Antiviral therapy of chronic hepatitis C complicated by systemic cryoglobulinemic vasculitis
Literature analysis of published data on mechanisms of infection, disease progression and treatment of chronic hepatitis C, associated with systemic cryoglobulinemic vasculitis and kidney involvement is presented. A clinical case of effective treatment of cryoglobulinemic vasculitis associated with...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2016-07-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/477 |
| _version_ | 1826557910118825984 |
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| author | N. V. Dunaeva V. E. Karev O. A. Vorobyeva A. V. Mazing S. V. Lapin A. V. Smirnov D. A. Gusev |
| author_facet | N. V. Dunaeva V. E. Karev O. A. Vorobyeva A. V. Mazing S. V. Lapin A. V. Smirnov D. A. Gusev |
| author_sort | N. V. Dunaeva |
| collection | DOAJ |
| description | Literature analysis of published data on mechanisms of infection, disease progression and treatment of chronic hepatitis C, associated with systemic cryoglobulinemic vasculitis and kidney involvement is presented. A clinical case of effective treatment of cryoglobulinemic vasculitis associated with HCV infection is described. Female with HCV infection genotype 1b with liver fibrosis 1 grade Metavir developed clinical picture of essential mixed cryoglobulinemia II type with monoclonal IgM/kappa production. Cryoglobulinemia was presented with skin hemorrhagic vasculitis, proliferative vasculitis of small liver vessels, kidney involvement with III type membranoproliferative glomerulonephritis. Treatment with Dasabuvir;Оmbitasvir+Paritaprevir+Ritonavir without immunosuppressive medications or steroids resulted in persistent virologic response by 12 weeks after administration and also dramatic reduction of cryoglobulimenia from 27% to 8%, suppression of detectable IgM/kappa production, diminished skin vasculitis, restoration of glomerular filtration rate, proteinuria and decrease in erythrocyteuria. |
| first_indexed | 2024-03-12T04:46:05Z |
| format | Article |
| id | doaj.art-89f8e345d0b241d9bd17af5202bed793 |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2025-03-14T08:36:06Z |
| publishDate | 2016-07-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-89f8e345d0b241d9bd17af5202bed7932025-03-02T13:00:28ZrusJournal InfectologyЖурнал инфектологии2072-67322016-07-01824047474Antiviral therapy of chronic hepatitis C complicated by systemic cryoglobulinemic vasculitisN. V. Dunaeva0V. E. Karev1O. A. Vorobyeva2A. V. Mazing3S. V. Lapin4A. V. Smirnov5D. A. Gusev6Centers for AIDS and Other Infectious DiseasesScience Research Institute of Children’s InfectionsNational Center of Clinical Morphological DiagnosticsFirst Saint-Petersburg State Medical University named after I.P. PavlovFirst Saint-Petersburg State Medical University named after I.P. PavlovNovgorod State University named after Yaroslav-the-WiseCenters for AIDS and Other Infectious DiseasesLiterature analysis of published data on mechanisms of infection, disease progression and treatment of chronic hepatitis C, associated with systemic cryoglobulinemic vasculitis and kidney involvement is presented. A clinical case of effective treatment of cryoglobulinemic vasculitis associated with HCV infection is described. Female with HCV infection genotype 1b with liver fibrosis 1 grade Metavir developed clinical picture of essential mixed cryoglobulinemia II type with monoclonal IgM/kappa production. Cryoglobulinemia was presented with skin hemorrhagic vasculitis, proliferative vasculitis of small liver vessels, kidney involvement with III type membranoproliferative glomerulonephritis. Treatment with Dasabuvir;Оmbitasvir+Paritaprevir+Ritonavir without immunosuppressive medications or steroids resulted in persistent virologic response by 12 weeks after administration and also dramatic reduction of cryoglobulimenia from 27% to 8%, suppression of detectable IgM/kappa production, diminished skin vasculitis, restoration of glomerular filtration rate, proteinuria and decrease in erythrocyteuria.https://journal.niidi.ru/jofin/article/view/477chronic hepatitis ccryoglobulinemiacryoglobulinemic vasculitisglomerulonephritisparitaprenovirritonavirombitasvirdasabuvir3d therapy |
| spellingShingle | N. V. Dunaeva V. E. Karev O. A. Vorobyeva A. V. Mazing S. V. Lapin A. V. Smirnov D. A. Gusev Antiviral therapy of chronic hepatitis C complicated by systemic cryoglobulinemic vasculitis Журнал инфектологии chronic hepatitis c cryoglobulinemia cryoglobulinemic vasculitis glomerulonephritis paritaprenovir ritonavir ombitasvir dasabuvir 3d therapy |
| title | Antiviral therapy of chronic hepatitis C complicated by systemic cryoglobulinemic vasculitis |
| title_full | Antiviral therapy of chronic hepatitis C complicated by systemic cryoglobulinemic vasculitis |
| title_fullStr | Antiviral therapy of chronic hepatitis C complicated by systemic cryoglobulinemic vasculitis |
| title_full_unstemmed | Antiviral therapy of chronic hepatitis C complicated by systemic cryoglobulinemic vasculitis |
| title_short | Antiviral therapy of chronic hepatitis C complicated by systemic cryoglobulinemic vasculitis |
| title_sort | antiviral therapy of chronic hepatitis c complicated by systemic cryoglobulinemic vasculitis |
| topic | chronic hepatitis c cryoglobulinemia cryoglobulinemic vasculitis glomerulonephritis paritaprenovir ritonavir ombitasvir dasabuvir 3d therapy |
| url | https://journal.niidi.ru/jofin/article/view/477 |
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