The efficacy of Levetiracetam compared to Phenytoin in prevention of post-traumatic seizures
Objectives: To compare the efficacy of Levetiracetam (LEV) versus Phenytoin (PHY) in the prevention of post-traumatic seizures in a low-middle-income country. Materials and Methods: A prospective cohort study was conducted from 25th December 2021 to 24th June 2022 at the Pakistan Institute of Med...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
London Academic Publishing
2023-12-01
|
| Series: | Romanian Neurosurgery |
| Subjects: | |
| Online Access: | http://journals.lapub.co.uk/index.php/roneurosurgery/article/view/2481 |
| Summary: | Objectives: To compare the efficacy of Levetiracetam (LEV) versus Phenytoin (PHY) in the prevention of post-traumatic seizures in a low-middle-income country.
Materials and Methods: A prospective cohort study was conducted from 25th December 2021 to 24th June 2022 at the Pakistan Institute of Medical Sciences, Islamabad, Pakistan. A total of 140 patients presented with traumatic brain injury, both male and female, aged between 15 to 60 years were included. Patients with a history of epilepsy, acromegaly or hypogonadism, history of brain tumour or abscess were excluded. LEV was given to group A patients as a 1000 mg intravenous (IV) loading dose, followed by a dose of 500-1000 mg (orally) twice daily. PHY was given to group B patients as an IV loading dose of 15-20 mg/kg, followed by an oral dose of 4-8 mg/kg divided into three doses per day. All the patients were followed and the efficacy of the drugs was noted.
Results: The mean age of patients in groups A and B was 43.69 ± 9.05 SD years and 43.07 ± 9.46 SD years, respectively. The majority of the patients i.e., 108 (77.1%) were between the ages of 41 to 60 years. Out of the total 140 patients, 87 (62.1%) were males and 53 (37.9%) were females with male to female ratio of 1.6:1. LEV had an efficacy of 63 (90%) and PHY had an efficacy of 46 (65.7%) in this study, both having a p-value of 0.0005.
Conclusion: According to the results of this study, LEV is superior to PHY at preventing post-traumatic seizures.
|
|---|---|
| ISSN: | 1220-8841 2344-4959 |