Collective cell mechanics of epithelial shells with organoid-like morphologies

The physical origins of man-made tissue morphologies with organ-like microscopic anatomy and functionality remain poorly understood. Here, authors propose a mechanistic theory of these structures, employing a 3D vertex model to reproduce the characteristic morphologies such as branched shapes.

Bibliographic Details
Main Authors: Jan Rozman, Matej Krajnc, Primož Ziherl
Format: Article
Language:English
Published: Nature Portfolio 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17535-4
_version_ 1819200353038499840
author Jan Rozman
Matej Krajnc
Primož Ziherl
author_facet Jan Rozman
Matej Krajnc
Primož Ziherl
author_sort Jan Rozman
collection DOAJ
description The physical origins of man-made tissue morphologies with organ-like microscopic anatomy and functionality remain poorly understood. Here, authors propose a mechanistic theory of these structures, employing a 3D vertex model to reproduce the characteristic morphologies such as branched shapes.
first_indexed 2024-12-23T03:30:53Z
format Article
id doaj.art-89f72efd68ce42ac98995d4580317551
institution Directory Open Access Journal
issn 2041-1723
language English
last_indexed 2024-12-23T03:30:53Z
publishDate 2020-07-01
publisher Nature Portfolio
record_format Article
series Nature Communications
spelling doaj.art-89f72efd68ce42ac98995d45803175512022-12-21T18:01:42ZengNature PortfolioNature Communications2041-17232020-07-011111910.1038/s41467-020-17535-4Collective cell mechanics of epithelial shells with organoid-like morphologiesJan Rozman0Matej Krajnc1Primož Ziherl2Jožef Stefan InstituteJožef Stefan InstituteJožef Stefan InstituteThe physical origins of man-made tissue morphologies with organ-like microscopic anatomy and functionality remain poorly understood. Here, authors propose a mechanistic theory of these structures, employing a 3D vertex model to reproduce the characteristic morphologies such as branched shapes.https://doi.org/10.1038/s41467-020-17535-4
spellingShingle Jan Rozman
Matej Krajnc
Primož Ziherl
Collective cell mechanics of epithelial shells with organoid-like morphologies
Nature Communications
title Collective cell mechanics of epithelial shells with organoid-like morphologies
title_full Collective cell mechanics of epithelial shells with organoid-like morphologies
title_fullStr Collective cell mechanics of epithelial shells with organoid-like morphologies
title_full_unstemmed Collective cell mechanics of epithelial shells with organoid-like morphologies
title_short Collective cell mechanics of epithelial shells with organoid-like morphologies
title_sort collective cell mechanics of epithelial shells with organoid like morphologies
url https://doi.org/10.1038/s41467-020-17535-4
work_keys_str_mv AT janrozman collectivecellmechanicsofepithelialshellswithorganoidlikemorphologies
AT matejkrajnc collectivecellmechanicsofepithelialshellswithorganoidlikemorphologies
AT primozziherl collectivecellmechanicsofepithelialshellswithorganoidlikemorphologies