Segregation analysis of apolipoprotein A1 levels in families of adolescents: A community-based study in Taiwan
<p/> <p>Background</p> <p>Apolipoprotein (Apo) A1 is a protective factor for cardiovascular events. This study aimed to perform complex segregation analyses of Apo A1 levels in families of adolescents systematically ascertained from the junior high school students in a rural...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2006-01-01
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| Series: | BMC Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2156/7/4 |
| _version_ | 1811336828469379072 |
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| author | Su Ta-Chen Hsu Hsiu-Ching Chen Wei J Chien Kuo-Liong Chen Ming-Fong Lee Yuan-Teh |
| author_facet | Su Ta-Chen Hsu Hsiu-Ching Chen Wei J Chien Kuo-Liong Chen Ming-Fong Lee Yuan-Teh |
| author_sort | Su Ta-Chen |
| collection | DOAJ |
| description | <p/> <p>Background</p> <p>Apolipoprotein (Apo) A1 is a protective factor for cardiovascular events. This study aimed to perform complex segregation analyses of Apo A1 levels in families of adolescents systematically ascertained from the junior high school students in a rural community. Both siblings and parents of the adolescent probands were recruited for the study. Apo A1 concentrations were measured by turbidimetric immunoassay methods. After adjustment for gender, age, body mass index, smoking and drinking status, residual values of Apo A1 were subjected to subsequent analyses.</p> <p>Results</p> <p>Significant mother-father and parent-offspring correlations were found. Commingling analyses indicated that a four-component distribution model was needed to account for the Apo A1 variation. Segregation analysis using regressive models revealed that the best-fit model of Apo A1 was a model of environmental effect plus familial correlation (heritability = 23.9%), in which a significant mother-father correlation existed. Models containing major gene effect could be rejected.</p> <p>Conclusion</p> <p>These results suggest that variations of Apo A1 levels in the normal range, especially during adolescence, are likely to be influenced by multiple factors without significant contribution from major genes.</p> |
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| institution | Directory Open Access Journal |
| issn | 1471-2156 |
| language | English |
| last_indexed | 2024-04-13T17:46:12Z |
| publishDate | 2006-01-01 |
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| spelling | doaj.art-89f57bc651554e5cb3df6da87b9c35d32022-12-22T02:36:59ZengBMCBMC Genetics1471-21562006-01-0171410.1186/1471-2156-7-4Segregation analysis of apolipoprotein A1 levels in families of adolescents: A community-based study in TaiwanSu Ta-ChenHsu Hsiu-ChingChen Wei JChien Kuo-LiongChen Ming-FongLee Yuan-Teh<p/> <p>Background</p> <p>Apolipoprotein (Apo) A1 is a protective factor for cardiovascular events. This study aimed to perform complex segregation analyses of Apo A1 levels in families of adolescents systematically ascertained from the junior high school students in a rural community. Both siblings and parents of the adolescent probands were recruited for the study. Apo A1 concentrations were measured by turbidimetric immunoassay methods. After adjustment for gender, age, body mass index, smoking and drinking status, residual values of Apo A1 were subjected to subsequent analyses.</p> <p>Results</p> <p>Significant mother-father and parent-offspring correlations were found. Commingling analyses indicated that a four-component distribution model was needed to account for the Apo A1 variation. Segregation analysis using regressive models revealed that the best-fit model of Apo A1 was a model of environmental effect plus familial correlation (heritability = 23.9%), in which a significant mother-father correlation existed. Models containing major gene effect could be rejected.</p> <p>Conclusion</p> <p>These results suggest that variations of Apo A1 levels in the normal range, especially during adolescence, are likely to be influenced by multiple factors without significant contribution from major genes.</p>http://www.biomedcentral.com/1471-2156/7/4 |
| spellingShingle | Su Ta-Chen Hsu Hsiu-Ching Chen Wei J Chien Kuo-Liong Chen Ming-Fong Lee Yuan-Teh Segregation analysis of apolipoprotein A1 levels in families of adolescents: A community-based study in Taiwan BMC Genetics |
| title | Segregation analysis of apolipoprotein A1 levels in families of adolescents: A community-based study in Taiwan |
| title_full | Segregation analysis of apolipoprotein A1 levels in families of adolescents: A community-based study in Taiwan |
| title_fullStr | Segregation analysis of apolipoprotein A1 levels in families of adolescents: A community-based study in Taiwan |
| title_full_unstemmed | Segregation analysis of apolipoprotein A1 levels in families of adolescents: A community-based study in Taiwan |
| title_short | Segregation analysis of apolipoprotein A1 levels in families of adolescents: A community-based study in Taiwan |
| title_sort | segregation analysis of apolipoprotein a1 levels in families of adolescents a community based study in taiwan |
| url | http://www.biomedcentral.com/1471-2156/7/4 |
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