosan Medical Association
Subjects:	5-aminolevulinic acid coproporphyrinogen oxidase ferrochelatase human squamous cell carcinoma 4 cell methotrexate photodynamic therapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S092966461300452X

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